Ipatasertib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.182885
PSD3 pleckstrin and Sec7 domain containing 3 0.13263
ASPH aspartate beta-hydroxylase 0.112618
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.109789
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.106358
GRAMD1B GRAM domain containing 1B 0.0899273
PDE10A phosphodiesterase 10A 0.0824038
CDH13 cadherin 13 0.0702089
RPS6 ribosomal protein S6 0.0622346
ZSWIM6 zinc finger, SWIM-type containing 6 0.0621748
TPT1 tumor protein, translationally-controlled 1 0.0610244
RPS12 ribosomal protein S12 0.0592949
RPL31 ribosomal protein L31 0.0589645
NALF1 NALCN channel auxiliary factor 1 0.0558915
FMNL2 formin-like 2 0.0537252
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.050726
PTPRM protein tyrosine phosphatase, receptor type, M 0.0506126
RPLP1 ribosomal protein, large, P1 0.0503209
RPL37A ribosomal protein L37a 0.0501729
NAP1L1 nucleosome assembly protein 1-like 1 0.0495622
DOCK4 dedicator of cytokinesis 4 0.0494269
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0491181
RPS8 ribosomal protein S8 0.0488529
PRKN parkin RBR E3 ubiquitin protein ligase 0.0468214
ANXA2 annexin A2 0.0466184
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0454892
RPLP0 ribosomal protein, large, P0 0.0454011
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0426766
TXNRD1 thioredoxin reductase 1 0.0415229
NHSL1 NHS-like 1 0.0411636
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0410821
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0410499
MAML3 mastermind-like 3 (Drosophila) 0.0402349
TNPO1 transportin 1 0.0393132
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0374919
RPL37 ribosomal protein L37 0.037475
RPL26 ribosomal protein L26 0.0373121
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0371245
CAPN2 calpain 2, (m/II) large subunit 0.036604
DOCK5 dedicator of cytokinesis 5 0.0362955
FOXK1 forkhead box K1 0.0358873
RPS24 ribosomal protein S24 0.0351995
RPL9 ribosomal protein L9 0.0351442
RPL12 ribosomal protein L12 0.0344537
PKM pyruvate kinase, muscle 0.033981
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0336611
VCL vinculin 0.0332287
MCTP1 multiple C2 domains, transmembrane 1 0.033182
HSPA8 heat shock 70kDa protein 8 0.0331647
RPL11 ribosomal protein L11 0.0327893
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0326744
RAB10 RAB10, member RAS oncogene family 0.032293
RAD51B RAD51 paralog B 0.0322682
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0319494
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0312541
MACF1 microtubule-actin crosslinking factor 1 0.0312374
DGKD diacylglycerol kinase, delta 130kDa 0.0311137
RPL5 ribosomal protein L5 0.0311098
RPS27A ribosomal protein S27a 0.0308972
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0304339
FTL ferritin, light polypeptide 0.0298696
RPL13A ribosomal protein L13a 0.0293455
FBXL17 F-box and leucine-rich repeat protein 17 0.0291
RPS2 ribosomal protein S2 0.02898
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0287895
RPS3 ribosomal protein S3 0.0287544
RPL39 ribosomal protein L39 0.0283084
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0280854
BZW1 basic leucine zipper and W2 domains 1 0.0278771
AKAP13 A kinase (PRKA) anchor protein 13 0.027808
NT5C2 5'-nucleotidase, cytosolic II 0.0277995
INTS6 integrator complex subunit 6 0.0276067
POTEF POTE ankyrin domain family, member F 0.0273369
RPS17 ribosomal protein S17 0.0273278
LDHA lactate dehydrogenase A 0.0273075
SMAD2 SMAD family member 2 0.027134
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.026866
RPL23 ribosomal protein L23 0.0267757
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0264027
EPHA4 EPH receptor A4 0.0263027
RPL35A ribosomal protein L35a 0.0262733
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0260761
ACTG1 actin gamma 1 0.0260435
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.025555
ANKRD17 ankyrin repeat domain 17 0.0254789
RACK1 receptor for activated C kinase 1 0.0254265
RPS25 ribosomal protein S25 0.0254224
WWTR1 WW domain containing transcription regulator 1 0.0252769
PDLIM5 PDZ and LIM domain 5 0.0252144
B2M beta-2-microglobulin 0.0251634
ENO1 enolase 1, (alpha) 0.0249528
RPL27 ribosomal protein L27 0.0248624
RPL7A ribosomal protein L7a 0.0247709
SLF1 SMC5-SMC6 complex localization factor 1 0.0246141
TUSC3 tumor suppressor candidate 3 0.0245431
RPL19 ribosomal protein L19 0.0242901
NPAS2 neuronal PAS domain protein 2 0.0240496
NFE2L2 nuclear factor, erythroid 2-like 2 0.024043
EEF2 eukaryotic translation elongation factor 2 0.0239867
MAP7 microtubule-associated protein 7 0.023923

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.285052
IGFBP3 insulin-like growth factor binding protein 3 -0.0788213
NAMPT nicotinamide phosphoribosyltransferase -0.0726112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0725218
COL5A2 collagen, type V, alpha 2 -0.070875
LIMCH1 LIM and calponin homology domains 1 -0.0669777
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0668721
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0654641
EFNA5 ephrin-A5 -0.0589129
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0455397
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0422757
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0415123
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0408444
IL6 interleukin 6 -0.0408064
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0401888
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0392946
TMSB10 thymosin beta 10 -0.0389749
TMX4 thioredoxin-related transmembrane protein 4 -0.0373159
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0355095
FNDC3B fibronectin type III domain containing 3B -0.0345254
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0343222
DST dystonin -0.0340747
SAMD4A sterile alpha motif domain containing 4A -0.0335342
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0334558
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0331987
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0325856
CANX calnexin -0.032161
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0316832
INHBA inhibin, beta A -0.0305342
PBX1 pre-B-cell leukemia homeobox 1 -0.0284715
TGFBI transforming growth factor, beta-induced, 68kDa -0.0282615
GDA guanine deaminase -0.0270307
PM20D1 peptidase M20 domain containing 1 -0.0269024
COL8A1 collagen, type VIII, alpha 1 -0.0268763
ZEB2 zinc finger E-box binding homeobox 2 -0.0263551
DNER delta/notch-like EGF repeat containing -0.0260225
BASP1 brain abundant, membrane attached signal protein 1 -0.0258779
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0257867
STC1 stanniocalcin 1 -0.0255393
COL4A6 collagen, type IV, alpha 6 -0.0252328
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0249815
SLC16A6 solute carrier family 16, member 6 -0.023321
TBXT T-box transcription factor T -0.0226686
EGR1 early growth response 1 -0.0220472
MCL1 myeloid cell leukemia 1 -0.0219849
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0216096
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0211482
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.021124
ELL2 elongation factor, RNA polymerase II, 2 -0.0210345
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.020583
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0203734
PTMA prothymosin, alpha -0.0198019
DPYD dihydropyrimidine dehydrogenase -0.0197958
S100A6 S100 calcium binding protein A6 -0.0193387
STEAP1B STEAP family member 1B -0.0184787
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0182172
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0181669
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.0181104
OSMR oncostatin M receptor -0.0179822
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0178753
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.017588
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0172085
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0161876
ITPRID2 ITPR interacting domain containing 2 -0.0160324
MAML2 mastermind-like 2 (Drosophila) -0.0158058
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0157579
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0157154
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0155554
FNDC3A fibronectin type III domain containing 3A -0.0154248
MYPN myopalladin -0.0151039
CALR calreticulin -0.0150125
WARS1 tryptophanyl-tRNA synthetase 1 -0.0149047
TENM3 teneurin transmembrane protein 3 -0.0148843
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.014873
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0146925
P3H2 prolyl 3-hydroxylase 2 -0.0146155
P4HB prolyl 4-hydroxylase, beta polypeptide -0.014486
ENO2 enolase 2 (gamma, neuronal) -0.0144325
STC2 stanniocalcin 2 -0.0144244
PRKCSH protein kinase C substrate 80K-H -0.0143777
NGLY1 N-glycanase 1 -0.0141585
ESM1 endothelial cell-specific molecule 1 -0.0141091
NBEAL1 neurobeachin-like 1 -0.0140391
MFF mitochondrial fission factor -0.0140176
MARCHF1 membrane associated ring-CH-type finger 1 -0.0138417
SLC38A2 solute carrier family 38, member 2 -0.0138033
ZMYND8 zinc finger, MYND-type containing 8 -0.0137478
SOX4 SRY (sex determining region Y)-box 4 -0.0137301
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0135851
TFPI2 tissue factor pathway inhibitor 2 -0.0135066
RAI1 retinoic acid induced 1 -0.0134535
PHF21A PHD finger protein 21A -0.013439
PDE1A phosphodiesterase 1A, calmodulin-dependent -0.0133062
SOX6 SRY (sex determining region Y)-box 6 -0.0132918
NCAM2 neural cell adhesion molecule 2 -0.0129656
HDLBP high density lipoprotein binding protein -0.012911
BMERB1 bMERB domain containing 1 -0.0128777
IER3 immediate early response 3 -0.0125675
JUN jun proto-oncogene -0.012311
CEMIP cell migration inducing protein, hyaluronan binding -0.0122483