| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ipatasertib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.526505 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.141782 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0747508 |
| GPC6 | glypican 6 | 0.0672942 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0641078 |
| KIF1B | kinesin family member 1B | 0.0429894 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0389821 |
| MED13L | mediator complex subunit 13-like | 0.0383993 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0341483 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.03321 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0322633 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0308035 |
| GPHN | gephyrin | 0.0295155 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0285204 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.028464 |
| PEG10 | paternally expressed 10 | 0.0281951 |
| CNKSR3 | CNKSR family member 3 | 0.0273652 |
| PARD3 | par-3 family cell polarity regulator | 0.024037 |
| ANXA5 | annexin A5 | 0.0232025 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0231476 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0225873 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0213759 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0212715 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0208882 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0204147 |
| RPL5 | ribosomal protein L5 | 0.0199029 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0193649 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0193422 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0183998 |
| LMO7 | LIM domain 7 | 0.0181139 |
| TCF12 | transcription factor 12 | 0.0180333 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0176437 |
| RTN4 | reticulon 4 | 0.0176168 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0173486 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0171434 |
| NHSL1 | NHS-like 1 | 0.0167365 |
| KLF12 | Kruppel-like factor 12 | 0.0165776 |
| SVIL | supervillin | 0.016091 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0160515 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0159506 |
| FAT1 | FAT atypical cadherin 1 | 0.0158151 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0158024 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0157143 |
| MCU | mitochondrial calcium uniporter | 0.0156426 |
| ITGA6 | integrin, alpha 6 | 0.0154259 |
| CDC14A | cell division cycle 14A | 0.0153713 |
| DSTN | destrin (actin depolymerizing factor) | 0.0153062 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0152929 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0146612 |
| LUZP1 | leucine zipper protein 1 | 0.0145931 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0145104 |
| RASAL2 | RAS protein activator like 2 | 0.0143603 |
| NCKAP1 | NCK-associated protein 1 | 0.0142636 |
| FLNB | filamin B, beta | 0.0141777 |
| AGPS | alkylglycerone phosphate synthase | 0.0141066 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.014045 |
| SMYD3 | SET and MYND domain containing 3 | 0.0139472 |
| TF | transferrin | 0.0137067 |
| PRKCA | protein kinase C, alpha | 0.0134963 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.0134834 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0133012 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0132788 |
| PDGFC | platelet derived growth factor C | 0.0131106 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0130941 |
| FNBP1L | formin binding protein 1-like | 0.0130533 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0130347 |
| CDYL | chromodomain protein, Y-like | 0.0129916 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0129904 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0129719 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0129435 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.01291 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0127919 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0125621 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0125464 |
| AHR | aryl hydrocarbon receptor | 0.012505 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0124107 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 0.0123933 |
| SSH2 | slingshot protein phosphatase 2 | 0.01238 |
| TSPAN14 | tetraspanin 14 | 0.0122756 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0122172 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0121898 |
| FAM117B | family with sequence similarity 117, member B | 0.0121113 |
| NFIA | nuclear factor I/A | 0.0119881 |
| RNF43 | ring finger protein 43 | 0.0118596 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0118325 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0116784 |
| COBL | cordon-bleu WH2 repeat protein | 0.0115697 |
| ABI1 | abl-interactor 1 | 0.0115568 |
| POTEF | POTE ankyrin domain family, member F | 0.011505 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.0114555 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.0114355 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.011434 |
| SMAD5 | SMAD family member 5 | 0.0114321 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.011296 |
| TMEM131 | transmembrane protein 131 | 0.0112142 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0111629 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0110739 |
| CCNY | cyclin Y | 0.0110161 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0109602 |
| RBM6 | RNA binding motif protein 6 | 0.01091 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.199792 |
| FN1 | fibronectin 1 | -0.183342 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.132853 |
| FNDC3B | fibronectin type III domain containing 3B | -0.122707 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.11262 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.104688 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.104527 |
| ENO1 | enolase 1, (alpha) | -0.104217 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.101059 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0971872 |
| PEG3 | paternally expressed 3 | -0.0892188 |
| EHBP1 | EH domain binding protein 1 | -0.0890103 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0874158 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0841888 |
| APOB | apolipoprotein B | -0.082713 |
| ATXN1 | ataxin 1 | -0.0801345 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0795071 |
| DSPP | dentin sialophosphoprotein | -0.0763699 |
| PLIN2 | perilipin 2 | -0.0758622 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0729587 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0686767 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0674966 |
| CP | ceruloplasmin (ferroxidase) | -0.066919 |
| ASPH | aspartate beta-hydroxylase | -0.0664517 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0644564 |
| VCL | vinculin | -0.0626042 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0616004 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0596472 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0589549 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0566273 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0549303 |
| H1-0 | H1.0 linker histone | -0.0547165 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0546121 |
| CANX | calnexin | -0.0544229 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0525648 |
| APOA2 | apolipoprotein A-II | -0.051176 |
| RNF213 | ring finger protein 213 | -0.0505388 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0495468 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.048861 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0471876 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0445943 |
| MT2A | metallothionein 2A | -0.0436572 |
| GK | glycerol kinase | -0.0414624 |
| TPM4 | tropomyosin 4 | -0.0392908 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0390115 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0389105 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0384815 |
| SDC4 | syndecan 4 | -0.037183 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0367597 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.036033 |
| PGK1 | phosphoglycerate kinase 1 | -0.0358495 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0351596 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0350708 |
| TMSB10 | thymosin beta 10 | -0.0350184 |
| RNASET2 | ribonuclease T2 | -0.0343388 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.034019 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0337949 |
| RUNX1 | runt-related transcription factor 1 | -0.0337549 |
| RPS24 | ribosomal protein S24 | -0.0336348 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0334596 |
| SQSTM1 | sequestosome 1 | -0.0333903 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0326389 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0313873 |
| PHF3 | PHD finger protein 3 | -0.031274 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0311514 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0311051 |
| LDHA | lactate dehydrogenase A | -0.0297685 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0294609 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0291667 |
| GNAS | GNAS complex locus | -0.0283823 |
| RPS6 | ribosomal protein S6 | -0.0283157 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0281476 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0280803 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.027967 |
| ITGAV | integrin, alpha V | -0.0278354 |
| RPS19 | ribosomal protein S19 | -0.0276117 |
| MCL1 | myeloid cell leukemia 1 | -0.027577 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.027566 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.027394 |
| C3 | complement component 3 | -0.0273596 |
| RIGI | RNA sensor RIG-I | -0.0272123 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0271758 |
| FILIP1L | filamin A interacting protein 1-like | -0.0268273 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0260973 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0260734 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.025538 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0255069 |
| DST | dystonin | -0.0252459 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0250934 |
| HM13 | histocompatibility (minor) 13 | -0.0247217 |
| MAP1B | microtubule-associated protein 1B | -0.0245874 |
| PLXDC2 | plexin domain containing 2 | -0.024579 |
| OSMR | oncostatin M receptor | -0.0245677 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0244372 |
| KRT23 | keratin 23, type I | -0.0243403 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0241685 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0239547 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0238597 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0238059 |
| CLTC | clathrin, heavy chain (Hc) | -0.0237546 |
