| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ipatasertib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.21045 |
| TXNRD1 | thioredoxin reductase 1 | 0.146166 |
| VIM | vimentin | 0.13134 |
| RTN4 | reticulon 4 | 0.0799639 |
| SVIL | supervillin | 0.0772152 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0707287 |
| TNPO1 | transportin 1 | 0.067604 |
| FAM107B | family with sequence similarity 107, member B | 0.0672201 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0624592 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0621238 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0619352 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0602093 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0573213 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0566966 |
| ANXA2 | annexin A2 | 0.0561804 |
| LAMB1 | laminin, beta 1 | 0.0552357 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0521861 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0515091 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0509842 |
| TPD52 | tumor protein D52 | 0.050869 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0507934 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.050212 |
| TPM3 | tropomyosin 3 | 0.0493966 |
| JMJD1C | jumonji domain containing 1C | 0.0478766 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0474801 |
| YAP1 | Yes-associated protein 1 | 0.0473426 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0470224 |
| PLS3 | plastin 3 | 0.0468613 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0468558 |
| USP3 | ubiquitin specific peptidase 3 | 0.0465053 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0456931 |
| PDE8A | phosphodiesterase 8A | 0.0456244 |
| ASPH | aspartate beta-hydroxylase | 0.0449022 |
| ZFHX3 | zinc finger homeobox 3 | 0.0448667 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0448275 |
| RBM25 | RNA binding motif protein 25 | 0.0444891 |
| SIK3 | SIK family kinase 3 | 0.0440485 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.043812 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0427511 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.041813 |
| KIF5B | kinesin family member 5B | 0.0414914 |
| GLG1 | golgi glycoprotein 1 | 0.0410769 |
| HMGA1 | high mobility group AT-hook 1 | 0.0408401 |
| WDR43 | WD repeat domain 43 | 0.0406636 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0405208 |
| FGB | fibrinogen beta chain | 0.0399194 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0396036 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.038909 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0388508 |
| ZNF292 | zinc finger protein 292 | 0.0382872 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0380365 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0379477 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0378948 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.037463 |
| NTN4 | netrin 4 | 0.0372733 |
| MTDH | metadherin | 0.0367881 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0365566 |
| RPS6 | ribosomal protein S6 | 0.0365478 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0361647 |
| ENAH | enabled homolog (Drosophila) | 0.0353601 |
| MYOF | myoferlin | 0.0351495 |
| RNF145 | ring finger protein 145 | 0.0348834 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0346822 |
| DENND5B | DENN/MADD domain containing 5B | 0.0345642 |
| WAC | WW domain containing adaptor with coiled-coil | 0.034423 |
| ANXA5 | annexin A5 | 0.0336347 |
| MATR3 | matrin 3 | 0.0334305 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0333212 |
| DST | dystonin | 0.0332888 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0332837 |
| TPM4 | tropomyosin 4 | 0.0331684 |
| PTEN | phosphatase and tensin homolog | 0.0330967 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0324526 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0315768 |
| NEK7 | NIMA-related kinase 7 | 0.0314495 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0314461 |
| CHN1 | chimerin 1 | 0.0310789 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.030986 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0307821 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0302363 |
| ITGB5 | integrin, beta 5 | 0.0299723 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0297246 |
| RPS12 | ribosomal protein S12 | 0.0296446 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0295452 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0293714 |
| RUNX1 | runt-related transcription factor 1 | 0.0293041 |
| TMEM245 | transmembrane protein 245 | 0.028986 |
| XPO1 | exportin 1 | 0.0289657 |
| FNBP1L | formin binding protein 1-like | 0.0288209 |
| ENO1 | enolase 1, (alpha) | 0.0287759 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0284398 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0281171 |
| CD99 | CD99 molecule | 0.0280828 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.028067 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0278396 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0278326 |
| PKM | pyruvate kinase, muscle | 0.0276916 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0276857 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0276842 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0276804 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.198601 |
| TMSB10 | thymosin beta 10 | -0.154443 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.112095 |
| IER3 | immediate early response 3 | -0.0997638 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0960234 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0906771 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0901787 |
| KYNU | kynureninase | -0.0755728 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0661746 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0604624 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0597156 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0569057 |
| ACTG1 | actin gamma 1 | -0.0532081 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0494054 |
| IL6 | interleukin 6 | -0.0484415 |
| EGFR | epidermal growth factor receptor | -0.043814 |
| AHNAK | AHNAK nucleoprotein | -0.0429518 |
| IGF2 | insulin-like growth factor 2 | -0.0419991 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.041862 |
| EGR1 | early growth response 1 | -0.0413554 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0407259 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0394692 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0381434 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0376577 |
| VCL | vinculin | -0.0374998 |
| DENND4A | DENN/MADD domain containing 4A | -0.0371736 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0354825 |
| MCL1 | myeloid cell leukemia 1 | -0.0352336 |
| MORF4L2 | mortality factor 4 like 2 | -0.0349844 |
| ATG7 | autophagy related 7 | -0.0349231 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0347023 |
| INTS6 | integrator complex subunit 6 | -0.0333146 |
| RPS21 | ribosomal protein S21 | -0.0321812 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0310767 |
| USP34 | ubiquitin specific peptidase 34 | -0.0292913 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0284862 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.028257 |
| NLK | nemo-like kinase | -0.0278535 |
| GPATCH2L | G patch domain containing 2-like | -0.026985 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0265508 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0265296 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0262275 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0259172 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0257253 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -0.0256786 |
| COPA | coatomer protein complex, subunit alpha | -0.0256496 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0249827 |
| HDLBP | high density lipoprotein binding protein | -0.0249635 |
| SQSTM1 | sequestosome 1 | -0.024397 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.023996 |
| TPM1 | tropomyosin 1 (alpha) | -0.0235055 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0233235 |
| CMIP | c-Maf inducing protein | -0.0232468 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0231515 |
| MYO1E | myosin IE | -0.0228203 |
| H1-0 | H1.0 linker histone | -0.0226919 |
| NRG1 | neuregulin 1 | -0.0218569 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.02164 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0216086 |
| NABP1 | nucleic acid binding protein 1 | -0.0215193 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0213928 |
| NEK10 | NIMA-related kinase 10 | -0.0213359 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0213233 |
| RAD51B | RAD51 paralog B | -0.0202952 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0202589 |
| NUP98 | nucleoporin 98kDa | -0.020178 |
| TTC7B | tetratricopeptide repeat domain 7B | -0.0199137 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0198962 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0197146 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0196663 |
| AADAC | arylacetamide deacetylase | -0.019387 |
| ATF6 | activating transcription factor 6 | -0.019226 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0192203 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0190512 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0190356 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.019018 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0189239 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0189103 |
| CLDN1 | claudin 1 | -0.018886 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0188103 |
| PSEN1 | presenilin 1 | -0.01858 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0184321 |
| THBS1 | thrombospondin 1 | -0.0184042 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -0.0183324 |
| VMP1 | vacuole membrane protein 1 | -0.0182401 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0181513 |
| GLIS3 | GLIS family zinc finger 3 | -0.0180612 |
| NF1 | neurofibromin 1 | -0.0179963 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0179261 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0179166 |
| CYP20A1 | cytochrome P450, family 20, subfamily A, polypeptide 1 | -0.017888 |
| HLA-B | major histocompatibility complex, class I, B | -0.0178034 |
| MAP7 | microtubule-associated protein 7 | -0.0177745 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0177576 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0176932 |
| DENND1A | DENN/MADD domain containing 1A | -0.0176623 |
| RPL36AL | ribosomal protein L36a-like | -0.0176393 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.01757 |
| PMM2 | phosphomannomutase 2 | -0.0175403 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0175038 |
