Ipatasertib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

94 genes differentially expressed following the Ipatasertib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.301894
ASPH aspartate beta-hydroxylase 0.224536
LPP LIM domain containing preferred translocation partner in lipoma 0.164094
PRELID2 PRELI domain containing 2 0.1537
ATXN1 ataxin 1 0.129467
SBF2 SET binding factor 2 0.1254
PKM pyruvate kinase, muscle 0.124279
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.123245
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.105953
USP34 ubiquitin specific peptidase 34 0.105857
PABPC1 poly(A) binding protein, cytoplasmic 1 0.102625
DSCAM Down syndrome cell adhesion molecule 0.0800573
RPS12 ribosomal protein S12 0.0746524
LDHA lactate dehydrogenase A 0.0736658
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0641148
SMYD3 SET and MYND domain containing 3 0.0601575
EXT1 exostosin glycosyltransferase 1 0.0586057
RPS8 ribosomal protein S8 0.0554286
FNDC3B fibronectin type III domain containing 3B 0.0531993
MYO1E myosin IE 0.0520064
PTK2 protein tyrosine kinase 2 0.0474713
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0355662
PDE10A phosphodiesterase 10A 0.0320915
CD44 CD44 molecule (Indian blood group) 0.0317352
CDH13 cadherin 13 0.0315695
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0312853
VIM vimentin 0.0274361
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0248456
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0246224
PRKCA protein kinase C, alpha 0.0233636
IGFBP3 insulin-like growth factor binding protein 3 0.0213199
TPT1 tumor protein, translationally-controlled 1 0.0203123
RPLP1 ribosomal protein, large, P1 0.0175392
RPS6 ribosomal protein S6 0.0166182
ACTG1 actin gamma 1 0.0143734
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0106433
RPS3 ribosomal protein S3 0.00882557
FN1 fibronectin 1 0.00791405
JMJD1C jumonji domain containing 1C 0.00746094
RPLP2 ribosomal protein, large, P2 0.00630582
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00324373
FTL ferritin, light polypeptide 0.00140475
PSD3 pleckstrin and Sec7 domain containing 3 8.32023E-4
DOCK4 dedicator of cytokinesis 4 4.62886E-4

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.189514
FNDC3A fibronectin type III domain containing 3A -0.136204
CXCL8 chemokine (C-X-C motif) ligand 8 -0.122038
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.115039
HMGA2 high mobility group AT-hook 2 -0.110536
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.107145
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.106279
RIGI RNA sensor RIG-I -0.101406
EGFR epidermal growth factor receptor -0.101089
BBX bobby sox homolog (Drosophila) -0.09778
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0964987
THSD4 thrombospondin, type I, domain containing 4 -0.086238
PARD3 par-3 family cell polarity regulator -0.0860471
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.082018
SLTM SAFB-like, transcription modulator -0.0793158
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0772699
AOPEP aminopeptidase O (putative) -0.0743684
SAMD4A sterile alpha motif domain containing 4A -0.0736795
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0734174
PDLIM5 PDZ and LIM domain 5 -0.0706398
TXNRD1 thioredoxin reductase 1 -0.0663491
CADM2 cell adhesion molecule 2 -0.0642464
PTMA prothymosin, alpha -0.0632589
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0529509
KMT2C lysine (K)-specific methyltransferase 2C -0.0526493
SETD5 SET domain containing 5 -0.0524316
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0522707
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0479675
STC1 stanniocalcin 1 -0.0419493
TCF12 transcription factor 12 -0.0395706
APP amyloid beta (A4) precursor protein -0.0376609
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0347781
HLA-B major histocompatibility complex, class I, B -0.0331193
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0327914
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0311636
SRPK2 SRSF protein kinase 2 -0.0301384
NDRG1 N-myc downstream regulated 1 -0.0271918
PRRC2C proline-rich coiled-coil 2C -0.0265771
RPS16 ribosomal protein S16 -0.0261485
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0256609
EIF1 eukaryotic translation initiation factor 1 -0.0141116
MT2A metallothionein 2A -0.0125489
TMSB10 thymosin beta 10 -0.0106335
MYO6 myosin VI -0.00824533
IGF2 insulin-like growth factor 2 -0.00665458
RPL37A ribosomal protein L37a -0.0060194
GRB10 growth factor receptor-bound protein 10 -0.00319907
TPM4 tropomyosin 4 -0.00284801
TRIO trio Rho guanine nucleotide exchange factor -0.00261698
AHNAK AHNAK nucleoprotein -0.00136078