Intrinsic Pathway for Apoptosis Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-109606
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Genes

55 proteins participating in the Intrinsic Pathway for Apoptosis pathway from the Reactome Pathways 2024 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APAF1 apoptotic peptidase activating factor 1
APIP APAF1 interacting protein
AVEN apoptosis, caspase activation inhibitor
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BMF Bcl2 modifying factor
C1QBP complement component 1, q subcomponent binding protein
CARD8 caspase recruitment domain family, member 8
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDKN2A cyclin-dependent kinase inhibitor 2A
CYCS cytochrome c, somatic
DIABLO diablo, IAP-binding mitochondrial protein
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
E2F1 E2F transcription factor 1
GSDMD gasdermin D
GSDME gasdermin E
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
NMT1 N-myristoyltransferase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
SEPTIN4 septin 4
SFN stratifin
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta