Ipatasertib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.113186
RPS12 ribosomal protein S12 0.0845449
RPS6 ribosomal protein S6 0.0710439
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0575362
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0564622
RPL36 ribosomal protein L36 0.0526289
RPLP2 ribosomal protein, large, P2 0.0499388
RPS3 ribosomal protein S3 0.0491287
RPL9 ribosomal protein L9 0.0488168
MBNL1 muscleblind-like splicing regulator 1 0.0479024
NEBL nebulette 0.0476294
RPS8 ribosomal protein S8 0.0474588
VEGFA vascular endothelial growth factor A 0.0454611
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0448657
TXNIP thioredoxin interacting protein 0.0443194
NDRG1 N-myc downstream regulated 1 0.0429256
RPL5 ribosomal protein L5 0.0415368
RPS29 ribosomal protein S29 0.0407029
RPL31 ribosomal protein L31 0.0398745
AFF1 AF4/FMR2 family, member 1 0.0396023
PTEN phosphatase and tensin homolog 0.039594
TPT1 tumor protein, translationally-controlled 1 0.0385805
MED13L mediator complex subunit 13-like 0.0373379
AKAP9 A kinase (PRKA) anchor protein 9 0.0368818
CADPS Ca++-dependent secretion activator 0.0337675
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0334428
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0327514
RPL37A ribosomal protein L37a 0.0326812
GOLGA4 golgin A4 0.0323983
ARL15 ADP-ribosylation factor-like 15 0.0321441
ZBTB20 zinc finger and BTB domain containing 20 0.0321437
RPL26 ribosomal protein L26 0.0321316
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0319297
FOXP1 forkhead box P1 0.0318884
B2M beta-2-microglobulin 0.0314322
ATXN1 ataxin 1 0.0312482
RPS13 ribosomal protein S13 0.0312277
N4BP2L2 NEDD4 binding protein 2-like 2 0.0311698
PNISR PNN-interacting serine/arginine-rich protein 0.0311003
MBD5 methyl-CpG binding domain protein 5 0.0309521
ANKRD12 ankyrin repeat domain 12 0.0297085
RNF145 ring finger protein 145 0.0296933
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0296332
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0294309
TBC1D5 TBC1 domain family, member 5 0.0291674
RPL13A ribosomal protein L13a 0.0288699
EIF1 eukaryotic translation initiation factor 1 0.0286688
FBXL17 F-box and leucine-rich repeat protein 17 0.0283398
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.028071
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0280245
TNRC6B trinucleotide repeat containing 6B 0.0272599
RPS25 ribosomal protein S25 0.026681
PCBP2 poly(rC) binding protein 2 0.026361
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0257506
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0257429
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0254919
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.025355
ANKRD17 ankyrin repeat domain 17 0.0252686
FTL ferritin, light polypeptide 0.0252294
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0250495
EXT1 exostosin glycosyltransferase 1 0.0250261
WAC WW domain containing adaptor with coiled-coil 0.0249941
ERBIN erbb2 interacting protein 0.0241714
RPL36A ribosomal protein L36a 0.0237868
DSCAM Down syndrome cell adhesion molecule 0.0237024
RAD51B RAD51 paralog B 0.0235471
DENND4C DENN/MADD domain containing 4C 0.0233395
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0230718
RAB7A RAB7A, member RAS oncogene family 0.023025
ARB2A ARB2 cotranscriptional regulator A 0.0229157
ANKHD1 ankyrin repeat and KH domain containing 1 0.0228951
BIRC6 baculoviral IAP repeat containing 6 0.0222498
SETD5 SET domain containing 5 0.0222356
RAB6A RAB6A, member RAS oncogene family 0.0222174
ANKRD11 ankyrin repeat domain 11 0.0221353
SPRED2 sprouty-related, EVH1 domain containing 2 0.0220453
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0220301
RPL28 ribosomal protein L28 0.0219139
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0218957
MON2 MON2 homolog (S. cerevisiae) 0.0218395
BBX bobby sox homolog (Drosophila) 0.0217722
FNDC3A fibronectin type III domain containing 3A 0.0215884
FNIP1 folliculin interacting protein 1 0.0214368
ZFAND3 zinc finger, AN1-type domain 3 0.0214151
BBS9 Bardet-Biedl syndrome 9 0.0212672
RPS23 ribosomal protein S23 0.0212587
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0211619
NF1 neurofibromin 1 0.0211213
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.02112
RBM25 RNA binding motif protein 25 0.0209833
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0209223
DNM2 dynamin 2 0.020828
SATB2 SATB homeobox 2 0.020499
ZNF292 zinc finger protein 292 0.0203725
TRIM2 tripartite motif containing 2 0.0203202
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0202709
NUCB2 nucleobindin 2 0.0202451
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0201898
RNF43 ring finger protein 43 0.0200282
RPL11 ribosomal protein L11 0.0200264

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.238277
NPSR1 neuropeptide S receptor 1 -0.236927
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.200287
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.200223
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.15414
KRT18 keratin 18, type I -0.130576
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126377
AHNAK AHNAK nucleoprotein -0.115129
TMSB10 thymosin beta 10 -0.0976556
ANXA2 annexin A2 -0.0919081
ITGA6 integrin, alpha 6 -0.0742588
FAT1 FAT atypical cadherin 1 -0.0719548
KRT8 keratin 8, type II -0.0711075
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0695782
GMDS GDP-mannose 4,6-dehydratase -0.0664396
S100A6 S100 calcium binding protein A6 -0.064893
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0625565
TPM4 tropomyosin 4 -0.0622421
ACTG1 actin gamma 1 -0.0554424
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0529726
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0523177
SLC35F3 solute carrier family 35, member F3 -0.051557
H1-0 H1.0 linker histone -0.0510881
MYO1E myosin IE -0.0498243
DSPP dentin sialophosphoprotein -0.0493635
PSD3 pleckstrin and Sec7 domain containing 3 -0.0492851
LDHA lactate dehydrogenase A -0.0483647
FLNB filamin B, beta -0.0470965
LAMA4 laminin, alpha 4 -0.0468568
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0451713
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0446038
IER3 immediate early response 3 -0.0444443
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0433418
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0420707
FERMT1 fermitin family member 1 -0.0419755
PGK1 phosphoglycerate kinase 1 -0.0409725
F3 coagulation factor III (thromboplastin, tissue factor) -0.0397562
TFF1 trefoil factor 1 -0.0397264
EZR ezrin -0.0393189
RNF217 ring finger protein 217 -0.0393085
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0391929
GREB1L growth regulation by estrogen in breast cancer-like -0.0390395
ACTN4 actinin, alpha 4 -0.0360711
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0356693
ANTXR2 anthrax toxin receptor 2 -0.0350488
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0346987
CANX calnexin -0.0337119
MUC17 mucin 17, cell surface associated -0.0335959
VCL vinculin -0.0326566
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0325982
SOX4 SRY (sex determining region Y)-box 4 -0.0312972
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0312746
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0312255
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0311795
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0310906
LSAMP limbic system-associated membrane protein -0.0302652
ASPH aspartate beta-hydroxylase -0.0301369
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.030048
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0296414
AGR2 anterior gradient 2 -0.0292316
NRN1 neuritin 1 -0.0290024
CLTC clathrin, heavy chain (Hc) -0.0284353
EPCAM epithelial cell adhesion molecule -0.0283232
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0281594
LOC112694756 uncharaterized LOC112694756 -0.0280738
HMGB1 high mobility group box 1 -0.0279926
LAMB3 laminin, beta 3 -0.0274202
POTEF POTE ankyrin domain family, member F -0.0272332
KLF5 Kruppel-like factor 5 (intestinal) -0.027224
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0271792
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0270428
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0269654
ABLIM1 actin binding LIM protein 1 -0.0252656
CALB1 calbindin 1, 28kDa -0.025029
BZW1 basic leucine zipper and W2 domains 1 -0.0242868
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0242805
ARHGAP6 Rho GTPase activating protein 6 -0.0240848
MAML2 mastermind-like 2 (Drosophila) -0.0235974
KLK10 kallikrein-related peptidase 10 -0.0233341
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0232761
BTG1 B-cell translocation gene 1, anti-proliferative -0.0231285
KRT19 keratin 19, type I -0.0228735
SVIL supervillin -0.0228696
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0227168
HDLBP high density lipoprotein binding protein -0.0226952
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0222851
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0217067
TFF3 trefoil factor 3 (intestinal) -0.0216884
KIF5B kinesin family member 5B -0.0210457
RAD21 RAD21 homolog (S. pombe) -0.0210427
HDAC2 histone deacetylase 2 -0.0203882
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.020352
TMSB4X thymosin beta 4, X-linked -0.0202419
DSG2 desmoglein 2 -0.0201205
CEMIP cell migration inducing protein, hyaluronan binding -0.0199022
YBX1 Y box binding protein 1 -0.0198773
RESF1 retroelement silencing factor 1 -0.019579
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.01918
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0191288
CENPF centromere protein F, 350/400kDa -0.0190345