| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.149029 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.137276 |
| RPS6 | ribosomal protein S6 | 0.116082 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.107994 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.107273 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0963191 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.096089 |
| HLA-B | major histocompatibility complex, class I, B | 0.0927309 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0924797 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0790539 |
| NDRG1 | N-myc downstream regulated 1 | 0.0754645 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0688592 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0665881 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.06561 |
| ADM | adrenomedullin | 0.0615452 |
| RPL35A | ribosomal protein L35a | 0.0610574 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0604659 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0603093 |
| DENND2B | DENN domain containing 2B | 0.0600241 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0591343 |
| PLEC | plectin | 0.0586219 |
| PTK2 | protein tyrosine kinase 2 | 0.0584121 |
| ATP13A3 | ATPase type 13A3 | 0.0566745 |
| USP3 | ubiquitin specific peptidase 3 | 0.0550991 |
| B2M | beta-2-microglobulin | 0.0544789 |
| FMNL2 | formin-like 2 | 0.0527488 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0526988 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0525795 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0514989 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0510934 |
| CADM1 | cell adhesion molecule 1 | 0.0502892 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0492066 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0490462 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0489242 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0487324 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0483261 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0479155 |
| SBF2 | SET binding factor 2 | 0.0476666 |
| MSN | moesin | 0.047654 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.046587 |
| ACTG1 | actin gamma 1 | 0.0463713 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0462603 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0461331 |
| NAV2 | neuron navigator 2 | 0.0459742 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0456198 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0455318 |
| RPS19 | ribosomal protein S19 | 0.0443964 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0441104 |
| WDR43 | WD repeat domain 43 | 0.0440334 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0438353 |
| IRS2 | insulin receptor substrate 2 | 0.0433533 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0424549 |
| FLNA | filamin A, alpha | 0.0423846 |
| GDF15 | growth differentiation factor 15 | 0.0422222 |
| GOLGA4 | golgin A4 | 0.0420658 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0420175 |
| SRPK2 | SRSF protein kinase 2 | 0.0417963 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0416928 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.041503 |
| RND3 | Rho family GTPase 3 | 0.0412828 |
| HELZ | helicase with zinc finger | 0.0411788 |
| RBM39 | RNA binding motif protein 39 | 0.0410842 |
| SMAD3 | SMAD family member 3 | 0.0410775 |
| VEGFA | vascular endothelial growth factor A | 0.0408271 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0403719 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0401485 |
| APOL1 | apolipoprotein L, 1 | 0.0400973 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0398288 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0398017 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0393547 |
| RPS20 | ribosomal protein S20 | 0.0393367 |
| RPL11 | ribosomal protein L11 | 0.0390646 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0383403 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0381436 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0380403 |
| DSTN | destrin (actin depolymerizing factor) | 0.0379906 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0366698 |
| HPCAL1 | hippocalcin-like 1 | 0.0365505 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0364159 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0363858 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0360611 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0360384 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0356491 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0355631 |
| QKI | QKI, KH domain containing, RNA binding | 0.0354588 |
| PML | promyelocytic leukemia | 0.0353391 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0353203 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0352691 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0350598 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0349805 |
| STOM | stomatin | 0.0349613 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0344422 |
| FTL | ferritin, light polypeptide | 0.0342129 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0341676 |
| RPL8 | ribosomal protein L8 | 0.0339972 |
| CALD1 | caldesmon 1 | 0.0337076 |
| RPL3 | ribosomal protein L3 | 0.0332892 |
| EFHD2 | EF-hand domain family, member D2 | 0.0329394 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0329193 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.032788 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | -0.217862 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.148827 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.11789 |
| UBC | ubiquitin C | -0.0838414 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0800346 |
| RPS27A | ribosomal protein S27a | -0.0639948 |
| CD44 | CD44 molecule (Indian blood group) | -0.0639465 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0590024 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.0568637 |
| NRP2 | neuropilin 2 | -0.0526427 |
| KYNU | kynureninase | -0.0516414 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0514544 |
| TXNRD1 | thioredoxin reductase 1 | -0.0482645 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0469982 |
| INTS6 | integrator complex subunit 6 | -0.0445346 |
| JUN | jun proto-oncogene | -0.0428108 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0426383 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0415191 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0406905 |
| VCL | vinculin | -0.0406085 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0391809 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0391598 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0374523 |
| MX1 | MX dynamin-like GTPase 1 | -0.0355028 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0339051 |
| GLIS3 | GLIS family zinc finger 3 | -0.0331181 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0327779 |
| RIGI | RNA sensor RIG-I | -0.0321244 |
| IFI44L | interferon-induced protein 44-like | -0.0320568 |
| ENO1 | enolase 1, (alpha) | -0.0312048 |
| MYOF | myoferlin | -0.0309526 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0307009 |
| AHNAK | AHNAK nucleoprotein | -0.0301821 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0296727 |
| OSMR | oncostatin M receptor | -0.0296691 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0296685 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0294627 |
| SP100 | SP100 nuclear antigen | -0.0293259 |
| HDAC9 | histone deacetylase 9 | -0.0290671 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.027298 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0262896 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0256783 |
| TUT7 | terminal uridylyl transferase 7 | -0.0252466 |
| CDCP1 | CUB domain containing protein 1 | -0.02513 |
| DGKI | diacylglycerol kinase, iota | -0.0249754 |
| SETX | senataxin | -0.023437 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0232163 |
| TMSB10 | thymosin beta 10 | -0.0230715 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.022235 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0219401 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0217516 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0216114 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0216012 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0214748 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0213348 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.0209752 |
| TMEM263 | transmembrane protein 263 | -0.0207671 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0207657 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0204819 |
| FAM20C | family with sequence similarity 20, member C | -0.0203574 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | -0.0201507 |
| GOLGB1 | golgin B1 | -0.019617 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0194084 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0194002 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0193454 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0190449 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0190056 |
| NABP1 | nucleic acid binding protein 1 | -0.0186538 |
| IL6ST | interleukin 6 signal transducer | -0.0184901 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0184652 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0182366 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0182016 |
| GPC6 | glypican 6 | -0.018117 |
| MTAP | methylthioadenosine phosphorylase | -0.0180418 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.017768 |
| CANX | calnexin | -0.0176352 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0175381 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0174428 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0171913 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0171378 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.017124 |
| FHL2 | four and a half LIM domains 2 | -0.0170364 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.016998 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0168567 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0167008 |
| TGFB2 | transforming growth factor, beta 2 | -0.0166523 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0166377 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0166179 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0163506 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0162482 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0161256 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0161233 |
| BICC1 | BicC family RNA binding protein 1 | -0.0161133 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0160328 |
| S100A10 | S100 calcium binding protein A10 | -0.0158398 |
| NAV3 | neuron navigator 3 | -0.0158384 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0158084 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0157384 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0156721 |
| PAX8 | paired box 8 | -0.015454 |
