| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ipatasertib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.23513 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.217635 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.156603 |
| RPS6 | ribosomal protein S6 | 0.0851072 |
| NDRG1 | N-myc downstream regulated 1 | 0.0843569 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0784526 |
| STC1 | stanniocalcin 1 | 0.0744779 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0701727 |
| TXNRD1 | thioredoxin reductase 1 | 0.0680336 |
| BPTF | bromodomain PHD finger transcription factor | 0.0668581 |
| RPL31 | ribosomal protein L31 | 0.0634318 |
| TMSB10 | thymosin beta 10 | 0.0633476 |
| ZNF292 | zinc finger protein 292 | 0.0628323 |
| MT2A | metallothionein 2A | 0.0604502 |
| VIM | vimentin | 0.060092 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0589196 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0580554 |
| RPL5 | ribosomal protein L5 | 0.0577728 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0564042 |
| PGK1 | phosphoglycerate kinase 1 | 0.0556053 |
| RPS3 | ribosomal protein S3 | 0.0550381 |
| HLA-B | major histocompatibility complex, class I, B | 0.0547556 |
| ASPH | aspartate beta-hydroxylase | 0.0531497 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0531152 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.052279 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0519738 |
| KRT17 | keratin 17, type I | 0.0514958 |
| RPS12 | ribosomal protein S12 | 0.0513798 |
| HMGA1 | high mobility group AT-hook 1 | 0.0510029 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0509088 |
| ATXN1 | ataxin 1 | 0.0507522 |
| RPLP1 | ribosomal protein, large, P1 | 0.0506212 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0492314 |
| FTL | ferritin, light polypeptide | 0.0490881 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0480341 |
| PKM | pyruvate kinase, muscle | 0.0472325 |
| PRKCA | protein kinase C, alpha | 0.0467612 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0463584 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0463162 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0460977 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0458739 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0456135 |
| MED13L | mediator complex subunit 13-like | 0.0448415 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0434816 |
| RPL19 | ribosomal protein L19 | 0.0431168 |
| SMYD3 | SET and MYND domain containing 3 | 0.0424578 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0420806 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0409666 |
| RPL12 | ribosomal protein L12 | 0.0407736 |
| PCBP2 | poly(rC) binding protein 2 | 0.0398278 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0396546 |
| RPL35A | ribosomal protein L35a | 0.0394048 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0392991 |
| RPS8 | ribosomal protein S8 | 0.039056 |
| RPS19 | ribosomal protein S19 | 0.0388845 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0388685 |
| NF1 | neurofibromin 1 | 0.0387996 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0384342 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0383969 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0383016 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0377876 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0373436 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0366109 |
| ACTN1 | actinin, alpha 1 | 0.0365658 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0356835 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0355826 |
| CUX1 | cut-like homeobox 1 | 0.0354142 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0347424 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0345502 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0341719 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.034059 |
| RPL28 | ribosomal protein L28 | 0.0339155 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0331256 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0330347 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0329134 |
| JMJD1C | jumonji domain containing 1C | 0.0324375 |
| RPL11 | ribosomal protein L11 | 0.0323953 |
| CANX | calnexin | 0.0323243 |
| GPC6 | glypican 6 | 0.0312782 |
| RAD51B | RAD51 paralog B | 0.0312328 |
| NCKAP1 | NCK-associated protein 1 | 0.031064 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0309421 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0307082 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0306864 |
| RPLP0 | ribosomal protein, large, P0 | 0.0306437 |
| CSTB | cystatin B (stefin B) | 0.030638 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.030288 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0302582 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0300332 |
| MYO1D | myosin ID | 0.0298844 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0298476 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0296713 |
| RPL30 | ribosomal protein L30 | 0.0295433 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0293392 |
| PRKCE | protein kinase C, epsilon | 0.0293123 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.029222 |
| FLNB | filamin B, beta | 0.0290507 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0290326 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0290295 |
| TNPO1 | transportin 1 | 0.0287896 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.197078 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.127192 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.100981 |
| LAMC2 | laminin, gamma 2 | -0.0925499 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0918498 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.085731 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0846564 |
| MYO1E | myosin IE | -0.079776 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.077593 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0691652 |
| SVIL | supervillin | -0.0679675 |
| FOXO1 | forkhead box O1 | -0.0669555 |
| CMIP | c-Maf inducing protein | -0.0629882 |
| LAMB3 | laminin, beta 3 | -0.0623158 |
| RESF1 | retroelement silencing factor 1 | -0.0607977 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0566926 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0551656 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0543171 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0538831 |
| MUC16 | mucin 16, cell surface associated | -0.053837 |
| SGMS2 | sphingomyelin synthase 2 | -0.0531259 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0529719 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0519947 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0516012 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0506605 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0505268 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.050378 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0480561 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0465023 |
| AFDN | afadin, adherens junction formation factor | -0.0464183 |
| ANXA2 | annexin A2 | -0.0457165 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0456354 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0455676 |
| PALLD | palladin, cytoskeletal associated protein | -0.0448425 |
| RBM47 | RNA binding motif protein 47 | -0.0446657 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0441699 |
| GLUL | glutamate-ammonia ligase | -0.0441614 |
| STEAP4 | STEAP family member 4 | -0.0439933 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0437445 |
| OCLN | occludin | -0.043598 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0435021 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0428258 |
| MYO10 | myosin X | -0.0415857 |
| ATOSA | atos homolog A | -0.0413492 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0413446 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0412594 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0411912 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0407324 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0403263 |
| TJP2 | tight junction protein 2 | -0.0402474 |
| TC2N | tandem C2 domains, nuclear | -0.0401698 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0399861 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.039015 |
| OXSR1 | oxidative stress responsive 1 | -0.0385897 |
| YME1L1 | YME1-like 1 ATPase | -0.0384938 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0384044 |
| USP3 | ubiquitin specific peptidase 3 | -0.0383457 |
| FBXO34 | F-box protein 34 | -0.03801 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0378426 |
| ANO6 | anoctamin 6 | -0.0376343 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0372717 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0364634 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.0357597 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0356038 |
| MYO6 | myosin VI | -0.0355592 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0347948 |
| SETX | senataxin | -0.0347157 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0346583 |
| EZR | ezrin | -0.0346128 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0345408 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0342304 |
| MXD1 | MAX dimerization protein 1 | -0.0340632 |
| JMY | junction mediating and regulatory protein, p53 cofactor | -0.0338319 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0336181 |
| ZBTB43 | zinc finger and BTB domain containing 43 | -0.0335784 |
| PHF3 | PHD finger protein 3 | -0.03335 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0333046 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | -0.0331711 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0331322 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0330153 |
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | -0.0329356 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0327963 |
| WDR26 | WD repeat domain 26 | -0.0326846 |
| SETD2 | SET domain containing 2 | -0.0326085 |
| DSG2 | desmoglein 2 | -0.0323744 |
| MEF2A | myocyte enhancer factor 2A | -0.0322804 |
| YBX3 | Y box binding protein 3 | -0.0321052 |
| GOLGA4 | golgin A4 | -0.0319788 |
| VCL | vinculin | -0.0319526 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0318797 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0316469 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0313019 |
| SLK | STE20-like kinase | -0.0312835 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0307938 |
| GLG1 | golgi glycoprotein 1 | -0.030714 |
| JUP | junction plakoglobin | -0.0303864 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0302398 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0302157 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.030128 |
| KLC1 | kinesin light chain 1 | -0.0297668 |
