| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ipatasertib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.245697 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.159764 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.123071 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.103706 |
| TRERF1 | transcriptional regulating factor 1 | 0.0984622 |
| MAP7 | microtubule-associated protein 7 | 0.0949197 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0942768 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.09318 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0929083 |
| RUNX1 | runt-related transcription factor 1 | 0.0860264 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0823849 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0811686 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0769735 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0740308 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0720872 |
| NCKAP5 | NCK-associated protein 5 | 0.070607 |
| SMAD3 | SMAD family member 3 | 0.0703889 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0697194 |
| ATXN1 | ataxin 1 | 0.06969 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0662693 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.061427 |
| SERINC5 | serine incorporator 5 | 0.0599564 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0579351 |
| RBM47 | RNA binding motif protein 47 | 0.0571488 |
| SMYD3 | SET and MYND domain containing 3 | 0.056299 |
| VCL | vinculin | 0.0543411 |
| MYO1E | myosin IE | 0.054263 |
| YAP1 | Yes-associated protein 1 | 0.0542376 |
| PERP | PERP, TP53 apoptosis effector | 0.0541809 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0536368 |
| RPS6 | ribosomal protein S6 | 0.0533074 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0527276 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0520829 |
| AHI1 | Abelson helper integration site 1 | 0.0498723 |
| BCL2L1 | BCL2-like 1 | 0.0497752 |
| SEPTIN9 | septin 9 | 0.0493911 |
| PHF3 | PHD finger protein 3 | 0.0493433 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0481371 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0472883 |
| ASPH | aspartate beta-hydroxylase | 0.0470138 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0469568 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0461613 |
| ATP11A | ATPase, class VI, type 11A | 0.0453184 |
| FTL | ferritin, light polypeptide | 0.0450736 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0442509 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0439385 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0437812 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0432901 |
| BPTF | bromodomain PHD finger transcription factor | 0.0423922 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0423549 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0422895 |
| DSTN | destrin (actin depolymerizing factor) | 0.0422872 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0422587 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0422161 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0422128 |
| NF1 | neurofibromin 1 | 0.0419337 |
| TJP1 | tight junction protein 1 | 0.0416568 |
| EFNB2 | ephrin-B2 | 0.0416038 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0408059 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0407739 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0402966 |
| SPATA13 | spermatogenesis associated 13 | 0.0402664 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.039219 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0386374 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0384709 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0381203 |
| TOX3 | TOX high mobility group box family member 3 | 0.0380969 |
| RPS8 | ribosomal protein S8 | 0.0374524 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.037318 |
| RAB10 | RAB10, member RAS oncogene family | 0.0364269 |
| RPS3 | ribosomal protein S3 | 0.0351971 |
| DST | dystonin | 0.034837 |
| SFTPA2 | surfactant protein A2 | 0.0348273 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0347712 |
| CCND3 | cyclin D3 | 0.0347387 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0346919 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0345395 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0342302 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0341788 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | 0.0341409 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0340747 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0339554 |
| TXNRD1 | thioredoxin reductase 1 | 0.0339516 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0338557 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0338122 |
| CTBP2 | C-terminal binding protein 2 | 0.0335601 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0330657 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0330408 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0329351 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0325308 |
| STK24 | serine/threonine kinase 24 | 0.032441 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0322489 |
| SNX29 | sorting nexin 29 | 0.0318739 |
| RPL9 | ribosomal protein L9 | 0.0315927 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0315098 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0313701 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0312238 |
| ENO1 | enolase 1, (alpha) | 0.0308958 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0306854 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0305678 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.119453 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.10592 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0922492 |
| RIGI | RNA sensor RIG-I | -0.0731477 |
| MX1 | MX dynamin-like GTPase 1 | -0.069785 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0696245 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0668229 |
| SQSTM1 | sequestosome 1 | -0.0613717 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0601923 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0599465 |
| TXNIP | thioredoxin interacting protein | -0.0589692 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0583254 |
| MX2 | MX dynamin-like GTPase 2 | -0.0562015 |
| RNF213 | ring finger protein 213 | -0.0535545 |
| H1-0 | H1.0 linker histone | -0.0531219 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0524085 |
| EGR1 | early growth response 1 | -0.0523188 |
| FNDC3B | fibronectin type III domain containing 3B | -0.047828 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0451158 |
| LCN2 | lipocalin 2 | -0.0450844 |
| EZR | ezrin | -0.0438659 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0434367 |
| CCNL1 | cyclin L1 | -0.043327 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.043193 |
| PLSCR1 | phospholipid scramblase 1 | -0.0424423 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0405973 |
| NDRG1 | N-myc downstream regulated 1 | -0.0400536 |
| APOL1 | apolipoprotein L, 1 | -0.0391409 |
| PLSCR2 | phospholipid scramblase 2 | -0.038644 |
| SP100 | SP100 nuclear antigen | -0.0384458 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0377946 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0355696 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0353285 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.03532 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0351866 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0351175 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0342529 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.032819 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0291723 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0284036 |
| XAF1 | XIAP associated factor 1 | -0.0281956 |
| ATP10B | ATPase, class V, type 10B | -0.0276402 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0268443 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0265494 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0262359 |
| SDC4 | syndecan 4 | -0.026087 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0253352 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0252805 |
| LYZ | lysozyme | -0.0247927 |
| GRK3 | G protein-coupled receptor kinase 3 | -0.0245358 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0245098 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0245061 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0242459 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0233102 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0232261 |
| IRF1 | interferon regulatory factor 1 | -0.0222331 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0218094 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0214933 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0213512 |
| JUN | jun proto-oncogene | -0.0213475 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0208668 |
| STK39 | serine threonine kinase 39 | -0.0207916 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0205285 |
| SDCBP | syndecan binding protein (syntenin) | -0.0198528 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0192966 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0190269 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0188646 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0188137 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0188103 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0182355 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0180016 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0179392 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0177044 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0175685 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0174189 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0173732 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0173522 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0172797 |
| KYNU | kynureninase | -0.017248 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0172156 |
| DYNC2I1 | dynein 2 intermediate chain 1 | -0.0172114 |
| KIF16B | kinesin family member 16B | -0.0172102 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0171349 |
| ARRDC3 | arrestin domain containing 3 | -0.0171162 |
| LAP3 | leucine aminopeptidase 3 | -0.0169238 |
| OXSR1 | oxidative stress responsive 1 | -0.0168091 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | -0.0166832 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0166507 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0164501 |
| NPSR1 | neuropeptide S receptor 1 | -0.0164407 |
| FBXO39 | F-box protein 39 | -0.0163771 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0163483 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0162471 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0162029 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0159426 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0156333 |
| TRIM22 | tripartite motif containing 22 | -0.0156154 |
| ARF4 | ADP-ribosylation factor 4 | -0.0155994 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0155711 |
| PMP22 | peripheral myelin protein 22 | -0.0155155 |
