Ipatasertib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MBNL1 muscleblind-like splicing regulator 1 0.150282
NDRG1 N-myc downstream regulated 1 0.114196
LMO7 LIM domain 7 0.097994
RAI14 retinoic acid induced 14 0.0971226
RPS8 ribosomal protein S8 0.0858881
PDE4D phosphodiesterase 4D, cAMP-specific 0.0858165
MTSS1 metastasis suppressor 1 0.0851351
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0737359
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0713022
PDLIM5 PDZ and LIM domain 5 0.0662245
CD44 CD44 molecule (Indian blood group) 0.065292
AOPEP aminopeptidase O (putative) 0.0638186
DSCAM Down syndrome cell adhesion molecule 0.0625031
RPL5 ribosomal protein L5 0.0621491
RPL37 ribosomal protein L37 0.0618729
MBNL2 muscleblind-like splicing regulator 2 0.0617009
AKAP9 A kinase (PRKA) anchor protein 9 0.0604464
FOXP1 forkhead box P1 0.060375
KLF5 Kruppel-like factor 5 (intestinal) 0.0601105
FNIP1 folliculin interacting protein 1 0.0567013
RPS12 ribosomal protein S12 0.0555679
ASPH aspartate beta-hydroxylase 0.0550227
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.053473
CNTNAP3 contactin associated protein-like 3 0.0534395
MT2A metallothionein 2A 0.0518651
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0516184
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0514815
RPS3 ribosomal protein S3 0.0508914
NRIP1 nuclear receptor interacting protein 1 0.0493874
ITCH itchy E3 ubiquitin protein ligase 0.046574
RPS6 ribosomal protein S6 0.0449067
SMAD3 SMAD family member 3 0.0444134
RABGAP1L RAB GTPase activating protein 1-like 0.0444053
LIFR leukemia inhibitory factor receptor alpha 0.0439332
CDK13 cyclin-dependent kinase 13 0.0435668
TPT1 tumor protein, translationally-controlled 1 0.0435586
INTS6 integrator complex subunit 6 0.043263
DOK5 docking protein 5 0.042557
EFNA5 ephrin-A5 0.0422689
MRPS6 mitochondrial ribosomal protein S6 0.0415514
FNDC3B fibronectin type III domain containing 3B 0.0404227
JMJD1C jumonji domain containing 1C 0.0402072
LYST lysosomal trafficking regulator 0.0395391
MYOF myoferlin 0.0391888
EXT1 exostosin glycosyltransferase 1 0.0384888
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0381172
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0377655
OSBPL6 oxysterol binding protein-like 6 0.0376306
ATXN1 ataxin 1 0.037501
OSMR oncostatin M receptor 0.0373225
ANKRD17 ankyrin repeat domain 17 0.0370631
PTK2 protein tyrosine kinase 2 0.0369192
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0367559
ANKHD1 ankyrin repeat and KH domain containing 1 0.0365439
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0364458
PSD3 pleckstrin and Sec7 domain containing 3 0.0354911
N4BP2L2 NEDD4 binding protein 2-like 2 0.0354036
HMGA1 high mobility group AT-hook 1 0.0345217
COG6 component of oligomeric golgi complex 6 0.0343363
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0338567
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0331543
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0331028
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.033088
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0330284
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0329805
RPS25 ribosomal protein S25 0.0329258
TTC3 tetratricopeptide repeat domain 3 0.0328338
PRSS23 protease, serine, 23 0.0328267
RNF217 ring finger protein 217 0.0328099
ARHGAP21 Rho GTPase activating protein 21 0.0326267
RICTOR RPTOR independent companion of MTOR, complex 2 0.0324152
SOS1 son of sevenless homolog 1 (Drosophila) 0.0322326
SVIL supervillin 0.0319531
RPL13A ribosomal protein L13a 0.0316959
SQSTM1 sequestosome 1 0.031503
DST dystonin 0.0313548
IRS2 insulin receptor substrate 2 0.030851
TIMP3 TIMP metallopeptidase inhibitor 3 0.0307845
RAB22A RAB22A, member RAS oncogene family 0.0307212
RAB2A RAB2A, member RAS oncogene family 0.0305557
BARX2 BARX homeobox 2 0.0303689
SULF2 sulfatase 2 0.0301338
ZCCHC7 zinc finger, CCHC domain containing 7 0.0301324
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0301044
SEPTIN9 septin 9 0.0299702
FTH1 ferritin, heavy polypeptide 1 0.0295328
MEF2A myocyte enhancer factor 2A 0.0293461
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0292912
ATM ATM serine/threonine kinase 0.0292688
BACE2 beta-site APP-cleaving enzyme 2 0.0291673
MT1E metallothionein 1E 0.0291282
UTRN utrophin 0.029063
COPA coatomer protein complex, subunit alpha 0.0289648
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0287909
MTDH metadherin 0.0285374
RPS13 ribosomal protein S13 0.0284998
ERBIN erbb2 interacting protein 0.0283359
WWTR1 WW domain containing transcription regulator 1 0.0282675
EGFR epidermal growth factor receptor 0.0282152
FOXO1 forkhead box O1 0.0280271

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.124015
FLNB filamin B, beta -0.112367
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0885122
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0868063
SAMD9 sterile alpha motif domain containing 9 -0.0790589
TMSB4X thymosin beta 4, X-linked -0.0683095
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0662995
NAMPT nicotinamide phosphoribosyltransferase -0.0631076
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.06085
TMSB10 thymosin beta 10 -0.0606746
POTEF POTE ankyrin domain family, member F -0.0600924
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0600076
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.057506
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0522635
H1-0 H1.0 linker histone -0.0498851
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0494052
IFI6 interferon, alpha-inducible protein 6 -0.0492379
CAV1 caveolin 1, caveolae protein, 22kDa -0.0481171
MKI67 marker of proliferation Ki-67 -0.0477941
ANLN anillin, actin binding protein -0.0464807
KRT17 keratin 17, type I -0.0463997
ITGA6 integrin, alpha 6 -0.0460791
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0459426
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0459138
MAML2 mastermind-like 2 (Drosophila) -0.0457348
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0449228
RIGI RNA sensor RIG-I -0.0442148
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0441068
STAT1 signal transducer and activator of transcription 1, 91kDa -0.042745
FOSL1 FOS-like antigen 1 -0.0425978
EMP1 epithelial membrane protein 1 -0.0399713
CENPF centromere protein F, 350/400kDa -0.039047
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0386505
EZR ezrin -0.0385771
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0384144
AHNAK AHNAK nucleoprotein -0.0379209
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0378521
MYO10 myosin X -0.0364053
TPX2 TPX2, microtubule-associated -0.0350985
IFITM3 interferon induced transmembrane protein 3 -0.0350861
DIAPH3 diaphanous-related formin 3 -0.0350223
SP100 SP100 nuclear antigen -0.0347834
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0340832
IFIH1 interferon induced with helicase C domain 1 -0.0336831
SAMD9L sterile alpha motif domain containing 9-like -0.0332831
S100A10 S100 calcium binding protein A10 -0.0331585
IFI27 interferon, alpha-inducible protein 27 -0.0328723
ZMYND8 zinc finger, MYND-type containing 8 -0.0328591
SULF1 sulfatase 1 -0.0326585
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0325957
IFI44L interferon-induced protein 44-like -0.0324511
EGR1 early growth response 1 -0.0318778
PLAT plasminogen activator, tissue -0.0318186
ISG15 ISG15 ubiquitin-like modifier -0.0316668
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0315121
S100A11 S100 calcium binding protein A11 -0.0314371
F3 coagulation factor III (thromboplastin, tissue factor) -0.0313401
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0311317
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0310908
S100A6 S100 calcium binding protein A6 -0.0307107
IFI44 interferon-induced protein 44 -0.0302075
IFITM1 interferon induced transmembrane protein 1 -0.029961
SPATS2 spermatogenesis associated, serine-rich 2 -0.0297081
PDIA3 protein disulfide isomerase family A, member 3 -0.0296477
ZNFX1 zinc finger, NFX1-type containing 1 -0.0292005
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0289836
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0289554
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0289546
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0289054
LAMC2 laminin, gamma 2 -0.0286402
MT1X metallothionein 1X -0.027405
MX1 MX dynamin-like GTPase 1 -0.027197
MYL12B myosin, light chain 12B, regulatory -0.0271221
ADAR adenosine deaminase, RNA-specific -0.0266173
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0264759
CSNK1E casein kinase 1, epsilon -0.0264454
CLU clusterin -0.0263842
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.02636
DPYD dihydropyrimidine dehydrogenase -0.025872
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0256447
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0253807
S100A2 S100 calcium binding protein A2 -0.0253259
PODXL podocalyxin-like -0.0252115
PFN1 profilin 1 -0.0249858
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.024736
SAMHD1 SAM domain and HD domain 1 -0.0240421
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.023671
AFAP1 actin filament associated protein 1 -0.0233969
COL17A1 collagen, type XVII, alpha 1 -0.0229744
YBX1 Y box binding protein 1 -0.0228099
TM4SF1 transmembrane 4 L six family member 1 -0.0224835
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0220231
ANO1 anoctamin 1, calcium activated chloride channel -0.0220188
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0218766
RPL35A ribosomal protein L35a -0.0217919
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.021748
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0213892
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0212524
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0211494
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0211316