| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.113689 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0980423 |
| ACTG1 | actin gamma 1 | 0.0965609 |
| PTMA | prothymosin, alpha | 0.0947826 |
| RPL23 | ribosomal protein L23 | 0.0915895 |
| RPS12 | ribosomal protein S12 | 0.0903216 |
| MED13L | mediator complex subunit 13-like | 0.0777914 |
| CCN2 | cellular communication network factor 2 | 0.0754764 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0753056 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0744224 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0711002 |
| TENM3 | teneurin transmembrane protein 3 | 0.070598 |
| RPS3 | ribosomal protein S3 | 0.0701302 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0682492 |
| CALR | calreticulin | 0.066002 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0647246 |
| CMIP | c-Maf inducing protein | 0.0612128 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0604086 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0597334 |
| SMYD3 | SET and MYND domain containing 3 | 0.057707 |
| TMSB10 | thymosin beta 10 | 0.0574694 |
| HLA-A | major histocompatibility complex, class I, A | 0.0570301 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0560002 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0556774 |
| NEBL | nebulette | 0.0555446 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0526893 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.050173 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0500776 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0492806 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.049012 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0487764 |
| RPL37A | ribosomal protein L37a | 0.0485292 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0475695 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0473663 |
| HDGF | hepatoma-derived growth factor | 0.0465363 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0462393 |
| SETD5 | SET domain containing 5 | 0.0462332 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0462311 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0459067 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.044712 |
| CDK6 | cyclin-dependent kinase 6 | 0.0446374 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0440387 |
| RPL11 | ribosomal protein L11 | 0.043996 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0437597 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0430816 |
| PCBP2 | poly(rC) binding protein 2 | 0.0428054 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0424623 |
| PGK1 | phosphoglycerate kinase 1 | 0.042343 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0423237 |
| CENPF | centromere protein F, 350/400kDa | 0.0422346 |
| RPS21 | ribosomal protein S21 | 0.0419708 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.04196 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0418858 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0413474 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0408729 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.040851 |
| EXOC6B | exocyst complex component 6B | 0.0404639 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0402846 |
| RPS8 | ribosomal protein S8 | 0.040266 |
| RPS19 | ribosomal protein S19 | 0.0401281 |
| MEMO1 | mediator of cell motility 1 | 0.0400973 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.039893 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0395575 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0392518 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0392404 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0391673 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0389604 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0384856 |
| DST | dystonin | 0.0378514 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0377122 |
| EXOC4 | exocyst complex component 4 | 0.0376602 |
| RPLP2 | ribosomal protein, large, P2 | 0.0366883 |
| PRKCE | protein kinase C, epsilon | 0.0365439 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.035825 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0357146 |
| RPL3 | ribosomal protein L3 | 0.0356858 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0354498 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0352668 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0352376 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0352292 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0348936 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0347489 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0342628 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0342118 |
| CPOX | coproporphyrinogen oxidase | 0.0341638 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0340661 |
| EFNA5 | ephrin-A5 | 0.0340052 |
| SRPK2 | SRSF protein kinase 2 | 0.0335044 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0326014 |
| LDHB | lactate dehydrogenase B | 0.0325621 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0325041 |
| RNF213 | ring finger protein 213 | 0.0324433 |
| NBAS | neuroblastoma amplified sequence | 0.0323579 |
| RPL37 | ribosomal protein L37 | 0.0321123 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0318372 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0313526 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0310606 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.031037 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.030883 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0308791 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.252764 |
| AREG | amphiregulin | -0.230769 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.150835 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.139702 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0718122 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.06416 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0598288 |
| PCDH7 | protocadherin 7 | -0.0591872 |
| CCND1 | cyclin D1 | -0.0590136 |
| LMO7 | LIM domain 7 | -0.0578936 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0576383 |
| TMEM41B | transmembrane protein 41B | -0.0540538 |
| IPO7 | importin 7 | -0.0524381 |
| IL6ST | interleukin 6 signal transducer | -0.0509444 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0464722 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0463572 |
| BCHE | butyrylcholinesterase | -0.0458727 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0444585 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0433137 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0420226 |
| TMEM123 | transmembrane protein 123 | -0.0408969 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0408521 |
| MTAP | methylthioadenosine phosphorylase | -0.0389175 |
| VCL | vinculin | -0.0364106 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0362539 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0358464 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.03432 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0332812 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0332773 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0330056 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0323187 |
| ANXA1 | annexin A1 | -0.031943 |
| CLDN1 | claudin 1 | -0.0314876 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0311325 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.030189 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0297162 |
| VMP1 | vacuole membrane protein 1 | -0.029422 |
| MORF4L2 | mortality factor 4 like 2 | -0.0287049 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0284204 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0282361 |
| RPS2 | ribosomal protein S2 | -0.0281975 |
| TXNRD1 | thioredoxin reductase 1 | -0.0281614 |
| KLF6 | Kruppel-like factor 6 | -0.027519 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.027158 |
| SRP72 | signal recognition particle 72kDa | -0.0271402 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0256425 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0251481 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0247495 |
| ZNF217 | zinc finger protein 217 | -0.0246706 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.024625 |
| HELB | helicase (DNA) B | -0.0243908 |
| CCDC47 | coiled-coil domain containing 47 | -0.0241621 |
| NLGN1 | neuroligin 1 | -0.0239919 |
| MMP12 | matrix metallopeptidase 12 | -0.0234417 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0232734 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0232699 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0220978 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0220748 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0220437 |
| TUBB | tubulin, beta class I | -0.0218924 |
| RPLP0 | ribosomal protein, large, P0 | -0.0218437 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0218103 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0217956 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0216279 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.0215011 |
| RAD50 | RAD50 homolog (S. cerevisiae) | -0.0214675 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0214409 |
| EDARADD | EDAR-associated death domain | -0.0213541 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0212245 |
| CANX | calnexin | -0.0209029 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0205239 |
| MASTL | microtubule associated serine/threonine kinase-like | -0.0203697 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0201907 |
| LDHA | lactate dehydrogenase A | -0.0196755 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0195015 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.0194734 |
| HMGA1 | high mobility group AT-hook 1 | -0.019132 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0187324 |
| USP34 | ubiquitin specific peptidase 34 | -0.018713 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0184295 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0181891 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0181069 |
| PARK7 | parkinson protein 7 | -0.0180762 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0179183 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.0178016 |
| XPO7 | exportin 7 | -0.0177459 |
| USP53 | ubiquitin specific peptidase 53 | -0.0175472 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0172624 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0169499 |
| GOLGB1 | golgin B1 | -0.0167078 |
| NRG1 | neuregulin 1 | -0.0166175 |
| MOB1A | MOB kinase activator 1A | -0.0165245 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0164919 |
| INTS10 | integrator complex subunit 10 | -0.0163306 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0162957 |
| CUL1 | cullin 1 | -0.0162851 |
| ATAD5 | ATPase family, AAA domain containing 5 | -0.0162712 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0161776 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0161634 |
| MDH2 | malate dehydrogenase 2, NAD (mitochondrial) | -0.0159127 |
