| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.326372 |
| PODXL | podocalyxin-like | 0.189929 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.177265 |
| TMSB10 | thymosin beta 10 | 0.141803 |
| HLA-B | major histocompatibility complex, class I, B | 0.116632 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.105165 |
| SQSTM1 | sequestosome 1 | 0.0959915 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0950515 |
| B2M | beta-2-microglobulin | 0.0731762 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0724156 |
| PGK1 | phosphoglycerate kinase 1 | 0.0709271 |
| LOXL2 | lysyl oxidase-like 2 | 0.0708873 |
| GOLGA4 | golgin A4 | 0.0708748 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0705677 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0636154 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0628256 |
| HLA-A | major histocompatibility complex, class I, A | 0.0616836 |
| ACTG1 | actin gamma 1 | 0.0606357 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0605187 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0587113 |
| FBN1 | fibrillin 1 | 0.0584629 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0559836 |
| NAV2 | neuron navigator 2 | 0.0549203 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0546906 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0515793 |
| AUTS2 | autism susceptibility candidate 2 | 0.051148 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0490284 |
| MSI2 | musashi RNA-binding protein 2 | 0.0488298 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0487235 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0486147 |
| LMNA | lamin A/C | 0.0478853 |
| CSTB | cystatin B (stefin B) | 0.047866 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0474849 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.047478 |
| FLNA | filamin A, alpha | 0.0473724 |
| TAGLN2 | transgelin 2 | 0.0471904 |
| C1D | C1D nuclear receptor corepressor | 0.0469735 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.04673 |
| PRELID2 | PRELI domain containing 2 | 0.0454547 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.044602 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0444633 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0442936 |
| OGA | O-GlcNAcase | 0.0436418 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.043501 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0434394 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.042933 |
| GOLGA2 | golgin A2 | 0.0429163 |
| TMSB4X | thymosin beta 4, X-linked | 0.0428074 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0427782 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0423924 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0421182 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0419122 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0406935 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0404119 |
| HLA-C | major histocompatibility complex, class I, C | 0.0403954 |
| ADM | adrenomedullin | 0.0395711 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.038204 |
| RPL23 | ribosomal protein L23 | 0.0376673 |
| INSIG1 | insulin induced gene 1 | 0.037501 |
| PLEC | plectin | 0.0371287 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0370188 |
| RPL35A | ribosomal protein L35a | 0.0365454 |
| RPS6 | ribosomal protein S6 | 0.0365439 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0355751 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0355113 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.035379 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.035032 |
| PTMA | prothymosin, alpha | 0.0345334 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.034451 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0342654 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0342482 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0341723 |
| SFTPA2 | surfactant protein A2 | 0.0340151 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0338143 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0337163 |
| SBF2 | SET binding factor 2 | 0.0330916 |
| SEPTIN9 | septin 9 | 0.0329528 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0328774 |
| OPTN | optineurin | 0.0322906 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0322428 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.0322083 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0320202 |
| ANK2 | ankyrin 2, neuronal | 0.0317653 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0317007 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.03151 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0313097 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0311624 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0310458 |
| CD109 | CD109 molecule | 0.0307614 |
| RPS19 | ribosomal protein S19 | 0.0307252 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0305537 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0301744 |
| DENND1A | DENN/MADD domain containing 1A | 0.0300791 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0298873 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.029858 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0291996 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.0291743 |
| AHNAK | AHNAK nucleoprotein | 0.0288518 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0287245 |
| MATR3 | matrin 3 | 0.0287112 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.251176 |
| LOX | lysyl oxidase | -0.147348 |
| CD44 | CD44 molecule (Indian blood group) | -0.119401 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101334 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0940441 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0849605 |
| PLAT | plasminogen activator, tissue | -0.0792742 |
| VIM | vimentin | -0.0776216 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0755665 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0589273 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0531068 |
| COL3A1 | collagen, type III, alpha 1 | -0.051351 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0441516 |
| RAI14 | retinoic acid induced 14 | -0.0430673 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0428706 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0422395 |
| ASPH | aspartate beta-hydroxylase | -0.0421348 |
| COL5A2 | collagen, type V, alpha 2 | -0.0417739 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0416008 |
| EFNA5 | ephrin-A5 | -0.0414172 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0410573 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0408428 |
| COL5A1 | collagen, type V, alpha 1 | -0.040438 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0398698 |
| CDH13 | cadherin 13 | -0.0389806 |
| UBC | ubiquitin C | -0.0388483 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0353659 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0353521 |
| NDRG1 | N-myc downstream regulated 1 | -0.0342016 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0339759 |
| S100A10 | S100 calcium binding protein A10 | -0.0339634 |
| MYADM | myeloid-associated differentiation marker | -0.0327188 |
| OSMR | oncostatin M receptor | -0.0322149 |
| STC1 | stanniocalcin 1 | -0.0314702 |
| HDAC9 | histone deacetylase 9 | -0.031193 |
| ZNF207 | zinc finger protein 207 | -0.0307828 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0304914 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0295017 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0294974 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0289855 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.027223 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0270504 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0268763 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0268178 |
| ZNF217 | zinc finger protein 217 | -0.0260892 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0249345 |
| RPS2 | ribosomal protein S2 | -0.0247525 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0244057 |
| MB21D2 | Mab-21 domain containing 2 | -0.0240851 |
| SVIL | supervillin | -0.0228598 |
| RIGI | RNA sensor RIG-I | -0.0226171 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0222904 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0222866 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0220725 |
| IL6ST | interleukin 6 signal transducer | -0.0219413 |
| GLIS3 | GLIS family zinc finger 3 | -0.0215524 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0214002 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0213861 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.021355 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0210384 |
| CLTC | clathrin, heavy chain (Hc) | -0.0206264 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0205569 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0201393 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0199457 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0197458 |
| CCND1 | cyclin D1 | -0.0196935 |
| MX2 | MX dynamin-like GTPase 2 | -0.0189657 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0188227 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.018811 |
| CYTH3 | cytohesin 3 | -0.0186062 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0184173 |
| SLFN5 | schlafen family member 5 | -0.0182341 |
| INTS6 | integrator complex subunit 6 | -0.018001 |
| NAV1 | neuron navigator 1 | -0.0178463 |
| SYTL3 | synaptotagmin-like 3 | -0.0178225 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0177021 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0174883 |
| IPO9 | importin 9 | -0.0173758 |
| DCLK2 | doublecortin-like kinase 2 | -0.0171267 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0170764 |
| ACER3 | alkaline ceramidase 3 | -0.0166782 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0165398 |
| UBXN4 | UBX domain protein 4 | -0.0164333 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0162908 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0162116 |
| SDC4 | syndecan 4 | -0.015899 |
| CANX | calnexin | -0.015773 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0157332 |
| NABP1 | nucleic acid binding protein 1 | -0.0156663 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0155503 |
| VMP1 | vacuole membrane protein 1 | -0.0153856 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | -0.0153608 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0153446 |
| BPTF | bromodomain PHD finger transcription factor | -0.015289 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0151792 |
| EHBP1 | EH domain binding protein 1 | -0.0151451 |
| SEPTIN7 | septin 7 | -0.0151385 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.01512 |
| SP3 | Sp3 transcription factor | -0.0150689 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0148786 |
