| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ipatasertib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DSPP | dentin sialophosphoprotein | 0.143936 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.120582 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.116142 |
| RPS6 | ribosomal protein S6 | 0.111821 |
| MACC1 | metastasis associated in colon cancer 1 | 0.109527 |
| FTL | ferritin, light polypeptide | 0.0850775 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.083069 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0788656 |
| VEGFA | vascular endothelial growth factor A | 0.0768466 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0759977 |
| LCN2 | lipocalin 2 | 0.0746304 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.074201 |
| MACROD2 | MACRO domain containing 2 | 0.0679963 |
| TMC5 | transmembrane channel-like 5 | 0.0658704 |
| RPL35A | ribosomal protein L35a | 0.065271 |
| RAD51B | RAD51 paralog B | 0.0651127 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0626255 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.061582 |
| PRELID2 | PRELI domain containing 2 | 0.0586962 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.057766 |
| RPL23 | ribosomal protein L23 | 0.0576 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0565168 |
| ATF5 | activating transcription factor 5 | 0.0564234 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.054131 |
| B2M | beta-2-microglobulin | 0.0538048 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.05339 |
| CNKSR3 | CNKSR family member 3 | 0.053241 |
| TNS3 | tensin 3 | 0.0520023 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0514047 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0501325 |
| BPTF | bromodomain PHD finger transcription factor | 0.0497232 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0472187 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0446122 |
| FOXP1 | forkhead box P1 | 0.0431762 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0426275 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0421948 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0418019 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0415554 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0412759 |
| RPS25 | ribosomal protein S25 | 0.0412138 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0399088 |
| RPS8 | ribosomal protein S8 | 0.0396331 |
| TMEM45B | transmembrane protein 45B | 0.0382768 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.038255 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0380705 |
| CDK19 | cyclin-dependent kinase 19 | 0.0380072 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0379864 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0377001 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0376345 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0374163 |
| RPLP1 | ribosomal protein, large, P1 | 0.0373743 |
| RPS19 | ribosomal protein S19 | 0.037373 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0370249 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0368804 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0368334 |
| ANXA4 | annexin A4 | 0.0365365 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0364067 |
| RBM47 | RNA binding motif protein 47 | 0.0357892 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0356174 |
| RPS12 | ribosomal protein S12 | 0.0353073 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0350324 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.034973 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0349216 |
| DSTN | destrin (actin depolymerizing factor) | 0.034544 |
| TXNIP | thioredoxin interacting protein | 0.0336756 |
| ZNF395 | zinc finger protein 395 | 0.0334569 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0333701 |
| RPL30 | ribosomal protein L30 | 0.0332744 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0330999 |
| PCM1 | pericentriolar material 1 | 0.0330318 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0326441 |
| RPL19 | ribosomal protein L19 | 0.0320548 |
| NDRG1 | N-myc downstream regulated 1 | 0.0319202 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0312309 |
| ZNF292 | zinc finger protein 292 | 0.0311029 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0307841 |
| ITGB8 | integrin, beta 8 | 0.0302354 |
| PHF3 | PHD finger protein 3 | 0.029576 |
| RPL39 | ribosomal protein L39 | 0.0295605 |
| NFIB | nuclear factor I/B | 0.0291583 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0290422 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0288609 |
| POF1B | premature ovarian failure, 1B | 0.0286586 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0284626 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0284285 |
| TMEM123 | transmembrane protein 123 | 0.0283765 |
| PCBP2 | poly(rC) binding protein 2 | 0.0282927 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0277946 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | 0.027632 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0274814 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0271996 |
| EXOC4 | exocyst complex component 4 | 0.0271976 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0271294 |
| WWOX | WW domain containing oxidoreductase | 0.026935 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0267415 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0266034 |
| COBL | cordon-bleu WH2 repeat protein | 0.026313 |
| HKDC1 | hexokinase domain containing 1 | 0.0260559 |
| ZNF148 | zinc finger protein 148 | 0.0258114 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.025726 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.209124 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.202671 |
| NPSR1 | neuropeptide S receptor 1 | -0.158259 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.157961 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.146584 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0939535 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0894044 |
| EMP1 | epithelial membrane protein 1 | -0.0819457 |
| LMO7 | LIM domain 7 | -0.0813477 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0812203 |
| H1-0 | H1.0 linker histone | -0.0759537 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0743953 |
| KRT18 | keratin 18, type I | -0.0675686 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0653936 |
| EHBP1 | EH domain binding protein 1 | -0.0646554 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0516934 |
| KRT8 | keratin 8, type II | -0.0484535 |
| FLNB | filamin B, beta | -0.0484453 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0428435 |
| CANX | calnexin | -0.0405391 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0396377 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0384746 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.038317 |
| TFRC | transferrin receptor | -0.0375063 |
| FRMD5 | FERM domain containing 5 | -0.036783 |
| HYOU1 | hypoxia up-regulated 1 | -0.0365221 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0357325 |
| PRKCA | protein kinase C, alpha | -0.0338823 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0336577 |
| LAMB3 | laminin, beta 3 | -0.0336322 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0333794 |
| HDAC9 | histone deacetylase 9 | -0.0328754 |
| FAT1 | FAT atypical cadherin 1 | -0.0325339 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0323115 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0303197 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0300495 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0300153 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0297916 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0297379 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0288009 |
| TOP1 | topoisomerase (DNA) I | -0.0280268 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0279412 |
| BCL2L1 | BCL2-like 1 | -0.0277209 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.027546 |
| RBM39 | RNA binding motif protein 39 | -0.0275315 |
| CLTC | clathrin, heavy chain (Hc) | -0.0264667 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0263319 |
| ECT2 | epithelial cell transforming 2 | -0.0256803 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0254954 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0252818 |
| ANLN | anillin, actin binding protein | -0.0252457 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0246616 |
| CAPN8 | calpain 8 | -0.0242439 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0241844 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0235598 |
| ITGA6 | integrin, alpha 6 | -0.0233832 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0233668 |
| ANXA2 | annexin A2 | -0.0227801 |
| PMM2 | phosphomannomutase 2 | -0.022586 |
| CDK6 | cyclin-dependent kinase 6 | -0.0224749 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0223508 |
| CCDC47 | coiled-coil domain containing 47 | -0.0221853 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0218313 |
| PLSCR1 | phospholipid scramblase 1 | -0.0217523 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0217187 |
| IRF1 | interferon regulatory factor 1 | -0.0215318 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0213368 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0212995 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0212121 |
| PKP4 | plakophilin 4 | -0.021158 |
| CCNL1 | cyclin L1 | -0.0211509 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0211443 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0204952 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0202354 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0202108 |
| KRT7 | keratin 7, type II | -0.0201695 |
| FASN | fatty acid synthase | -0.020108 |
| SETX | senataxin | -0.0197953 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0197874 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0196037 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0196009 |
| TMSB4X | thymosin beta 4, X-linked | -0.0195804 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0195691 |
| SRPRA | SRP receptor subunit alpha | -0.0195179 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0193126 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0192747 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0192657 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0191833 |
| HDLBP | high density lipoprotein binding protein | -0.0190804 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.018996 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0189382 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0188499 |
| HLA-C | major histocompatibility complex, class I, C | -0.018806 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0186818 |
| SH3D19 | SH3 domain containing 19 | -0.018672 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0185894 |
| MUC17 | mucin 17, cell surface associated | -0.0185815 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0185679 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0184549 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0183396 |
