| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ipatasertib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.0630483 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0589222 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0504046 |
| DENND5B | DENN/MADD domain containing 5B | 0.0496331 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0488568 |
| XPO1 | exportin 1 | 0.0478036 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0474931 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0467875 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0463283 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.046258 |
| GRAMD1B | GRAM domain containing 1B | 0.0457521 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0454814 |
| MED13L | mediator complex subunit 13-like | 0.0447405 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0443793 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0441188 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0436078 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.042702 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0415312 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0364019 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0363823 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0359117 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0358065 |
| GPHN | gephyrin | 0.0349981 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0347046 |
| RPL5 | ribosomal protein L5 | 0.0340341 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0329228 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0324846 |
| ZNF638 | zinc finger protein 638 | 0.0318245 |
| EXOC4 | exocyst complex component 4 | 0.0317819 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0315065 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0313692 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0307988 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0300612 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0296469 |
| SMYD3 | SET and MYND domain containing 3 | 0.0295521 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0295273 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0294424 |
| JMJD1C | jumonji domain containing 1C | 0.0293359 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0292467 |
| DST | dystonin | 0.029012 |
| RPS3 | ribosomal protein S3 | 0.0286714 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0284401 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0283706 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0280444 |
| RAD51B | RAD51 paralog B | 0.0280108 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0278175 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0277222 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0276751 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0276661 |
| XPOT | exportin, tRNA | 0.0275482 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0275274 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0274682 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0268695 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0268475 |
| RAB10 | RAB10, member RAS oncogene family | 0.0268153 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0267442 |
| SMAD3 | SMAD family member 3 | 0.0266976 |
| RNF145 | ring finger protein 145 | 0.026664 |
| EXOC6B | exocyst complex component 6B | 0.0264872 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0264553 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0264314 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0258895 |
| SSH2 | slingshot protein phosphatase 2 | 0.0254678 |
| NF1 | neurofibromin 1 | 0.0251829 |
| TMEM41B | transmembrane protein 41B | 0.0249613 |
| PCBP2 | poly(rC) binding protein 2 | 0.0247897 |
| USP34 | ubiquitin specific peptidase 34 | 0.0247533 |
| RPS12 | ribosomal protein S12 | 0.0247452 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0247399 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0243771 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0240167 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0239565 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0239347 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0236911 |
| CDK13 | cyclin-dependent kinase 13 | 0.0236773 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0235702 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0233694 |
| GPR39 | G protein-coupled receptor 39 | 0.0233037 |
| SP3 | Sp3 transcription factor | 0.0232599 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0232475 |
| ANO6 | anoctamin 6 | 0.0230633 |
| IPO7 | importin 7 | 0.0230352 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0229755 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0228565 |
| TNPO1 | transportin 1 | 0.0228332 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0227966 |
| AGO3 | argonaute RISC catalytic component 3 | 0.022793 |
| YAP1 | Yes-associated protein 1 | 0.0226149 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0224205 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0222623 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0220024 |
| ATXN2 | ataxin 2 | 0.0219752 |
| TPM3 | tropomyosin 3 | 0.0219671 |
| TRIM33 | tripartite motif containing 33 | 0.0216889 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0215942 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0215918 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0214609 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0214519 |
| ADIPOR2 | adiponectin receptor 2 | 0.021355 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0213275 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.301389 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.218307 |
| TMSB10 | thymosin beta 10 | -0.107185 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0625254 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0622623 |
| PTMA | prothymosin, alpha | -0.0591351 |
| EGR1 | early growth response 1 | -0.0548519 |
| YBX3 | Y box binding protein 3 | -0.051257 |
| HLA-B | major histocompatibility complex, class I, B | -0.047568 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0455288 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0454473 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0453107 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0441746 |
| ACTG1 | actin gamma 1 | -0.0384776 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0383054 |
| RPL35A | ribosomal protein L35a | -0.0376174 |
| MCL1 | myeloid cell leukemia 1 | -0.0366756 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0343983 |
| OSMR | oncostatin M receptor | -0.0340063 |
| VIM | vimentin | -0.0334679 |
| IER3 | immediate early response 3 | -0.0320959 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0313463 |
| RNF213 | ring finger protein 213 | -0.0293038 |
| TPM4 | tropomyosin 4 | -0.028845 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0282754 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0275174 |
| AFF3 | AF4/FMR2 family, member 3 | -0.027315 |
| TPM2 | tropomyosin 2 (beta) | -0.027174 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0261465 |
| STC1 | stanniocalcin 1 | -0.0246329 |
| RYR3 | ryanodine receptor 3 | -0.0241533 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0240044 |
| NCOA7 | nuclear receptor coactivator 7 | -0.02391 |
| POTEF | POTE ankyrin domain family, member F | -0.0236289 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0234851 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0224618 |
| FTL | ferritin, light polypeptide | -0.021843 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0212046 |
| PLSCR1 | phospholipid scramblase 1 | -0.0209605 |
| MT2A | metallothionein 2A | -0.0208072 |
| RPS19 | ribosomal protein S19 | -0.0202611 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.020074 |
| RIGI | RNA sensor RIG-I | -0.0198108 |
| TCIM | transcriptional and immune response regulator | -0.01967 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0196484 |
| RPL34 | ribosomal protein L34 | -0.0191487 |
| H1-0 | H1.0 linker histone | -0.0189494 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0188684 |
| PMP22 | peripheral myelin protein 22 | -0.0188164 |
| PFN1 | profilin 1 | -0.0187209 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0185349 |
| JUN | jun proto-oncogene | -0.0183949 |
| RPL8 | ribosomal protein L8 | -0.0182588 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0182137 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0170836 |
| HLA-E | major histocompatibility complex, class I, E | -0.0168159 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0162943 |
| HLA-C | major histocompatibility complex, class I, C | -0.0161519 |
| MX1 | MX dynamin-like GTPase 1 | -0.0159349 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0158972 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0158741 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0158115 |
| S100A11 | S100 calcium binding protein A11 | -0.0154757 |
| FMN1 | formin 1 | -0.0154076 |
| NABP1 | nucleic acid binding protein 1 | -0.0151723 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0151102 |
| GNAS | GNAS complex locus | -0.0148225 |
| PTMS | parathymosin | -0.0147285 |
| COL5A2 | collagen, type V, alpha 2 | -0.0142947 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0141072 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.0139502 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0139346 |
| CLDN1 | claudin 1 | -0.0135757 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0132802 |
| SEC61G | Sec61 gamma subunit | -0.013279 |
| KRT18 | keratin 18, type I | -0.0132366 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.013079 |
| ANGPTL4 | angiopoietin-like 4 | -0.0129167 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0128558 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0127461 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0126492 |
| RPS14 | ribosomal protein S14 | -0.012522 |
| LDHA | lactate dehydrogenase A | -0.012465 |
| DSPP | dentin sialophosphoprotein | -0.0123801 |
| MT1X | metallothionein 1X | -0.0123006 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0122583 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0121152 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0120336 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0120121 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0119981 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0118453 |
| SLFN5 | schlafen family member 5 | -0.0118445 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.01181 |
| UBB | ubiquitin B | -0.0117266 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0114848 |
| IGF2 | insulin-like growth factor 2 | -0.0114642 |
| RPL19 | ribosomal protein L19 | -0.0114218 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.011382 |
| RPL23 | ribosomal protein L23 | -0.0111884 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0110468 |
