Irinotecan (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.160001
ACTG1 actin gamma 1 0.111534
TRIO trio Rho guanine nucleotide exchange factor 0.108315
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.105747
PLEC plectin 0.0931251
ANKRD11 ankyrin repeat domain 11 0.0901259
MYH9 myosin, heavy chain 9, non-muscle 0.0876391
NAV2 neuron navigator 2 0.0781115
SHB Src homology 2 domain containing adaptor protein B 0.0765862
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0702535
FLNB filamin B, beta 0.0698702
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0653034
SRRM2 serine/arginine repetitive matrix 2 0.0632125
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.060425
SAMD4A sterile alpha motif domain containing 4A 0.0598881
MSN moesin 0.0571574
FLNA filamin A, alpha 0.0533184
PTPRM protein tyrosine phosphatase, receptor type, M 0.0514825
SMYD3 SET and MYND domain containing 3 0.051134
PGK1 phosphoglycerate kinase 1 0.050735
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0499629
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0492665
PRRC2C proline-rich coiled-coil 2C 0.0489197
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0488843
PTPRJ protein tyrosine phosphatase, receptor type, J 0.04861
EIF1 eukaryotic translation initiation factor 1 0.0484927
PCBP2 poly(rC) binding protein 2 0.0480467
RPL23 ribosomal protein L23 0.0474845
AKAP13 A kinase (PRKA) anchor protein 13 0.0470074
KRT8 keratin 8, type II 0.0468923
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0463127
PTK2 protein tyrosine kinase 2 0.0459885
AOPEP aminopeptidase O (putative) 0.0453331
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0452291
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0442791
IGF1R insulin-like growth factor 1 receptor 0.043022
ANXA4 annexin A4 0.0429868
RPL4 ribosomal protein L4 0.0429834
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0413792
DSCAM Down syndrome cell adhesion molecule 0.0409848
WDR43 WD repeat domain 43 0.0407271
TNIP1 TNFAIP3 interacting protein 1 0.0401895
KRT7 keratin 7, type II 0.0398907
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0396284
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0394852
HSPA8 heat shock 70kDa protein 8 0.0394294
FAM107B family with sequence similarity 107, member B 0.039282
DSTN destrin (actin depolymerizing factor) 0.0392027
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0391673
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.03894
LIMCH1 LIM and calponin homology domains 1 0.0384358
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383822
RPS6 ribosomal protein S6 0.0382968
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0378725
LTBP4 latent transforming growth factor beta binding protein 4 0.0374622
TNS1 tensin 1 0.0366791
MPRIP myosin phosphatase Rho interacting protein 0.0361633
NUP58 nucleoporin 58 0.0358399
ESYT2 extended synaptotagmin-like protein 2 0.035804
KRT18 keratin 18, type I 0.0355737
FMNL2 formin-like 2 0.0354282
RNF145 ring finger protein 145 0.0354232
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0348491
MED13L mediator complex subunit 13-like 0.0345043
MYOF myoferlin 0.0344095
CTBP2 C-terminal binding protein 2 0.0343255
DAPK1 death-associated protein kinase 1 0.0342564
GOLGA4 golgin A4 0.033756
PRKCA protein kinase C, alpha 0.0333592
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0330056
PKM pyruvate kinase, muscle 0.0329527
NACA nascent polypeptide-associated complex alpha subunit 0.0325886
CNTN1 contactin 1 0.0323773
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0321254
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0319489
ACTN4 actinin, alpha 4 0.0315934
CAMTA1 calmodulin binding transcription activator 1 0.0309767
RPS3 ribosomal protein S3 0.0305272
PRELID2 PRELI domain containing 2 0.0303232
MACF1 microtubule-actin crosslinking factor 1 0.0302843
ZMIZ1 zinc finger, MIZ-type containing 1 0.0302165
OGA O-GlcNAcase 0.0301465
BCL2L1 BCL2-like 1 0.0299554
AXL AXL receptor tyrosine kinase 0.0298824
CCNY cyclin Y 0.0298728
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0298212
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0297475
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0293809
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0292254
PACS1 phosphofurin acidic cluster sorting protein 1 0.0291098
SEPTIN9 septin 9 0.0290891
GRB10 growth factor receptor-bound protein 10 0.0290415
MSI2 musashi RNA-binding protein 2 0.0284686
RPS17 ribosomal protein S17 0.028429
EIF4H eukaryotic translation initiation factor 4H 0.0281926
RPL3 ribosomal protein L3 0.0281119
NONO non-POU domain containing, octamer-binding 0.0280603
ZFHX3 zinc finger homeobox 3 0.0277044
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0276803
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0276166

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.206394
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.199345
FTH1 ferritin, heavy polypeptide 1 -0.154877
STAT1 signal transducer and activator of transcription 1, 91kDa -0.102093
OSMR oncostatin M receptor -0.0912697
KYNU kynureninase -0.0850927
STC1 stanniocalcin 1 -0.0846337
FTL ferritin, light polypeptide -0.0805747
MT1X metallothionein 1X -0.0788713
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0783516
C15ORF48 chromosome 15 open reading frame 48 -0.0753606
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0739957
VIM vimentin -0.0739351
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.072669
ANXA2 annexin A2 -0.0724378
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0711977
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0705633
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0689193
NCOA7 nuclear receptor coactivator 7 -0.0666997
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0650855
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0650754
SOD2 superoxide dismutase 2, mitochondrial -0.0649501
RRBP1 ribosome binding protein 1 -0.0589279
MT2A metallothionein 2A -0.0587419
TMSB10 thymosin beta 10 -0.0562911
BASP1 brain abundant, membrane attached signal protein 1 -0.0548825
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0511577
RNF213 ring finger protein 213 -0.0500165
RIGI RNA sensor RIG-I -0.0490295
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0478758
BMAL2 basic helix-loop-helix ARNT like 2 -0.0478418
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0448848
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0447592
KLF6 Kruppel-like factor 6 -0.044628
PLSCR1 phospholipid scramblase 1 -0.0445807
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.044284
UBC ubiquitin C -0.0434301
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0428732
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0422758
IER3 immediate early response 3 -0.0409722
SP100 SP100 nuclear antigen -0.0408756
BTG1 B-cell translocation gene 1, anti-proliferative -0.0403122
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0394686
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0390099
EXT1 exostosin glycosyltransferase 1 -0.0389514
SH3KBP1 SH3-domain kinase binding protein 1 -0.0375184
NAMPT nicotinamide phosphoribosyltransferase -0.0365309
RAI14 retinoic acid induced 14 -0.0361572
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0360498
CD44 CD44 molecule (Indian blood group) -0.0354378
VCL vinculin -0.0352827
LDHA lactate dehydrogenase A -0.0337241
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0335227
IFIH1 interferon induced with helicase C domain 1 -0.033499
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0321595
MORF4L2 mortality factor 4 like 2 -0.0316583
EREG epiregulin -0.0311341
PMP22 peripheral myelin protein 22 -0.0308395
S100A6 S100 calcium binding protein A6 -0.0303501
IFI6 interferon, alpha-inducible protein 6 -0.0302969
KDM7A lysine (K)-specific demethylase 7A -0.0302584
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0300044
ELL2 elongation factor, RNA polymerase II, 2 -0.029966
TDRD7 tudor domain containing 7 -0.0298797
RPS24 ribosomal protein S24 -0.029874
KCTD9 potassium channel tetramerization domain containing 9 -0.0290181
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0288196
NPC1 Niemann-Pick disease, type C1 -0.0283159
PDE10A phosphodiesterase 10A -0.028314
BMERB1 bMERB domain containing 1 -0.0282555
VDAC1 voltage-dependent anion channel 1 -0.0281823
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0279269
IGFBP4 insulin-like growth factor binding protein 4 -0.0276668
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0276588
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0267728
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0267637
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0260107
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0257203
EFNA5 ephrin-A5 -0.0255629
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0254345
RSPO3 R-spondin 3 -0.0253124
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0250821
MYO1E myosin IE -0.0249856
NRIP1 nuclear receptor interacting protein 1 -0.024962
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0248827
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0247093
ARF1 ADP-ribosylation factor 1 -0.0244874
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0244259
SLC38A1 solute carrier family 38, member 1 -0.0242671
RAP1B RAP1B, member of RAS oncogene family -0.0241785
IGFBP3 insulin-like growth factor binding protein 3 -0.0241219
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0240286
DOCK4 dedicator of cytokinesis 4 -0.0240035
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0239314
SAMD9 sterile alpha motif domain containing 9 -0.0238614
RPLP0 ribosomal protein, large, P0 -0.0237304
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0237087
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0235794
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0234119
MX1 MX dynamin-like GTPase 1 -0.0233036