Ipatasertib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.170269
CD44 CD44 molecule (Indian blood group) 0.10006
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0803371
NDRG1 N-myc downstream regulated 1 0.0794138
EGFR epidermal growth factor receptor 0.0766212
HMGA2 high mobility group AT-hook 2 0.0760685
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0758862
HMGA1 high mobility group AT-hook 1 0.0713226
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0669798
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0655549
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0630596
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0612451
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0601898
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0600161
NAV2 neuron navigator 2 0.0598198
CA12 carbonic anhydrase XII 0.055199
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0542132
ANTXR2 anthrax toxin receptor 2 0.0513732
ANGPTL4 angiopoietin-like 4 0.0503296
ASPH aspartate beta-hydroxylase 0.049408
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0484483
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0479251
MT2A metallothionein 2A 0.0476288
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.04637
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0455944
RPS12 ribosomal protein S12 0.0454939
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0449289
EFNA5 ephrin-A5 0.0442039
RPS8 ribosomal protein S8 0.0436855
ECE1 endothelin converting enzyme 1 0.0426416
VEGFA vascular endothelial growth factor A 0.0425324
RPS6 ribosomal protein S6 0.0413934
B2M beta-2-microglobulin 0.0408403
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0406591
ZSWIM6 zinc finger, SWIM-type containing 6 0.0403007
MAML3 mastermind-like 3 (Drosophila) 0.0400134
PKM pyruvate kinase, muscle 0.0390011
CDH13 cadherin 13 0.0387427
MBNL1 muscleblind-like splicing regulator 1 0.0383977
SEPTIN9 septin 9 0.0374316
LOX lysyl oxidase 0.0373316
PRKCA protein kinase C, alpha 0.0371415
RAD51B RAD51 paralog B 0.0370856
TGM2 transglutaminase 2 0.0365381
RPL5 ribosomal protein L5 0.0363225
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0355434
RPL31 ribosomal protein L31 0.0350983
ATXN1 ataxin 1 0.0348982
SYT1 synaptotagmin I 0.0333261
CAPN2 calpain 2, (m/II) large subunit 0.0328956
RPS29 ribosomal protein S29 0.0327962
EXT1 exostosin glycosyltransferase 1 0.0319644
PCDH7 protocadherin 7 0.0314101
BPTF bromodomain PHD finger transcription factor 0.0312534
MYO10 myosin X 0.031252
RPS17 ribosomal protein S17 0.0311896
ANKRD28 ankyrin repeat domain 28 0.0308829
SVIL supervillin 0.0300521
TIMP1 TIMP metallopeptidase inhibitor 1 0.0300035
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0299028
WWTR1 WW domain containing transcription regulator 1 0.0296499
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.029208
NRP1 neuropilin 1 0.0291991
SDK1 sidekick cell adhesion molecule 1 0.0291549
BACE2 beta-site APP-cleaving enzyme 2 0.0290591
S100A10 S100 calcium binding protein A10 0.0278888
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0278301
RPL37A ribosomal protein L37a 0.0277928
MYADM myeloid-associated differentiation marker 0.027739
TIMP2 TIMP metallopeptidase inhibitor 2 0.0273813
KTN1 kinectin 1 (kinesin receptor) 0.0273519
RPS3 ribosomal protein S3 0.02697
EGR1 early growth response 1 0.0266964
PCBP2 poly(rC) binding protein 2 0.0266878
RUNX1 runt-related transcription factor 1 0.0266498
IFI6 interferon, alpha-inducible protein 6 0.0266277
EHBP1 EH domain binding protein 1 0.0264362
GPC6 glypican 6 0.0262629
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0262294
ALCAM activated leukocyte cell adhesion molecule 0.025684
PRSS23 protease, serine, 23 0.0256254
RPL36 ribosomal protein L36 0.0254448
RPS27 ribosomal protein S27 0.0253431
INTS6 integrator complex subunit 6 0.0250782
SFTPA2 surfactant protein A2 0.0248053
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0247929
RPL9 ribosomal protein L9 0.0241328
TGFB1 transforming growth factor, beta 1 0.0240105
SQSTM1 sequestosome 1 0.0239993
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0237383
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0234795
LRMDA leucine rich melanocyte differentiation associated 0.0233829
SYNJ2 synaptojanin 2 0.0233214
RNASEH2A ribonuclease H2, subunit A 0.0228612
RPS25 ribosomal protein S25 0.0228061
DST dystonin 0.0227966
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.022744
MAST4 microtubule associated serine/threonine kinase family member 4 0.0225563
LDHA lactate dehydrogenase A 0.0225171
LOXL2 lysyl oxidase-like 2 0.0224253

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.225758
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.216615
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.165158
CXCL8 chemokine (C-X-C motif) ligand 8 -0.101709
RBM39 RNA binding motif protein 39 -0.0933373
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0847425
KDM3A lysine (K)-specific demethylase 3A -0.0786369
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0651124
GOLGA4 golgin A4 -0.0575172
CANX calnexin -0.0562094
SOD2 superoxide dismutase 2, mitochondrial -0.055996
FAM13A family with sequence similarity 13, member A -0.0534492
ELL2 elongation factor, RNA polymerase II, 2 -0.0533412
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0517761
OGA O-GlcNAcase -0.050173
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0489306
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0477335
RICTOR RPTOR independent companion of MTOR, complex 2 -0.046863
LMAN1 lectin, mannose-binding, 1 -0.0449381
KMT2C lysine (K)-specific methyltransferase 2C -0.0446578
PTMA prothymosin, alpha -0.0425224
USP3 ubiquitin specific peptidase 3 -0.0419985
BASP1 brain abundant, membrane attached signal protein 1 -0.0405939
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0402154
RAB1A RAB1A, member RAS oncogene family -0.0397561
IER3 immediate early response 3 -0.0392619
ZEB2 zinc finger E-box binding homeobox 2 -0.0380954
TMSB10 thymosin beta 10 -0.0380659
H1-0 H1.0 linker histone -0.0374295
MARCHF6 membrane associated ring-CH-type finger 6 -0.0371078
STRN3 striatin, calmodulin binding protein 3 -0.0367216
ATP13A3 ATPase type 13A3 -0.0345445
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0343908
SPAG9 sperm associated antigen 9 -0.034274
PDE4D phosphodiesterase 4D, cAMP-specific -0.0336676
PID1 phosphotyrosine interaction domain containing 1 -0.029915
NPEPPS aminopeptidase puromycin sensitive -0.0297772
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0290482
YBX1 Y box binding protein 1 -0.0284879
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0283463
LCORL ligand dependent nuclear receptor corepressor-like -0.0283143
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0282574
RUNX2 runt-related transcription factor 2 -0.0281162
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0280964
PDIA4 protein disulfide isomerase family A, member 4 -0.0276052
TMEM263 transmembrane protein 263 -0.026802
ZFAND3 zinc finger, AN1-type domain 3 -0.0266604
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0253053
OXSR1 oxidative stress responsive 1 -0.0252066
IGFBP3 insulin-like growth factor binding protein 3 -0.025131
WDR45B WD repeat domain 45B -0.0251147
COG5 component of oligomeric golgi complex 5 -0.0249325
TRA2A transformer 2 alpha homolog (Drosophila) -0.024748
RIOK3 RIO kinase 3 -0.0245309
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0244
ZMYND8 zinc finger, MYND-type containing 8 -0.0240836
VRK2 vaccinia related kinase 2 -0.0240493
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0239475
RLF rearranged L-myc fusion -0.0238951
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0238868
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0238175
NCOA7 nuclear receptor coactivator 7 -0.0234863
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0232961
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0229656
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0228875
PCNX1 pecanex 1 -0.0228677
WAC WW domain containing adaptor with coiled-coil -0.0224182
DLG1 discs, large homolog 1 (Drosophila) -0.0224086
KCTD9 potassium channel tetramerization domain containing 9 -0.0222395
RAD21 RAD21 homolog (S. pombe) -0.0222324
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0221779
FTL ferritin, light polypeptide -0.0221718
SBF2 SET binding factor 2 -0.0221211
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0220431
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0216409
NIPBL Nipped-B homolog (Drosophila) -0.0215572
CLINT1 clathrin interactor 1 -0.0213412
MIS18BP1 MIS18 binding protein 1 -0.021129
QKI QKI, KH domain containing, RNA binding -0.0209924
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0209267
KPNB1 karyopherin (importin) beta 1 -0.0208618
COL12A1 collagen, type XII, alpha 1 -0.0207786
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0206443
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0205893
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0205236
PSD3 pleckstrin and Sec7 domain containing 3 -0.0200941
GNAS GNAS complex locus -0.0200423
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.019922
ZNF292 zinc finger protein 292 -0.0198112
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0196722
TOP2B topoisomerase (DNA) II beta 180kDa -0.0196201
CTNNBL1 catenin, beta like 1 -0.0196078
CXCL5 chemokine (C-X-C motif) ligand 5 -0.0194615
HDLBP high density lipoprotein binding protein -0.0194548
BZW1 basic leucine zipper and W2 domains 1 -0.0193189
ABI1 abl-interactor 1 -0.0193069
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0191616
RNF145 ring finger protein 145 -0.0191603
NEK7 NIMA-related kinase 7 -0.0190336
GARS1 glycyl-tRNA synthetase 1 -0.0189671