Ipatasertib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TGFBI transforming growth factor, beta-induced, 68kDa 0.184159
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.110651
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.083009
NRXN3 neurexin 3 0.0759254
EGFR epidermal growth factor receptor 0.0711765
B2M beta-2-microglobulin 0.0691762
INTS6 integrator complex subunit 6 0.0666262
PRELID2 PRELI domain containing 2 0.065856
BBS9 Bardet-Biedl syndrome 9 0.0635935
ZSWIM6 zinc finger, SWIM-type containing 6 0.0612797
IGFBP3 insulin-like growth factor binding protein 3 0.060619
GSE1 Gse1 coiled-coil protein 0.0603001
FNIP1 folliculin interacting protein 1 0.0586008
ENO1 enolase 1, (alpha) 0.0565333
GOLGB1 golgin B1 0.0548577
MBD5 methyl-CpG binding domain protein 5 0.0514213
ANXA2 annexin A2 0.0512821
EXT1 exostosin glycosyltransferase 1 0.0507996
GLG1 golgi glycoprotein 1 0.0506317
PSD3 pleckstrin and Sec7 domain containing 3 0.0486603
NDRG1 N-myc downstream regulated 1 0.0482863
RPS8 ribosomal protein S8 0.0482022
PRKCA protein kinase C, alpha 0.0476736
MBNL1 muscleblind-like splicing regulator 1 0.0476583
TTC3 tetratricopeptide repeat domain 3 0.0469879
MYOF myoferlin 0.0464073
DSCAM Down syndrome cell adhesion molecule 0.0446979
ASPH aspartate beta-hydroxylase 0.0445942
EXOC4 exocyst complex component 4 0.0445216
TNRC6B trinucleotide repeat containing 6B 0.0434748
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0434003
DST dystonin 0.0432739
CHD9 chromodomain helicase DNA binding protein 9 0.0429594
MBNL2 muscleblind-like splicing regulator 2 0.0427254
N4BP2L2 NEDD4 binding protein 2-like 2 0.0420644
ZBTB20 zinc finger and BTB domain containing 20 0.0419324
PTGES2 prostaglandin E synthase 2 0.0415443
TPT1 tumor protein, translationally-controlled 1 0.0414136
FBXL7 F-box and leucine-rich repeat protein 7 0.0402942
AKAP9 A kinase (PRKA) anchor protein 9 0.0399249
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0397874
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0392532
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0391242
AOPEP aminopeptidase O (putative) 0.0391154
RPL37A ribosomal protein L37a 0.038409
LAMB1 laminin, beta 1 0.0378421
ZZZ3 zinc finger, ZZ-type containing 3 0.0376157
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0375929
SMYD3 SET and MYND domain containing 3 0.0371478
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0370797
CDK13 cyclin-dependent kinase 13 0.0367802
CTNND1 catenin (cadherin-associated protein), delta 1 0.0367113
ARB2A ARB2 cotranscriptional regulator A 0.0366703
ANKRD17 ankyrin repeat domain 17 0.0360847
PDIA6 protein disulfide isomerase family A, member 6 0.0354227
UBE4B ubiquitination factor E4B 0.0351333
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0346994
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0346602
TNS3 tensin 3 0.0346131
ANKIB1 ankyrin repeat and IBR domain containing 1 0.03441
RPL15 ribosomal protein L15 0.0343659
RPS3 ribosomal protein S3 0.0337793
FTL ferritin, light polypeptide 0.0337692
LOXL2 lysyl oxidase-like 2 0.0337135
RPS6 ribosomal protein S6 0.0332932
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.033145
MTDH metadherin 0.032973
DSTN destrin (actin depolymerizing factor) 0.0329334
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0326003
IGF2 insulin-like growth factor 2 0.0324006
CD44 CD44 molecule (Indian blood group) 0.0319336
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0317321
CCDC102B coiled-coil domain containing 102B 0.0315974
SEC31A SEC31 homolog A (S. cerevisiae) 0.0313245
MYO9A myosin IXA 0.0313193
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0299549
WWOX WW domain containing oxidoreductase 0.0297445
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0295375
ATM ATM serine/threonine kinase 0.0294532
VDAC1 voltage-dependent anion channel 1 0.0293922
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.029296
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0292579
FHIT fragile histidine triad 0.029243
BPTF bromodomain PHD finger transcription factor 0.0289211
ZCCHC7 zinc finger, CCHC domain containing 7 0.0288977
PKM pyruvate kinase, muscle 0.0288965
HLA-B major histocompatibility complex, class I, B 0.0288504
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0286478
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0281977
COG5 component of oligomeric golgi complex 5 0.0276778
PHF14 PHD finger protein 14 0.0274265
MAML2 mastermind-like 2 (Drosophila) 0.0271993
RPL9 ribosomal protein L9 0.0271483
COG6 component of oligomeric golgi complex 6 0.0270688
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0269586
COL5A1 collagen, type V, alpha 1 0.0268998
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0268532
FTO fat mass and obesity associated 0.0268342
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0267706
GPATCH8 G patch domain containing 8 0.0267056

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141893
NAMPT nicotinamide phosphoribosyltransferase -0.141171
CXCL8 chemokine (C-X-C motif) ligand 8 -0.130534
TRIO trio Rho guanine nucleotide exchange factor -0.106171
TMSB10 thymosin beta 10 -0.0994843
SDC4 syndecan 4 -0.0810779
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0726333
ATP13A3 ATPase type 13A3 -0.0717256
IL6 interleukin 6 -0.0692718
MT2A metallothionein 2A -0.0656143
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0655785
SOD2 superoxide dismutase 2, mitochondrial -0.0584122
LOX lysyl oxidase -0.0466387
FN1 fibronectin 1 -0.0455517
AKAP12 A kinase (PRKA) anchor protein 12 -0.0450545
ELL2 elongation factor, RNA polymerase II, 2 -0.0436402
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0397269
FTH1 ferritin, heavy polypeptide 1 -0.0394906
HILPDA hypoxia inducible lipid droplet-associated -0.0386553
MAP1B microtubule-associated protein 1B -0.0379839
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0355219
TNIP1 TNFAIP3 interacting protein 1 -0.0350414
RAB8B RAB8B, member RAS oncogene family -0.0343513
GLIS3 GLIS family zinc finger 3 -0.033477
HOOK2 hook microtubule-tethering protein 2 -0.0330931
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0327924
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0327725
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0324586
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0324147
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0323477
KCTD9 potassium channel tetramerization domain containing 9 -0.0318491
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0317938
RBM39 RNA binding motif protein 39 -0.0314853
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0309903
FRMD6 FERM domain containing 6 -0.0309124
F3 coagulation factor III (thromboplastin, tissue factor) -0.0308101
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0308073
FOSL1 FOS-like antigen 1 -0.0306
ZEB2 zinc finger E-box binding homeobox 2 -0.0303493
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0303323
CAMTA1 calmodulin binding transcription activator 1 -0.0300409
ZFC3H1 zinc finger, C3H1-type containing -0.0298708
INHBA inhibin, beta A -0.029732
POTEF POTE ankyrin domain family, member F -0.029354
CYLD cylindromatosis (turban tumor syndrome) -0.029339
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0291746
CALU calumenin -0.0287958
COL1A2 collagen, type I, alpha 2 -0.0285067
RAI14 retinoic acid induced 14 -0.0280269
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.027715
LMAN1 lectin, mannose-binding, 1 -0.0276189
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0274502
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.027285
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.026642
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0263097
ADAM17 ADAM metallopeptidase domain 17 -0.0262854
EGR1 early growth response 1 -0.0262135
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0261532
NOP58 NOP58 ribonucleoprotein -0.0259272
WTAP Wilms tumor 1 associated protein -0.0258287
HMGB2 high mobility group box 2 -0.0257015
ARF4 ADP-ribosylation factor 4 -0.0256742
TFPI2 tissue factor pathway inhibitor 2 -0.0256419
MSN moesin -0.0249539
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0248127
TAGLN2 transgelin 2 -0.0245666
KDM5B lysine (K)-specific demethylase 5B -0.0244252
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0243161
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0242168
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0240351
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0239971
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.023646
IFRD1 interferon-related developmental regulator 1 -0.0235154
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0234049
UGCG UDP-glucose ceramide glucosyltransferase -0.0233864
CDH13 cadherin 13 -0.023342
TSC22D2 TSC22 domain family, member 2 -0.0232763
SOX5 SRY (sex determining region Y)-box 5 -0.0231125
MARCHF6 membrane associated ring-CH-type finger 6 -0.0230434
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0230002
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0229109
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0227885
MT1X metallothionein 1X -0.0227303
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0226373
RTN4 reticulon 4 -0.0225429
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0224434
MAPK8 mitogen-activated protein kinase 8 -0.0221776
RAI1 retinoic acid induced 1 -0.0220752
GARS1 glycyl-tRNA synthetase 1 -0.0218975
MYH9 myosin, heavy chain 9, non-muscle -0.0216729
INSIG1 insulin induced gene 1 -0.0215838
TM9SF3 transmembrane 9 superfamily member 3 -0.021562
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.021514
PPP4R4 protein phosphatase 4, regulatory subunit 4 -0.0213557
COL6A1 collagen, type VI, alpha 1 -0.0212823
STC1 stanniocalcin 1 -0.0212716
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0211601
PID1 phosphotyrosine interaction domain containing 1 -0.0210073
IKBIP IKBKB interacting protein -0.0207913
NRG1 neuregulin 1 -0.0206662