| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ipatasertib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ipatasertib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.155079 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.116679 |
| FOXP2 | forkhead box P2 | 0.110095 |
| COL11A1 | collagen, type XI, alpha 1 | 0.0979924 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0817066 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0748679 |
| RPS12 | ribosomal protein S12 | 0.0738871 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.073371 |
| RPS16 | ribosomal protein S16 | 0.0708801 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0649429 |
| RPS8 | ribosomal protein S8 | 0.0642855 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0634194 |
| IGF2 | insulin-like growth factor 2 | 0.0626038 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0625301 |
| RPL5 | ribosomal protein L5 | 0.0615456 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0595832 |
| CDH19 | cadherin 19, type 2 | 0.0594246 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0591565 |
| DOCK5 | dedicator of cytokinesis 5 | 0.058012 |
| PEG10 | paternally expressed 10 | 0.0577781 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0575375 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0574806 |
| ACTG1 | actin gamma 1 | 0.0573143 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.056865 |
| PRTG | protogenin | 0.0566648 |
| MEIS2 | Meis homeobox 2 | 0.0555789 |
| RPS6 | ribosomal protein S6 | 0.0544874 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0541296 |
| ZNF292 | zinc finger protein 292 | 0.0538602 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0526414 |
| RPS3 | ribosomal protein S3 | 0.0499454 |
| MED12L | mediator complex subunit 12-like | 0.0497043 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0492363 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0487862 |
| JMJD1C | jumonji domain containing 1C | 0.0481715 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.047768 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.047518 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0460055 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0458495 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0444256 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0432016 |
| HMGA2 | high mobility group AT-hook 2 | 0.0431329 |
| ENAH | enabled homolog (Drosophila) | 0.0426427 |
| XPO1 | exportin 1 | 0.0423624 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0422345 |
| TOX | thymocyte selection-associated high mobility group box | 0.0407089 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0405523 |
| PUM1 | pumilio RNA-binding family member 1 | 0.040268 |
| VIM | vimentin | 0.0402316 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0398499 |
| SNX6 | sorting nexin 6 | 0.0396024 |
| RPLP0 | ribosomal protein, large, P0 | 0.0395388 |
| RPL37 | ribosomal protein L37 | 0.0394066 |
| LRRC4C | leucine rich repeat containing 4C | 0.0390211 |
| RPL31 | ribosomal protein L31 | 0.0389943 |
| NFIA | nuclear factor I/A | 0.0382653 |
| DACH1 | dachshund family transcription factor 1 | 0.0378134 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0377754 |
| TENM3 | teneurin transmembrane protein 3 | 0.0377613 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0376699 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0376552 |
| SIK2 | salt-inducible kinase 2 | 0.037441 |
| POTEF | POTE ankyrin domain family, member F | 0.0373232 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0370723 |
| MED13L | mediator complex subunit 13-like | 0.0368128 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0367381 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0366862 |
| SRPK2 | SRSF protein kinase 2 | 0.0365627 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0364923 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0360841 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0354301 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0350584 |
| RBM20 | RNA binding motif protein 20 | 0.0348418 |
| FIGN | fidgetin | 0.0348208 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.034595 |
| NBEAL1 | neurobeachin-like 1 | 0.0342946 |
| GNAS | GNAS complex locus | 0.0342179 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0338868 |
| RPL30 | ribosomal protein L30 | 0.0338851 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0338664 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0338583 |
| FOXO1 | forkhead box O1 | 0.0337173 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0335061 |
| RPL26 | ribosomal protein L26 | 0.033387 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0333699 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0333561 |
| HDAC9 | histone deacetylase 9 | 0.0333492 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0331168 |
| FBXO11 | F-box protein 11 | 0.0330535 |
| LDHA | lactate dehydrogenase A | 0.0329581 |
| MTF2 | metal response element binding transcription factor 2 | 0.0328814 |
| DMD | dystrophin | 0.0327988 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0326601 |
| USP25 | ubiquitin specific peptidase 25 | 0.0325963 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0325816 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.032537 |
| RPS13 | ribosomal protein S13 | 0.0323498 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0323097 |
| CDK13 | cyclin-dependent kinase 13 | 0.0319792 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0317252 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | -0.0381161 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0371999 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0339329 |
| AHNAK | AHNAK nucleoprotein | -0.0312053 |
| NEBL | nebulette | -0.0283854 |
| THBS1 | thrombospondin 1 | -0.0276098 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0266147 |
| SQSTM1 | sequestosome 1 | -0.0252156 |
| H1-0 | H1.0 linker histone | -0.0248162 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0221181 |
| COL5A2 | collagen, type V, alpha 2 | -0.0209905 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0206107 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0204984 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0201963 |
| NRG1 | neuregulin 1 | -0.0193493 |
| TMSB4X | thymosin beta 4, X-linked | -0.019286 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.018944 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0188884 |
| RAI1 | retinoic acid induced 1 | -0.0187284 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0184687 |
| MTCL1 | microtubule crosslinking factor 1 | -0.018435 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0183415 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0182651 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0181277 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0172634 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0172433 |
| TMSB10 | thymosin beta 10 | -0.0169554 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0167846 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0165219 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0162781 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | -0.0162301 |
| ZNF607 | zinc finger protein 607 | -0.016221 |
| FILIP1 | filamin A interacting protein 1 | -0.0161514 |
| SAFB2 | scaffold attachment factor B2 | -0.0159298 |
| PLEKHG4B | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | -0.0158889 |
| EXOC1 | exocyst complex component 1 | -0.0158618 |
| TNS3 | tensin 3 | -0.0156474 |
| MOB1A | MOB kinase activator 1A | -0.0152116 |
| SLC44A5 | solute carrier family 44, member 5 | -0.0152107 |
| SRSF7 | serine/arginine-rich splicing factor 7 | -0.0150418 |
| H1-4 | H1.4 linker histone, cluster member | -0.0147292 |
| METTL15 | methyltransferase like 15 | -0.01461 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0145533 |
| CANX | calnexin | -0.0145461 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0145426 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | -0.0145219 |
| NDC80 | NDC80 kinetochore complex component | -0.0144705 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0144602 |
| USP53 | ubiquitin specific peptidase 53 | -0.0144549 |
| USPL1 | ubiquitin specific peptidase like 1 | -0.0144455 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0143972 |
| STAG2 | stromal antigen 2 | -0.0143627 |
| RAI14 | retinoic acid induced 14 | -0.0143574 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0143122 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0142996 |
| SYTL2 | synaptotagmin-like 2 | -0.0141445 |
| USP49 | ubiquitin specific peptidase 49 | -0.0141305 |
| KIF18A | kinesin family member 18A | -0.0141042 |
| SART1 | squamous cell carcinoma antigen recognized by T cells | -0.0139216 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.013895 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.013839 |
| ZNF678 | zinc finger protein 678 | -0.0137823 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | -0.0137499 |
| HDAC3 | histone deacetylase 3 | -0.0137262 |
| CDV3 | CDV3 homolog (mouse) | -0.0136865 |
| DPPA4 | developmental pluripotency associated 4 | -0.0134901 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0134371 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0133762 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0133656 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -0.0133649 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0133164 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0132658 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0132464 |
| MIDN | midnolin | -0.0131879 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.0131066 |
| JUN | jun proto-oncogene | -0.0130823 |
| MAMDC2 | MAM domain containing 2 | -0.0130177 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0128899 |
| ZCCHC17 | zinc finger, CCHC domain containing 17 | -0.0128882 |
| LURAP1L | leucine rich adaptor protein 1-like | -0.0128878 |
| PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta | -0.0128829 |
| SLC38A10 | solute carrier family 38, member 10 | -0.0128143 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0127553 |
| XBP1 | X-box binding protein 1 | -0.0126643 |
| ACTN4 | actinin, alpha 4 | -0.0126397 |
| SLC35D2 | solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 | -0.0126108 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0125784 |
| LAMA5 | laminin, alpha 5 | -0.0124863 |
| COX15 | cytochrome c oxidase assembly homolog 15 (yeast) | -0.012479 |
| CCM2 | cerebral cavernous malformation 2 | -0.0124506 |
| ANXA1 | annexin A1 | -0.0124408 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0123528 |
| METTL25 | methyltransferase like 25 | -0.0123415 |
| LPIN1 | lipin 1 | -0.0122585 |
| KLHL5 | kelch-like family member 5 | -0.0122453 |
| PGPEP1L | pyroglutamyl-peptidase I-like | -0.012238 |
| SART3 | squamous cell carcinoma antigen recognized by T cells 3 | -0.0122067 |
| H1-10 | H1.10 linker histone | -0.0121939 |
| TDG | thymine-DNA glycosylase | -0.0121543 |
| EPHA3 | EPH receptor A3 | -0.0121451 |
