| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ipatasertib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.213704 |
| HMGA2 | high mobility group AT-hook 2 | 0.13119 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.100286 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0811344 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0794873 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0792489 |
| RPS12 | ribosomal protein S12 | 0.0771187 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0741685 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0732261 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0706568 |
| JMJD1C | jumonji domain containing 1C | 0.0696391 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0587566 |
| YAP1 | Yes-associated protein 1 | 0.0557872 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0557301 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0555247 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0527775 |
| NLGN1 | neuroligin 1 | 0.0524561 |
| HDAC9 | histone deacetylase 9 | 0.0522562 |
| VMP1 | vacuole membrane protein 1 | 0.0519298 |
| TENM3 | teneurin transmembrane protein 3 | 0.0506466 |
| EHBP1 | EH domain binding protein 1 | 0.0504217 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0488565 |
| RPS8 | ribosomal protein S8 | 0.0479888 |
| DTNA | dystrobrevin, alpha | 0.0479756 |
| NEBL | nebulette | 0.0477664 |
| VIM | vimentin | 0.0465859 |
| PDGFC | platelet derived growth factor C | 0.045515 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0451927 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0443237 |
| RPS29 | ribosomal protein S29 | 0.0434163 |
| SERTAD2 | SERTA domain containing 2 | 0.0429063 |
| EXOC6B | exocyst complex component 6B | 0.0428862 |
| PCDH9 | protocadherin 9 | 0.0419689 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0415489 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0412717 |
| PCDH7 | protocadherin 7 | 0.0411179 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0406078 |
| PCBP2 | poly(rC) binding protein 2 | 0.0404367 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0403399 |
| RPS3 | ribosomal protein S3 | 0.0402941 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0402393 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0401632 |
| MED13L | mediator complex subunit 13-like | 0.0400096 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0398053 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0392427 |
| MMP12 | matrix metallopeptidase 12 | 0.0391159 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0388883 |
| INTS6 | integrator complex subunit 6 | 0.0383678 |
| BPTF | bromodomain PHD finger transcription factor | 0.0378441 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0372039 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0370747 |
| RPL37A | ribosomal protein L37a | 0.0365639 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0364936 |
| RPL31 | ribosomal protein L31 | 0.0363232 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0359812 |
| USP34 | ubiquitin specific peptidase 34 | 0.0349086 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0346881 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0344309 |
| MYPN | myopalladin | 0.0339309 |
| NRXN3 | neurexin 3 | 0.0333535 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0331193 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0329301 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.032703 |
| DENND5A | DENN/MADD domain containing 5A | 0.0325185 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0321405 |
| RAB10 | RAB10, member RAS oncogene family | 0.0320272 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0319074 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0311139 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0309811 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0307418 |
| CMIP | c-Maf inducing protein | 0.0301094 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0298184 |
| RPS23 | ribosomal protein S23 | 0.029649 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0293319 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0293274 |
| BCHE | butyrylcholinesterase | 0.029142 |
| NFIB | nuclear factor I/B | 0.0291008 |
| ZNF638 | zinc finger protein 638 | 0.0290509 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0290339 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0285381 |
| EPHA5 | EPH receptor A5 | 0.0283888 |
| RPL5 | ribosomal protein L5 | 0.0281278 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0280082 |
| XPOT | exportin, tRNA | 0.0279574 |
| EGFR | epidermal growth factor receptor | 0.0274099 |
| FBXO11 | F-box protein 11 | 0.0272631 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0270097 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0268817 |
| WWOX | WW domain containing oxidoreductase | 0.0268164 |
| RTN3 | reticulon 3 | 0.0264968 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0264539 |
| BRD2 | bromodomain containing 2 | 0.0263421 |
| RPS13 | ribosomal protein S13 | 0.0262483 |
| RPS2 | ribosomal protein S2 | 0.0262161 |
| PRKCE | protein kinase C, epsilon | 0.0262157 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0262145 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0259644 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0258486 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0256167 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0255646 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.12181 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.12089 |
| MYL12B | myosin, light chain 12B, regulatory | -0.104233 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0926794 |
| PTMA | prothymosin, alpha | -0.0853869 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0839467 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0715098 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0701481 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0656557 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0656191 |
| MKI67 | marker of proliferation Ki-67 | -0.0649428 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.062641 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.061262 |
| H1-0 | H1.0 linker histone | -0.0579784 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0531647 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0529014 |
| AHNAK | AHNAK nucleoprotein | -0.0523403 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0521058 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.050035 |
| CENPF | centromere protein F, 350/400kDa | -0.0477519 |
| AREG | amphiregulin | -0.0450207 |
| RPL35A | ribosomal protein L35a | -0.0445688 |
| YBX3 | Y box binding protein 3 | -0.0444189 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0436978 |
| TMEM123 | transmembrane protein 123 | -0.0435191 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0425018 |
| LMO7 | LIM domain 7 | -0.0421471 |
| YBX1 | Y box binding protein 1 | -0.0417334 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0415588 |
| CLDN1 | claudin 1 | -0.0396574 |
| ECT2 | epithelial cell transforming 2 | -0.0386138 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0379687 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0379022 |
| RRM2 | ribonucleotide reductase M2 | -0.0378933 |
| ACTG1 | actin gamma 1 | -0.0377835 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0377406 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0376904 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.036937 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0367 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0363813 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0362123 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0359523 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0359434 |
| HMGB1 | high mobility group box 1 | -0.0357637 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.034874 |
| RPS24 | ribosomal protein S24 | -0.0344563 |
| TUBB | tubulin, beta class I | -0.0338827 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0314164 |
| CANX | calnexin | -0.0311097 |
| RPL12 | ribosomal protein L12 | -0.0309061 |
| TPX2 | TPX2, microtubule-associated | -0.0303082 |
| KIF5B | kinesin family member 5B | -0.0301314 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0295429 |
| ZNF217 | zinc finger protein 217 | -0.0287784 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0283173 |
| MTAP | methylthioadenosine phosphorylase | -0.027676 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0276676 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0274885 |
| CCDC47 | coiled-coil domain containing 47 | -0.027266 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0272019 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0262426 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0260894 |
| RPS19 | ribosomal protein S19 | -0.0258996 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0256178 |
| TUBA1B | tubulin, alpha 1b | -0.0253846 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0252461 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0251351 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0244068 |
| HMGB2 | high mobility group box 2 | -0.0243976 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0243805 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0243611 |
| GCG | glucagon | -0.0242412 |
| CLTC | clathrin, heavy chain (Hc) | -0.0240349 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0238894 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0238063 |
| RPL34 | ribosomal protein L34 | -0.0237168 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0235941 |
| DIAPH3 | diaphanous-related formin 3 | -0.023104 |
| SGO2 | shugoshin 2 | -0.0225606 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0224929 |
| DEK | DEK proto-oncogene | -0.022469 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0221906 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0219877 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0218713 |
| IL6ST | interleukin 6 signal transducer | -0.0218686 |
| FUS | FUS RNA binding protein | -0.021524 |
| NDC80 | NDC80 kinetochore complex component | -0.021516 |
| PGK1 | phosphoglycerate kinase 1 | -0.0213877 |
| TPI1 | triosephosphate isomerase 1 | -0.0213404 |
| RPL23 | ribosomal protein L23 | -0.0213195 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0210572 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0210059 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0208505 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0207514 |
| RPL11 | ribosomal protein L11 | -0.0207198 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0206798 |
| STMN1 | stathmin 1 | -0.0206063 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0203798 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0202389 |
| KIF18B | kinesin family member 18B | -0.0201171 |
