Ipatasertib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.314982
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.30873
ASPH aspartate beta-hydroxylase 0.109092
MYOF myoferlin 0.106588
MCTP1 multiple C2 domains, transmembrane 1 0.103422
DOCK5 dedicator of cytokinesis 5 0.102019
RPS3 ribosomal protein S3 0.101971
MT2A metallothionein 2A 0.0944015
TPT1 tumor protein, translationally-controlled 1 0.0926061
PDE4D phosphodiesterase 4D, cAMP-specific 0.0907287
SMYD3 SET and MYND domain containing 3 0.0875068
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0837019
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0789426
EFNA5 ephrin-A5 0.0775104
CCND1 cyclin D1 0.0687703
TXNRD1 thioredoxin reductase 1 0.0683655
RPLP1 ribosomal protein, large, P1 0.0672581
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0638609
RPL37A ribosomal protein L37a 0.0610974
RPS8 ribosomal protein S8 0.059831
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0594906
RPS25 ribosomal protein S25 0.0591646
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0577277
ENO1 enolase 1, (alpha) 0.0554642
RPS6 ribosomal protein S6 0.0548033
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0540187
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0529339
FOXP1 forkhead box P1 0.0527161
RPS12 ribosomal protein S12 0.0521437
NPAS2 neuronal PAS domain protein 2 0.0515755
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0508132
RPL31 ribosomal protein L31 0.0505301
LGALS12 lectin, galactoside-binding, soluble, 12 0.0492281
SLTM SAFB-like, transcription modulator 0.0485932
ANXA2 annexin A2 0.0479931
RPL5 ribosomal protein L5 0.047751
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0474953
RPLP0 ribosomal protein, large, P0 0.0471961
RPS24 ribosomal protein S24 0.0460518
SLC38A2 solute carrier family 38, member 2 0.0455987
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0453081
PKM pyruvate kinase, muscle 0.0440874
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0438416
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0437597
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0434335
LRP12 low density lipoprotein receptor-related protein 12 0.0419385
LPP LIM domain containing preferred translocation partner in lipoma 0.0418354
RPS17 ribosomal protein S17 0.0415811
RPS27A ribosomal protein S27a 0.0411545
MBNL1 muscleblind-like splicing regulator 1 0.0411293
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0410077
ANKRD17 ankyrin repeat domain 17 0.0406939
BPTF bromodomain PHD finger transcription factor 0.0404398
RPS29 ribosomal protein S29 0.0403389
PM20D1 peptidase M20 domain containing 1 0.0399883
FAF1 Fas (TNFRSF6) associated factor 1 0.0398763
NTSR1 neurotensin receptor 1 (high affinity) 0.0389624
RPL9 ribosomal protein L9 0.0389248
CPE carboxypeptidase E 0.0380706
GPHN gephyrin 0.0375333
IGF1R insulin-like growth factor 1 receptor 0.037514
RPL37 ribosomal protein L37 0.0374073
IRS2 insulin receptor substrate 2 0.0371797
AGO2 argonaute RISC catalytic component 2 0.0368736
RPS23 ribosomal protein S23 0.036805
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.036681
PTPRM protein tyrosine phosphatase, receptor type, M 0.0359414
CCSER1 coiled-coil serine-rich protein 1 0.0358728
PDLIM5 PDZ and LIM domain 5 0.0358606
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0356342
THSD4 thrombospondin, type I, domain containing 4 0.0347803
RPL30 ribosomal protein L30 0.0347388
EXT1 exostosin glycosyltransferase 1 0.0343251
RPL36 ribosomal protein L36 0.0342928
RPL19 ribosomal protein L19 0.03416
MGST1 microsomal glutathione S-transferase 1 0.0336325
TNRC6B trinucleotide repeat containing 6B 0.0332638
RAB10 RAB10, member RAS oncogene family 0.0332096
UGDH UDP-glucose 6-dehydrogenase 0.0332073
SCEL sciellin 0.0321748
S100P S100 calcium binding protein P 0.0317902
AHR aryl hydrocarbon receptor 0.0316769
TBC1D22A TBC1 domain family, member 22A 0.0315027
FBXL17 F-box and leucine-rich repeat protein 17 0.0310757
RPL34 ribosomal protein L34 0.0306511
RPLP2 ribosomal protein, large, P2 0.0306125
DENND5B DENN/MADD domain containing 5B 0.0298338
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0297736
WWOX WW domain containing oxidoreductase 0.0296323
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0288137
GCLC glutamate-cysteine ligase, catalytic subunit 0.0287737
AKAP9 A kinase (PRKA) anchor protein 9 0.0287424
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0285247
TES testin LIM domain protein 0.0284952
RACK1 receptor for activated C kinase 1 0.0284739
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0283404
RPL35A ribosomal protein L35a 0.0280959
RBM25 RNA binding motif protein 25 0.0280422
RPS21 ribosomal protein S21 0.0277658
RPL11 ribosomal protein L11 0.0277657

decreased expression

Symbol Name Standardized Value
LAMC2 laminin, gamma 2 -0.0799288
NAMPT nicotinamide phosphoribosyltransferase -0.0703986
SOD2 superoxide dismutase 2, mitochondrial -0.0631966
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0562498
SPAG9 sperm associated antigen 9 -0.0524124
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0505018
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0499991
H1-0 H1.0 linker histone -0.0493623
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.047892
CAMTA1 calmodulin binding transcription activator 1 -0.0422958
NGLY1 N-glycanase 1 -0.0412758
ELL2 elongation factor, RNA polymerase II, 2 -0.0390806
EGR1 early growth response 1 -0.0376863
STAT1 signal transducer and activator of transcription 1, 91kDa -0.035186
FAM13A family with sequence similarity 13, member A -0.0333207
ARRDC3 arrestin domain containing 3 -0.0328091
AKR1C1 aldo-keto reductase family 1, member C1 -0.0318868
DTNA dystrobrevin, alpha -0.0307004
GSK3B glycogen synthase kinase 3 beta -0.0268123
STC1 stanniocalcin 1 -0.0263331
KMT2E lysine (K)-specific methyltransferase 2E -0.0261943
MYH9 myosin, heavy chain 9, non-muscle -0.0260882
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0254776
LAMB3 laminin, beta 3 -0.0252289
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.025103
KDM3A lysine (K)-specific demethylase 3A -0.0249866
TSC22D2 TSC22 domain family, member 2 -0.0248111
BIRC3 baculoviral IAP repeat containing 3 -0.0245432
HOOK2 hook microtubule-tethering protein 2 -0.0240697
SUCO SUN domain containing ossification factor -0.0240206
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0237814
NDRG1 N-myc downstream regulated 1 -0.0232214
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0229508
BTG1 B-cell translocation gene 1, anti-proliferative -0.0222113
ERRFI1 ERBB receptor feedback inhibitor 1 -0.022091
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.021394
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0210616
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0209739
CYLD cylindromatosis (turban tumor syndrome) -0.0204951
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0203012
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0202895
BRWD3 bromodomain and WD repeat domain containing 3 -0.02011
GLS2 glutaminase 2 (liver, mitochondrial) -0.0195199
GRB10 growth factor receptor-bound protein 10 -0.0191161
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0190104
ADAM17 ADAM metallopeptidase domain 17 -0.0188614
CCNL1 cyclin L1 -0.0184467
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0184118
IGFBP3 insulin-like growth factor binding protein 3 -0.0183805
JUN jun proto-oncogene -0.0182964
AKAP12 A kinase (PRKA) anchor protein 12 -0.0181613
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0179279
USP53 ubiquitin specific peptidase 53 -0.0179197
ZMYND8 zinc finger, MYND-type containing 8 -0.0176625
BMAL2 basic helix-loop-helix ARNT like 2 -0.0175846
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0174297
UBC ubiquitin C -0.0172035
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.01706
ARL5B ADP-ribosylation factor-like 5B -0.016959
HILPDA hypoxia inducible lipid droplet-associated -0.0169211
DENND4A DENN/MADD domain containing 4A -0.016875
RAP1B RAP1B, member of RAS oncogene family -0.0167858
MACF1 microtubule-actin crosslinking factor 1 -0.0167683
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0166796
FRY furry homolog (Drosophila) -0.0164881
MXI1 MAX interactor 1, dimerization protein -0.0164306
LMO7 LIM domain 7 -0.0163293
FTH1 ferritin, heavy polypeptide 1 -0.0162661
KYNU kynureninase -0.0161583
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0161561
MYO5B myosin VB -0.0157729
ATG14 autophagy related 14 -0.0157613
TNIP1 TNFAIP3 interacting protein 1 -0.0157285
WDR45B WD repeat domain 45B -0.0155992
ZFC3H1 zinc finger, C3H1-type containing -0.0154555
CES1 carboxylesterase 1 -0.0153817
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.014969
IFI6 interferon, alpha-inducible protein 6 -0.0148434
SREBF2 sterol regulatory element binding transcription factor 2 -0.0146143
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0146066
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0146046
ATP13A3 ATPase type 13A3 -0.0145678
KDM5B lysine (K)-specific demethylase 5B -0.0145277
MXD1 MAX dimerization protein 1 -0.0144637
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0142216
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0141935
MARF1 meiosis regulator and mRNA stability factor 1 -0.0139698
WASF2 WAS protein family, member 2 -0.0139015
SAMD4A sterile alpha motif domain containing 4A -0.0137694
KDM6A lysine (K)-specific demethylase 6A -0.0137298
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0134332
ZNF217 zinc finger protein 217 -0.0133511
MSN moesin -0.0131377
NUP58 nucleoporin 58 -0.0130293
ZBTB10 zinc finger and BTB domain containing 10 -0.0129165
ATG7 autophagy related 7 -0.0128754
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0127435
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0127249
IFNAR2 interferon (alpha, beta and omega) receptor 2 -0.0126687
HBP1 HMG-box transcription factor 1 -0.0126478