Ipatasertib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ipatasertib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.176862
NDRG1 N-myc downstream regulated 1 0.167503
CDH13 cadherin 13 0.120866
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.109309
EXT1 exostosin glycosyltransferase 1 0.102244
ASPH aspartate beta-hydroxylase 0.0964345
VEGFA vascular endothelial growth factor A 0.0917829
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0902861
PSD3 pleckstrin and Sec7 domain containing 3 0.0749262
VIM vimentin 0.0717273
MBNL1 muscleblind-like splicing regulator 1 0.0681543
TGFBI transforming growth factor, beta-induced, 68kDa 0.0658611
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0633671
EGFR epidermal growth factor receptor 0.0599234
RPS8 ribosomal protein S8 0.0565914
COL5A1 collagen, type V, alpha 1 0.0548048
ZSWIM6 zinc finger, SWIM-type containing 6 0.0496284
LPP LIM domain containing preferred translocation partner in lipoma 0.0485889
ATXN1 ataxin 1 0.0460223
CD44 CD44 molecule (Indian blood group) 0.0452286
ZBTB20 zinc finger and BTB domain containing 20 0.0445195
RPL5 ribosomal protein L5 0.0443418
FNIP1 folliculin interacting protein 1 0.0430436
RPS6 ribosomal protein S6 0.0427173
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0421493
DOCK5 dedicator of cytokinesis 5 0.0389494
AKAP9 A kinase (PRKA) anchor protein 9 0.0386375
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0379506
DPYSL2 dihydropyrimidinase-like 2 0.0378385
TTC3 tetratricopeptide repeat domain 3 0.0374112
WWTR1 WW domain containing transcription regulator 1 0.0372992
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.037081
RPS12 ribosomal protein S12 0.0370252
ENO1 enolase 1, (alpha) 0.0369187
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0367439
IGFBP7 insulin-like growth factor binding protein 7 0.0365537
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0362797
BACE2 beta-site APP-cleaving enzyme 2 0.0347492
SMYD3 SET and MYND domain containing 3 0.0341747
RPS3 ribosomal protein S3 0.0336247
MTDH metadherin 0.03291
RUNX1 runt-related transcription factor 1 0.0313498
CDK13 cyclin-dependent kinase 13 0.0311311
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0304231
ANKRD12 ankyrin repeat domain 12 0.0304199
ANXA5 annexin A5 0.0303982
BPTF bromodomain PHD finger transcription factor 0.0302013
CUX1 cut-like homeobox 1 0.0299257
NAV1 neuron navigator 1 0.0296455
NAV2 neuron navigator 2 0.0292562
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0289922
CMIP c-Maf inducing protein 0.0288864
PTPRG protein tyrosine phosphatase, receptor type, G 0.028805
RPL37A ribosomal protein L37a 0.0286685
GOLGB1 golgin B1 0.0286583
RAB7A RAB7A, member RAS oncogene family 0.0281739
LTBP1 latent transforming growth factor beta binding protein 1 0.0280131
ANKRD28 ankyrin repeat domain 28 0.0275678
ITGA11 integrin, alpha 11 0.0270858
PRKCA protein kinase C, alpha 0.0267677
PRELID2 PRELI domain containing 2 0.0267488
ANKH ANKH inorganic pyrophosphate transport regulator 0.0267431
RPL9 ribosomal protein L9 0.0266593
GPC6 glypican 6 0.0263251
CSNK1A1 casein kinase 1, alpha 1 0.026123
ANKRD11 ankyrin repeat domain 11 0.0258824
RACK1 receptor for activated C kinase 1 0.025752
AGO3 argonaute RISC catalytic component 3 0.025644
VCL vinculin 0.0252794
PDE4D phosphodiesterase 4D, cAMP-specific 0.0251804
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0251385
PDLIM5 PDZ and LIM domain 5 0.0249672
ANKRD17 ankyrin repeat domain 17 0.0246369
FBXL13 F-box and leucine-rich repeat protein 13 0.024446
ACTG1 actin gamma 1 0.0243831
RPL31 ribosomal protein L31 0.0242634
CCND1 cyclin D1 0.0240304
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0239011
RPS25 ribosomal protein S25 0.023758
MACF1 microtubule-actin crosslinking factor 1 0.023753
SVIL supervillin 0.023702
JARID2 jumonji, AT rich interactive domain 2 0.0236386
PTPRM protein tyrosine phosphatase, receptor type, M 0.0235966
SPDYA speedy/RINGO cell cycle regulator family member A 0.0235352
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0228934
IARS1 isoleucyl-tRNA synthetase 1 0.0228648
HM13 histocompatibility (minor) 13 0.0226469
PICALM phosphatidylinositol binding clathrin assembly protein 0.0226153
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.02253
RAB2A RAB2A, member RAS oncogene family 0.0222282
FBXL7 F-box and leucine-rich repeat protein 7 0.0220076
CHD9 chromodomain helicase DNA binding protein 9 0.0217655
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0217251
RPL7 ribosomal protein L7 0.0213169
RPS2 ribosomal protein S2 0.0212388
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0210744
CTSB cathepsin B 0.0209963
BBS9 Bardet-Biedl syndrome 9 0.0208204
TPT1 tumor protein, translationally-controlled 1 0.020651
ZNF644 zinc finger protein 644 0.0205016

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.307728
FN1 fibronectin 1 -0.237756
CXCL8 chemokine (C-X-C motif) ligand 8 -0.175504
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.132146
IGFBP3 insulin-like growth factor binding protein 3 -0.114447
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108192
IER3 immediate early response 3 -0.085252
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0808866
NAMPT nicotinamide phosphoribosyltransferase -0.0732176
TMSB10 thymosin beta 10 -0.0607179
CADM1 cell adhesion molecule 1 -0.057052
CANX calnexin -0.0543711
STC1 stanniocalcin 1 -0.0540989
INHBA inhibin, beta A -0.0531818
ELL2 elongation factor, RNA polymerase II, 2 -0.0490163
PTMA prothymosin, alpha -0.0480295
COL1A1 collagen, type I, alpha 1 -0.0459822
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0452687
SOD2 superoxide dismutase 2, mitochondrial -0.0433013
MT1X metallothionein 1X -0.0426922
ATP13A3 ATPase type 13A3 -0.0426208
TM4SF1 transmembrane 4 L six family member 1 -0.041161
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0367251
TMSB4X thymosin beta 4, X-linked -0.0363476
FTH1 ferritin, heavy polypeptide 1 -0.0328081
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0327785
H1-0 H1.0 linker histone -0.0319121
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0312445
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0308633
LMAN1 lectin, mannose-binding, 1 -0.029868
USP3 ubiquitin specific peptidase 3 -0.0298035
TRIO trio Rho guanine nucleotide exchange factor -0.0297257
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0296866
MAP1B microtubule-associated protein 1B -0.0290825
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0289575
F3 coagulation factor III (thromboplastin, tissue factor) -0.0282652
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0279567
RAD21 RAD21 homolog (S. pombe) -0.027849
TNIP1 TNFAIP3 interacting protein 1 -0.0259481
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0244315
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0238785
ICAM1 intercellular adhesion molecule 1 -0.0234988
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0231302
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0230389
BHLHE40 basic helix-loop-helix family, member e40 -0.0229134
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0223126
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0221695
QKI QKI, KH domain containing, RNA binding -0.0218523
KDM3A lysine (K)-specific demethylase 3A -0.0218503
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0215833
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.021506
SPAG9 sperm associated antigen 9 -0.0210889
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0210866
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0207897
IL6 interleukin 6 -0.0201678
TFG TRK-fused gene -0.0198106
RLF rearranged L-myc fusion -0.0197183
PGK1 phosphoglycerate kinase 1 -0.019314
DPYD dihydropyrimidine dehydrogenase -0.0191357
HMGB2 high mobility group box 2 -0.0189475
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0189396
YBX1 Y box binding protein 1 -0.0187252
HILPDA hypoxia inducible lipid droplet-associated -0.0183395
RHEB Ras homolog enriched in brain -0.0177232
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0174402
MARCHF6 membrane associated ring-CH-type finger 6 -0.0169467
ZFAND3 zinc finger, AN1-type domain 3 -0.0168482
PDIA4 protein disulfide isomerase family A, member 4 -0.0167181
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0166438
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0166108
BZW1 basic leucine zipper and W2 domains 1 -0.016583
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0163713
SAMD9 sterile alpha motif domain containing 9 -0.016154
PDIA3 protein disulfide isomerase family A, member 3 -0.0161509
RIGI RNA sensor RIG-I -0.0160909
ANLN anillin, actin binding protein -0.0159471
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0157543
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0157072
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0156915
HAS2 hyaluronan synthase 2 -0.015562
HDLBP high density lipoprotein binding protein -0.0155541
NPEPPS aminopeptidase puromycin sensitive -0.0155444
SQLE squalene epoxidase -0.0151787
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0151121
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0149834
TMEM263 transmembrane protein 263 -0.0148705
POSTN periostin, osteoblast specific factor -0.0148692
AHNAK AHNAK nucleoprotein -0.0147448
IER3IP1 immediate early response 3 interacting protein 1 -0.014651
WTAP Wilms tumor 1 associated protein -0.0146335
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0146301
FAM162A family with sequence similarity 162, member A -0.0145505
SEPTIN7 septin 7 -0.0144167
SMAD3 SMAD family member 3 -0.0143656
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0142209
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0142059
CCNL1 cyclin L1 -0.0141854
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0141136
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0140546
ADAM17 ADAM metallopeptidase domain 17 -0.0137365