Ipatasertib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA1 high mobility group AT-hook 1 0.128476
RPS12 ribosomal protein S12 0.097566
PSD3 pleckstrin and Sec7 domain containing 3 0.0971805
WWTR1 WW domain containing transcription regulator 1 0.09113
RPS8 ribosomal protein S8 0.0891341
RUNX1 runt-related transcription factor 1 0.088444
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0765004
RPS6 ribosomal protein S6 0.0737326
RPL5 ribosomal protein L5 0.0715418
RPL31 ribosomal protein L31 0.0686633
BICD1 bicaudal D homolog 1 (Drosophila) 0.0647491
PODXL podocalyxin-like 0.0621496
MT2A metallothionein 2A 0.0609512
SDCCAG8 serologically defined colon cancer antigen 8 0.0582408
RPL36 ribosomal protein L36 0.0557796
EMP1 epithelial membrane protein 1 0.0550796
RPS29 ribosomal protein S29 0.0550047
CAPRIN2 caprin family member 2 0.0527639
RPL37A ribosomal protein L37a 0.0515215
RPS3 ribosomal protein S3 0.0514757
BCAR3 breast cancer anti-estrogen resistance 3 0.0513423
CAPN2 calpain 2, (m/II) large subunit 0.0476499
MBNL1 muscleblind-like splicing regulator 1 0.0460476
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0453243
FTL ferritin, light polypeptide 0.0445879
RAB7A RAB7A, member RAS oncogene family 0.0443861
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0438936
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0419042
DPYD dihydropyrimidine dehydrogenase 0.0412332
RPLP2 ribosomal protein, large, P2 0.0405431
RPL9 ribosomal protein L9 0.0404797
RPS13 ribosomal protein S13 0.0404265
TPT1 tumor protein, translationally-controlled 1 0.0394033
RPS25 ribosomal protein S25 0.0388834
PYGB phosphorylase, glycogen; brain 0.0385417
RPS23 ribosomal protein S23 0.0382974
RPS10 ribosomal protein S10 0.0378227
KTN1 kinectin 1 (kinesin receptor) 0.0377689
RPL26 ribosomal protein L26 0.0368822
RAB27B RAB27B, member RAS oncogene family 0.0363213
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0357599
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0354983
NTSR1 neurotensin receptor 1 (high affinity) 0.0350424
RPL36A ribosomal protein L36a 0.0343171
RPS17 ribosomal protein S17 0.0340669
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.033792
SMYD3 SET and MYND domain containing 3 0.0337581
RAP2B RAP2B, member of RAS oncogene family 0.0336594
ITGB4 integrin, beta 4 0.0327874
TIMP2 TIMP metallopeptidase inhibitor 2 0.0325123
RPL13A ribosomal protein L13a 0.0325054
ANKRD12 ankyrin repeat domain 12 0.0320261
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0315718
RACK1 receptor for activated C kinase 1 0.0312801
ZDHHC14 zinc finger, DHHC-type containing 14 0.0311458
RPLP1 ribosomal protein, large, P1 0.0309252
RPL27 ribosomal protein L27 0.0304135
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0301762
GCLM glutamate-cysteine ligase, modifier subunit 0.0295559
RPS27A ribosomal protein S27a 0.0293971
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0288647
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0283236
RPL7A ribosomal protein L7a 0.0282791
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0280517
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0273068
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0270846
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0268223
ANXA2 annexin A2 0.0264647
TTC3 tetratricopeptide repeat domain 3 0.0264142
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.02634
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0254949
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.0253571
CSNK1A1 casein kinase 1, alpha 1 0.0252316
RPL28 ribosomal protein L28 0.025185
FMNL2 formin-like 2 0.0250906
NPAS2 neuronal PAS domain protein 2 0.025035
ZEB1 zinc finger E-box binding homeobox 1 0.024982
IARS1 isoleucyl-tRNA synthetase 1 0.0247013
AKAP9 A kinase (PRKA) anchor protein 9 0.0242529
PCBP2 poly(rC) binding protein 2 0.0239804
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0236555
SEPTIN9 septin 9 0.0235466
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.023297
RPL37 ribosomal protein L37 0.0230328
DOCK5 dedicator of cytokinesis 5 0.0225311
CADM2 cell adhesion molecule 2 0.0221617
WNK1 WNK lysine deficient protein kinase 1 0.0221118
FOSL1 FOS-like antigen 1 0.0216545
PCDH1 protocadherin 1 0.0213293
SH3TC2 SH3 domain and tetratricopeptide repeats 2 0.0207714
TBCA tubulin folding cofactor A 0.0204178
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0203982
ERBIN erbb2 interacting protein 0.0203831
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0201759
RNF182 ring finger protein 182 0.0199865
TSC22D1 TSC22 domain family, member 1 0.0199538
DOCK11 dedicator of cytokinesis 11 0.0198212
RPS27 ribosomal protein S27 0.0195778
CD44 CD44 molecule (Indian blood group) 0.0195406
TOP1 topoisomerase (DNA) I 0.01946

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.184191
ERRFI1 ERBB receptor feedback inhibitor 1 -0.145622
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.144389
TMSB4X thymosin beta 4, X-linked -0.142907
DST dystonin -0.140207
PTMA prothymosin, alpha -0.137013
STAT1 signal transducer and activator of transcription 1, 91kDa -0.12557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11371
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.107245
CANX calnexin -0.104513
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0973062
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0935352
HLA-B major histocompatibility complex, class I, B -0.0887682
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0883194
WARS1 tryptophanyl-tRNA synthetase 1 -0.0872443
SRGN serglycin -0.0847929
SOD2 superoxide dismutase 2, mitochondrial -0.0785721
RIGI RNA sensor RIG-I -0.0782514
ZNF217 zinc finger protein 217 -0.0747191
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0739918
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0724665
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0723223
TMSB10 thymosin beta 10 -0.0715544
TM4SF1 transmembrane 4 L six family member 1 -0.0677359
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0667994
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0659255
ZMYND8 zinc finger, MYND-type containing 8 -0.0641482
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0641029
IFIH1 interferon induced with helicase C domain 1 -0.0617555
PDE10A phosphodiesterase 10A -0.0600347
BIRC3 baculoviral IAP repeat containing 3 -0.0549539
RNF213 ring finger protein 213 -0.0544748
TNS3 tensin 3 -0.0539755
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0534548
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0524132
SPAG9 sperm associated antigen 9 -0.0481108
LOXL2 lysyl oxidase-like 2 -0.0480662
RAI1 retinoic acid induced 1 -0.0480347
SDC4 syndecan 4 -0.047755
NAMPT nicotinamide phosphoribosyltransferase -0.0474999
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0464958
EFNA5 ephrin-A5 -0.0461177
CENPF centromere protein F, 350/400kDa -0.0456357
EREG epiregulin -0.0455888
TRIO trio Rho guanine nucleotide exchange factor -0.0437921
KDM3A lysine (K)-specific demethylase 3A -0.0423
PLSCR1 phospholipid scramblase 1 -0.0422362
ADAM10 ADAM metallopeptidase domain 10 -0.0420653
IFI6 interferon, alpha-inducible protein 6 -0.0412772
PGK1 phosphoglycerate kinase 1 -0.0407528
TMEM123 transmembrane protein 123 -0.0407221
HDLBP high density lipoprotein binding protein -0.0405295
LOC112694756 uncharaterized LOC112694756 -0.0404006
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0395526
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0392975
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0392352
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0390418
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0381019
VCL vinculin -0.0362975
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0354288
MYOF myoferlin -0.0354233
ZNFX1 zinc finger, NFX1-type containing 1 -0.0343016
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0337946
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0335359
LRRC49 leucine rich repeat containing 49 -0.032605
H1-0 H1.0 linker histone -0.0323592
BIRC2 baculoviral IAP repeat containing 2 -0.0314177
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0313298
VMP1 vacuole membrane protein 1 -0.0311439
PDIA3 protein disulfide isomerase family A, member 3 -0.0299103
COL5A2 collagen, type V, alpha 2 -0.0299073
ANXA1 annexin A1 -0.0296763
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0293011
TGM2 transglutaminase 2 -0.0291918
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0289301
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0288603
SRRM2 serine/arginine repetitive matrix 2 -0.0279085
SP100 SP100 nuclear antigen -0.0272453
DNER delta/notch-like EGF repeat containing -0.0271551
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0269487
LDHA lactate dehydrogenase A -0.0269123
ARHGAP5 Rho GTPase activating protein 5 -0.0267356
PLIN2 perilipin 2 -0.0267308
MYH9 myosin, heavy chain 9, non-muscle -0.0264104
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0263942
HLA-E major histocompatibility complex, class I, E -0.0263756
CCDC47 coiled-coil domain containing 47 -0.0262875
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.026097
CAMTA1 calmodulin binding transcription activator 1 -0.0259744
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.025964
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0258678
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0258451
IFITM1 interferon induced transmembrane protein 1 -0.0255869
CLTC clathrin, heavy chain (Hc) -0.0255004
EZR ezrin -0.0250608
ANLN anillin, actin binding protein -0.024563
CDK12 cyclin-dependent kinase 12 -0.0244631
HOOK2 hook microtubule-tethering protein 2 -0.0242822
B2M beta-2-microglobulin -0.0240939
DENND1A DENN/MADD domain containing 1A -0.0240706