Ipatasertib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ipatasertib perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ipatasertib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZSWIM6 zinc finger, SWIM-type containing 6 0.0768553
SMYD3 SET and MYND domain containing 3 0.0725476
INTS6 integrator complex subunit 6 0.0658305
ANKRD28 ankyrin repeat domain 28 0.0644417
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0552414
RPS12 ribosomal protein S12 0.0536414
MBNL1 muscleblind-like splicing regulator 1 0.0535961
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0507149
ANKRD11 ankyrin repeat domain 11 0.0465868
BICD1 bicaudal D homolog 1 (Drosophila) 0.0461265
DST dystonin 0.045169
TNPO1 transportin 1 0.0445883
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0435707
ERBIN erbb2 interacting protein 0.0421901
GOLGA4 golgin A4 0.0412777
YAP1 Yes-associated protein 1 0.0409801
JARID2 jumonji, AT rich interactive domain 2 0.0408884
CDK13 cyclin-dependent kinase 13 0.0402965
BIRC6 baculoviral IAP repeat containing 6 0.0381564
MBNL2 muscleblind-like splicing regulator 2 0.037384
PCNX4 pecanex 4 0.0359829
RORA RAR-related orphan receptor A 0.0357983
BPTF bromodomain PHD finger transcription factor 0.0353402
RBM25 RNA binding motif protein 25 0.0345087
ARL15 ADP-ribosylation factor-like 15 0.034479
WAC WW domain containing adaptor with coiled-coil 0.0344523
ITCH itchy E3 ubiquitin protein ligase 0.0340142
MED13L mediator complex subunit 13-like 0.0339219
FNIP1 folliculin interacting protein 1 0.0331617
TPT1 tumor protein, translationally-controlled 1 0.0331245
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0329531
ASPH aspartate beta-hydroxylase 0.0323582
RPLP1 ribosomal protein, large, P1 0.0318157
EXT1 exostosin glycosyltransferase 1 0.0316724
WNK1 WNK lysine deficient protein kinase 1 0.0315502
ANKRD17 ankyrin repeat domain 17 0.0312309
TTC17 tetratricopeptide repeat domain 17 0.0310546
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.030775
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0307596
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0304511
FBXL7 F-box and leucine-rich repeat protein 7 0.0303961
RTN3 reticulon 3 0.0303139
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0300491
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0298938
NAP1L1 nucleosome assembly protein 1-like 1 0.0292528
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0292007
ANXA5 annexin A5 0.0288839
ZFAND3 zinc finger, AN1-type domain 3 0.028835
RDX radixin 0.0287477
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.028743
TNRC6B trinucleotide repeat containing 6B 0.0287092
AKAP9 A kinase (PRKA) anchor protein 9 0.0286382
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0285567
MPRIP myosin phosphatase Rho interacting protein 0.028446
SLC38A2 solute carrier family 38, member 2 0.0281545
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0279974
NLK nemo-like kinase 0.0277753
PDE4D phosphodiesterase 4D, cAMP-specific 0.0277074
IRF1 interferon regulatory factor 1 0.0275415
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0274767
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0272978
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0269775
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0264881
OSBPL8 oxysterol binding protein-like 8 0.0264437
MCTP1 multiple C2 domains, transmembrane 1 0.0263944
SATB2 SATB homeobox 2 0.0262513
NCKAP1 NCK-associated protein 1 0.0262064
N4BP2L2 NEDD4 binding protein 2-like 2 0.0257788
TRIM38 tripartite motif containing 38 0.0256419
BCAR3 breast cancer anti-estrogen resistance 3 0.0255394
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0253938
HM13 histocompatibility (minor) 13 0.0253902
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0251745
JMJD1C jumonji domain containing 1C 0.0251543
CERT1 ceramide transporter 1 0.0250992
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0250927
RTN4 reticulon 4 0.0250288
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0249566
BRD2 bromodomain containing 2 0.0248375
TCF12 transcription factor 12 0.0247394
RHOBTB3 Rho-related BTB domain containing 3 0.0246879
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0246159
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0246066
WDPCP WD repeat containing planar cell polarity effector 0.0240127
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.023983
EXOC6B exocyst complex component 6B 0.023968
RPS25 ribosomal protein S25 0.0239032
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0238378
TMEM245 transmembrane protein 245 0.023542
HPCAL1 hippocalcin-like 1 0.0235051
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0234696
UTRN utrophin 0.0229729
BBX bobby sox homolog (Drosophila) 0.0228985
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0227093
SOS1 son of sevenless homolog 1 (Drosophila) 0.0226067
ANXA2 annexin A2 0.0225905
CALU calumenin 0.0223599
NCOR1 nuclear receptor corepressor 1 0.0223156
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0220957
FBXL17 F-box and leucine-rich repeat protein 17 0.0220919

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.107934
VIM vimentin -0.0608005
IGFBP3 insulin-like growth factor binding protein 3 -0.0557607
SDC4 syndecan 4 -0.0503307
DNER delta/notch-like EGF repeat containing -0.0459552
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0454078
LOC112694756 uncharaterized LOC112694756 -0.0446297
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0439459
FTH1 ferritin, heavy polypeptide 1 -0.0418921
HILPDA hypoxia inducible lipid droplet-associated -0.0417674
LDHA lactate dehydrogenase A -0.0392336
IER3 immediate early response 3 -0.0390468
CD44 CD44 molecule (Indian blood group) -0.0373014
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0365863
MSN moesin -0.0359324
TM4SF1 transmembrane 4 L six family member 1 -0.0346284
PRSS23 protease, serine, 23 -0.0341039
SOD2 superoxide dismutase 2, mitochondrial -0.0326805
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0312789
POTEF POTE ankyrin domain family, member F -0.0307738
NT5E 5'-nucleotidase, ecto (CD73) -0.0307408
BTG1 B-cell translocation gene 1, anti-proliferative -0.0305004
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0301381
MAP1B microtubule-associated protein 1B -0.0298589
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0297452
ELL2 elongation factor, RNA polymerase II, 2 -0.0290663
RAI14 retinoic acid induced 14 -0.0278422
BIRC3 baculoviral IAP repeat containing 3 -0.0277224
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0273079
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0271034
IGF2 insulin-like growth factor 2 -0.0264959
NAV2 neuron navigator 2 -0.0256282
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0254892
MACF1 microtubule-actin crosslinking factor 1 -0.025372
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0250246
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0244871
CENPF centromere protein F, 350/400kDa -0.0242284
NAMPT nicotinamide phosphoribosyltransferase -0.0241002
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0236175
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0234692
HMGA2 high mobility group AT-hook 2 -0.0227486
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0224251
PTMA prothymosin, alpha -0.0222805
PBX3 pre-B-cell leukemia homeobox 3 -0.0221583
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0215341
YBX3 Y box binding protein 3 -0.0211502
AHNAK AHNAK nucleoprotein -0.0210064
FNDC3B fibronectin type III domain containing 3B -0.0209687
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0208621
PYGL phosphorylase, glycogen, liver -0.0208021
SEPTIN2 septin 2 -0.0204336
MT2A metallothionein 2A -0.020373
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0201473
RECQL RecQ helicase-like -0.0200464
THSD4 thrombospondin, type I, domain containing 4 -0.0200247
ANGPTL4 angiopoietin-like 4 -0.0199705
RAB5A RAB5A, member RAS oncogene family -0.0199075
EGR1 early growth response 1 -0.0189861
CDCP1 CUB domain containing protein 1 -0.018979
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0188468
PODXL podocalyxin-like -0.0188459
SPDL1 spindle apparatus coiled-coil protein 1 -0.0186001
PFN1 profilin 1 -0.018002
EPAS1 endothelial PAS domain protein 1 -0.0179027
FBXL2 F-box and leucine-rich repeat protein 2 -0.0178759
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0178266
HLA-C major histocompatibility complex, class I, C -0.0175643
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0175625
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0175549
PGK1 phosphoglycerate kinase 1 -0.0174685
BASP1 brain abundant, membrane attached signal protein 1 -0.0174116
ITGAV integrin, alpha V -0.0174088
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0173781
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0173372
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0172942
MCL1 myeloid cell leukemia 1 -0.017196
AKAP13 A kinase (PRKA) anchor protein 13 -0.0171724
BSG basigin (Ok blood group) -0.0169807
ACTG1 actin gamma 1 -0.0168684
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0166092
ACER3 alkaline ceramidase 3 -0.0166048
KMT2A lysine (K)-specific methyltransferase 2A -0.0164795
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0164461
CANX calnexin -0.0163716
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0161265
TPM4 tropomyosin 4 -0.0161114
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0159481
AFF4 AF4/FMR2 family, member 4 -0.0159151
JUN jun proto-oncogene -0.0158578
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0157407
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0156771
MMP12 matrix metallopeptidase 12 -0.0154174
IGFBP4 insulin-like growth factor binding protein 4 -0.0152303
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0151601
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0151322
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0149859
CD59 CD59 molecule, complement regulatory protein -0.0148759
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0147802
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0147372
RRBP1 ribosome binding protein 1 -0.014597