| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ipatasertib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.183624 |
| CDH13 | cadherin 13 | 0.12506 |
| SLC39A11 | solute carrier family 39, member 11 | 0.108996 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0923282 |
| EGFR | epidermal growth factor receptor | 0.0916737 |
| PODXL | podocalyxin-like | 0.082659 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0821494 |
| SMYD3 | SET and MYND domain containing 3 | 0.0734463 |
| COL5A1 | collagen, type V, alpha 1 | 0.0729902 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0721871 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0718583 |
| DST | dystonin | 0.0669692 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0660761 |
| FSTL1 | follistatin-like 1 | 0.0625449 |
| AHNAK | AHNAK nucleoprotein | 0.0610022 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0598157 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0590522 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0564476 |
| ASPH | aspartate beta-hydroxylase | 0.0546605 |
| PRELID2 | PRELI domain containing 2 | 0.0541678 |
| CD44 | CD44 molecule (Indian blood group) | 0.0530145 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.050517 |
| EFNA5 | ephrin-A5 | 0.0502441 |
| HDAC9 | histone deacetylase 9 | 0.0490402 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0477764 |
| FLNA | filamin A, alpha | 0.0458795 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.045455 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0448938 |
| CCND1 | cyclin D1 | 0.0432868 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0428193 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0425753 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0418863 |
| BPTF | bromodomain PHD finger transcription factor | 0.0414425 |
| TPM4 | tropomyosin 4 | 0.0414029 |
| NAV1 | neuron navigator 1 | 0.040506 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0403766 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0399942 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0397702 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0388045 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0381204 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0377013 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0376431 |
| RUNX1 | runt-related transcription factor 1 | 0.0369353 |
| NAV2 | neuron navigator 2 | 0.0369063 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0368957 |
| SQSTM1 | sequestosome 1 | 0.0362138 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0360087 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0352203 |
| RPL37A | ribosomal protein L37a | 0.0350569 |
| PCDH7 | protocadherin 7 | 0.0347169 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0343072 |
| CDK13 | cyclin-dependent kinase 13 | 0.0330567 |
| COL3A1 | collagen, type III, alpha 1 | 0.033044 |
| ACTG1 | actin gamma 1 | 0.0326256 |
| FNIP1 | folliculin interacting protein 1 | 0.0323942 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0321921 |
| CUX1 | cut-like homeobox 1 | 0.0321647 |
| GSE1 | Gse1 coiled-coil protein | 0.0320189 |
| TENM3 | teneurin transmembrane protein 3 | 0.0309454 |
| CSTB | cystatin B (stefin B) | 0.0303264 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0302139 |
| VCL | vinculin | 0.0294116 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0291977 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0288806 |
| ANXA5 | annexin A5 | 0.0286756 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0285311 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0285162 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0281828 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0279223 |
| CAVIN1 | caveolae associated protein 1 | 0.0274433 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0271631 |
| TBCA | tubulin folding cofactor A | 0.0268135 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0266804 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0266004 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 0.0264916 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0264764 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0263482 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0263448 |
| RPS3 | ribosomal protein S3 | 0.0263289 |
| ENO1 | enolase 1, (alpha) | 0.0261583 |
| LMNA | lamin A/C | 0.0259956 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0258288 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0257536 |
| CDK6 | cyclin-dependent kinase 6 | 0.0256648 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.025637 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0255446 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0254634 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0254619 |
| RASAL2 | RAS protein activator like 2 | 0.0251507 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0251037 |
| S100A10 | S100 calcium binding protein A10 | 0.0250359 |
| SEPTIN9 | septin 9 | 0.0249922 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.024655 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0246534 |
| RPL26 | ribosomal protein L26 | 0.0245773 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0245692 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0245191 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0244465 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0242475 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0241817 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.183943 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.178908 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.162839 |
| TMSB10 | thymosin beta 10 | -0.1227 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.084369 |
| FBN1 | fibrillin 1 | -0.0756518 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0701917 |
| MT2A | metallothionein 2A | -0.069697 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.066883 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0620566 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0601193 |
| PLAT | plasminogen activator, tissue | -0.0572635 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0502031 |
| MX2 | MX dynamin-like GTPase 2 | -0.0496726 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0484639 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0444206 |
| COL1A2 | collagen, type I, alpha 2 | -0.0427723 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0418806 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0411934 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0408423 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0396404 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0390445 |
| NDRG1 | N-myc downstream regulated 1 | -0.0388004 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0376995 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0372868 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0367655 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0361855 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0358961 |
| UBC | ubiquitin C | -0.0358914 |
| LOX | lysyl oxidase | -0.0349997 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0345283 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0327858 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0325643 |
| MT1X | metallothionein 1X | -0.0315155 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0313676 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.031172 |
| FNDC3B | fibronectin type III domain containing 3B | -0.030434 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0302266 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0295176 |
| TAGLN2 | transgelin 2 | -0.0292819 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0280335 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0279365 |
| ADM | adrenomedullin | -0.0276583 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0267889 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0263466 |
| STC1 | stanniocalcin 1 | -0.0261478 |
| B2M | beta-2-microglobulin | -0.0251535 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0248364 |
| MYADM | myeloid-associated differentiation marker | -0.0243191 |
| WTAP | Wilms tumor 1 associated protein | -0.0240245 |
| IER3 | immediate early response 3 | -0.0236639 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0235363 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0225287 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.021779 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0217127 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0216599 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | -0.0213114 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0212531 |
| PTMA | prothymosin, alpha | -0.0211224 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0209955 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0205188 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0203053 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0198395 |
| JUN | jun proto-oncogene | -0.0198313 |
| FLNB | filamin B, beta | -0.0196104 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0196036 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.019351 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0192892 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0191302 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0189105 |
| OPTN | optineurin | -0.0185756 |
| TMOD1 | tropomodulin 1 | -0.018299 |
| INSIG1 | insulin induced gene 1 | -0.0179415 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0177144 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0176461 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0173757 |
| RIGI | RNA sensor RIG-I | -0.0173478 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0173134 |
| FN1 | fibronectin 1 | -0.0172847 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0172845 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0170989 |
| SDC4 | syndecan 4 | -0.0169946 |
| CLU | clusterin | -0.0169595 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0169007 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.0168455 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0168013 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0167757 |
| HLA-E | major histocompatibility complex, class I, E | -0.0163323 |
| FOSL1 | FOS-like antigen 1 | -0.0162658 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0158592 |
| IRF1 | interferon regulatory factor 1 | -0.0157777 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0157726 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.015619 |
| SETD5 | SET domain containing 5 | -0.0154454 |
| FAM162A | family with sequence similarity 162, member A | -0.0152079 |
| VEGFA | vascular endothelial growth factor A | -0.0151738 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0150437 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0147931 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.0146837 |
| EGR1 | early growth response 1 | -0.01463 |
