| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ipatasertib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.149531 |
| NDRG1 | N-myc downstream regulated 1 | 0.106434 |
| FTL | ferritin, light polypeptide | 0.0851028 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0775026 |
| HMGA1 | high mobility group AT-hook 1 | 0.0641789 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0640285 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0618098 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0574914 |
| ERBIN | erbb2 interacting protein | 0.0512961 |
| RBM25 | RNA binding motif protein 25 | 0.0505723 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0484906 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0472995 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.045772 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0452375 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0439965 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0431533 |
| RUNX1 | runt-related transcription factor 1 | 0.0428037 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0420407 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0409672 |
| ANXA5 | annexin A5 | 0.0408838 |
| ARRDC3 | arrestin domain containing 3 | 0.039068 |
| TXNRD1 | thioredoxin reductase 1 | 0.0370761 |
| TXNIP | thioredoxin interacting protein | 0.0367992 |
| FHIT | fragile histidine triad | 0.0364438 |
| SGMS2 | sphingomyelin synthase 2 | 0.0347842 |
| ZNF292 | zinc finger protein 292 | 0.0337449 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0327713 |
| RPL5 | ribosomal protein L5 | 0.032289 |
| SETD5 | SET domain containing 5 | 0.0321107 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0317263 |
| PCBP2 | poly(rC) binding protein 2 | 0.0316942 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0315668 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0275557 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0272025 |
| TJP1 | tight junction protein 1 | 0.0270381 |
| RNF145 | ring finger protein 145 | 0.0269578 |
| RPS12 | ribosomal protein S12 | 0.0263039 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0261452 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0261158 |
| GRAMD2B | GRAM domain containing 2B | 0.0258464 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0258343 |
| CNKSR3 | CNKSR family member 3 | 0.0253849 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0248433 |
| ANXA2 | annexin A2 | 0.0246588 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.024478 |
| SCFD1 | sec1 family domain containing 1 | 0.0242306 |
| RPLP0 | ribosomal protein, large, P0 | 0.0238397 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0235455 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0234062 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0230584 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0229611 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0228325 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0226489 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0225921 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0225182 |
| PTK2 | protein tyrosine kinase 2 | 0.0224367 |
| SNX9 | sorting nexin 9 | 0.0222458 |
| YAP1 | Yes-associated protein 1 | 0.0221053 |
| BCL2L1 | BCL2-like 1 | 0.0220813 |
| MYO10 | myosin X | 0.0220032 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0218529 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0217374 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0215558 |
| DSTN | destrin (actin depolymerizing factor) | 0.0209612 |
| RYBP | RING1 and YY1 binding protein | 0.02089 |
| RPL30 | ribosomal protein L30 | 0.0207497 |
| PCDH7 | protocadherin 7 | 0.0203546 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0203461 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0201352 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0201151 |
| BPTF | bromodomain PHD finger transcription factor | 0.0198334 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0197783 |
| ZNF148 | zinc finger protein 148 | 0.0196668 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0194076 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0193445 |
| STK24 | serine/threonine kinase 24 | 0.0193239 |
| MATR3 | matrin 3 | 0.0191075 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.0190017 |
| IL6ST | interleukin 6 signal transducer | 0.0189976 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0189166 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0188708 |
| VGLL3 | vestigial-like family member 3 | 0.0188191 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0186253 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0185221 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0184564 |
| GPHN | gephyrin | 0.0183533 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0183499 |
| TJP2 | tight junction protein 2 | 0.0183392 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0182626 |
| RPS2 | ribosomal protein S2 | 0.0182624 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.0182337 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0182189 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.018204 |
| FOXJ3 | forkhead box J3 | 0.017843 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0178332 |
| ASPH | aspartate beta-hydroxylase | 0.0176431 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0176162 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0175469 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0175213 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0174018 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.262615 |
| PTMA | prothymosin, alpha | -0.21199 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.203757 |
| FN1 | fibronectin 1 | -0.196699 |
| TMSB10 | thymosin beta 10 | -0.1572 |
| ACTG1 | actin gamma 1 | -0.149401 |
| CANX | calnexin | -0.110381 |
| LAMB3 | laminin, beta 3 | -0.0958165 |
| FBXO32 | F-box protein 32 | -0.0901841 |
| AHNAK | AHNAK nucleoprotein | -0.0876814 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0851886 |
| GRB10 | growth factor receptor-bound protein 10 | -0.08104 |
| TMSB4X | thymosin beta 4, X-linked | -0.0768627 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0719274 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.071355 |
| LAMC2 | laminin, gamma 2 | -0.0709791 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0648241 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0597095 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0579371 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0567501 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0563893 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0555789 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0533872 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0530933 |
| RNF213 | ring finger protein 213 | -0.0506942 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.048843 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0480235 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0477625 |
| SQSTM1 | sequestosome 1 | -0.0462759 |
| LMO7 | LIM domain 7 | -0.0454421 |
| MX1 | MX dynamin-like GTPase 1 | -0.0447732 |
| TPM4 | tropomyosin 4 | -0.0443381 |
| PGK1 | phosphoglycerate kinase 1 | -0.0442807 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0437239 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0426081 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0424983 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0415921 |
| PLEC | plectin | -0.0414479 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0397643 |
| MSI2 | musashi RNA-binding protein 2 | -0.0392062 |
| CALR | calreticulin | -0.0383276 |
| G0S2 | G0/G1 switch 2 | -0.0381962 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0379019 |
| H1-0 | H1.0 linker histone | -0.0377142 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0376368 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0375914 |
| ADAR | adenosine deaminase, RNA-specific | -0.037396 |
| SP100 | SP100 nuclear antigen | -0.0372595 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0367998 |
| HLA-E | major histocompatibility complex, class I, E | -0.0357814 |
| RAI14 | retinoic acid induced 14 | -0.0357269 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0351426 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0349148 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0344613 |
| RIGI | RNA sensor RIG-I | -0.0340238 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0338721 |
| KRT7 | keratin 7, type II | -0.0337337 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0335825 |
| HLA-B | major histocompatibility complex, class I, B | -0.0331912 |
| HLA-A | major histocompatibility complex, class I, A | -0.0327055 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0326107 |
| MAP1B | microtubule-associated protein 1B | -0.0325213 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.032491 |
| PLSCR1 | phospholipid scramblase 1 | -0.0324662 |
| RPS19 | ribosomal protein S19 | -0.0324476 |
| CD2AP | CD2-associated protein | -0.0318776 |
| HDLBP | high density lipoprotein binding protein | -0.031695 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0300541 |
| KRT18 | keratin 18, type I | -0.0298944 |
| MX2 | MX dynamin-like GTPase 2 | -0.029783 |
| HMGB2 | high mobility group box 2 | -0.0295739 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.029208 |
| S100A6 | S100 calcium binding protein A6 | -0.0291697 |
| DUSP10 | dual specificity phosphatase 10 | -0.028859 |
| GNAS | GNAS complex locus | -0.0285122 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0281558 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0280095 |
| CAB39 | calcium binding protein 39 | -0.0275842 |
| ARF1 | ADP-ribosylation factor 1 | -0.0272375 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0270894 |
| RPL34 | ribosomal protein L34 | -0.0270422 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0270217 |
| RPL32 | ribosomal protein L32 | -0.0270196 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0260168 |
| STK17A | serine/threonine kinase 17a | -0.0258762 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0257478 |
| LMNA | lamin A/C | -0.0256794 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0255107 |
| S100A10 | S100 calcium binding protein A10 | -0.0252914 |
| MYO1E | myosin IE | -0.0244769 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.024366 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0242615 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0242526 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0238827 |
| RPLP1 | ribosomal protein, large, P1 | -0.0238677 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0237843 |
| PLAU | plasminogen activator, urokinase | -0.0235636 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0233368 |
| MAP4 | microtubule-associated protein 4 | -0.0232574 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0230443 |
