| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.0873563 |
| GSE1 | Gse1 coiled-coil protein | 0.0798044 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0701373 |
| MKI67 | marker of proliferation Ki-67 | 0.06517 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0647162 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0645058 |
| PRELID2 | PRELI domain containing 2 | 0.0639291 |
| RANBP17 | RAN binding protein 17 | 0.0630947 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0629098 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0627281 |
| CENPF | centromere protein F, 350/400kDa | 0.0621416 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0596634 |
| DIAPH3 | diaphanous-related formin 3 | 0.0568185 |
| TPX2 | TPX2, microtubule-associated | 0.0550356 |
| VEGFA | vascular endothelial growth factor A | 0.0547115 |
| KIF11 | kinesin family member 11 | 0.053285 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0493661 |
| ZNF292 | zinc finger protein 292 | 0.0485927 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0480795 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0473298 |
| PCBP2 | poly(rC) binding protein 2 | 0.0471923 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.045783 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0453911 |
| RBM33 | RNA binding motif protein 33 | 0.0453161 |
| OGA | O-GlcNAcase | 0.0442422 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0437333 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0433777 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0430079 |
| RPL23 | ribosomal protein L23 | 0.0421542 |
| BBX | bobby sox homolog (Drosophila) | 0.0419497 |
| SMYD3 | SET and MYND domain containing 3 | 0.0417855 |
| BOC | BOC cell adhesion associated, oncogene regulated | 0.0394911 |
| ZNF148 | zinc finger protein 148 | 0.0388953 |
| CCNB1 | cyclin B1 | 0.0387615 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0381742 |
| KIF23 | kinesin family member 23 | 0.0380875 |
| LMNB1 | lamin B1 | 0.0380812 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0377934 |
| CENPE | centromere protein E, 312kDa | 0.0376176 |
| KAZN | kazrin, periplakin interacting protein | 0.0373918 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0370613 |
| RAD51B | RAD51 paralog B | 0.0368609 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0366565 |
| H1-2 | H1.2 linker histone, cluster member | 0.0358973 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0358186 |
| H1-4 | H1.4 linker histone, cluster member | 0.0354036 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0350836 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0350571 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0345765 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0342828 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0337295 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0334859 |
| PTEN | phosphatase and tensin homolog | 0.0333881 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0333369 |
| BUB3 | BUB3 mitotic checkpoint protein | 0.0331796 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0331657 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0323619 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0322561 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0321886 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0319579 |
| RPL3 | ribosomal protein L3 | 0.0318447 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0309859 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0308587 |
| TBCD | tubulin folding cofactor D | 0.030644 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0304146 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0303636 |
| RNF130 | ring finger protein 130 | 0.0299756 |
| UTRN | utrophin | 0.0298599 |
| ANLN | anillin, actin binding protein | 0.0296534 |
| PHF21A | PHD finger protein 21A | 0.0295414 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0295411 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0288008 |
| WDR11 | WD repeat domain 11 | 0.0283993 |
| PKP4 | plakophilin 4 | 0.0283433 |
| SPAG5 | sperm associated antigen 5 | 0.0283345 |
| DIPK2A | divergent protein kinase domain 2A | 0.0282068 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0280702 |
| RSBN1L | round spermatid basic protein 1-like | 0.0280615 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0279723 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.0278783 |
| BRD2 | bromodomain containing 2 | 0.0277213 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.0276836 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0276465 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0275811 |
| DOCK1 | dedicator of cytokinesis 1 | 0.027556 |
| NAV1 | neuron navigator 1 | 0.0273198 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0272418 |
| SFTPA2 | surfactant protein A2 | 0.0270768 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0270639 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0268941 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0265417 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.0264801 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.0262612 |
| RPL26 | ribosomal protein L26 | 0.0262309 |
| B2M | beta-2-microglobulin | 0.0259824 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.025936 |
| KIF20B | kinesin family member 20B | 0.0259011 |
| MTPN | myotrophin | 0.0257722 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0257431 |
| TRIM2 | tripartite motif containing 2 | 0.0254657 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | -0.18501 |
| VIM | vimentin | -0.163896 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.154607 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.123193 |
| CADM2 | cell adhesion molecule 2 | -0.113764 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.111374 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0900043 |
| IER3 | immediate early response 3 | -0.0865004 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0809969 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0755618 |
| MGP | matrix Gla protein | -0.0751243 |
| FNDC3B | fibronectin type III domain containing 3B | -0.06592 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0591071 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0576448 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0564638 |
| MT2A | metallothionein 2A | -0.0542015 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0506745 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0492452 |
| RPL35A | ribosomal protein L35a | -0.048163 |
| ITGAV | integrin, alpha V | -0.0479421 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.045826 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0452506 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.043282 |
| MYOF | myoferlin | -0.0423113 |
| CANX | calnexin | -0.0421841 |
| FTL | ferritin, light polypeptide | -0.0419715 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0409703 |
| QKI | QKI, KH domain containing, RNA binding | -0.040691 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.039364 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0388492 |
| YBX1 | Y box binding protein 1 | -0.0383386 |
| HMGA1 | high mobility group AT-hook 1 | -0.0382043 |
| HMGA2 | high mobility group AT-hook 2 | -0.038141 |
| TFRC | transferrin receptor | -0.0374623 |
| HMGB1 | high mobility group box 1 | -0.0371202 |
| MB21D2 | Mab-21 domain containing 2 | -0.0361279 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0358325 |
| TUT4 | terminal uridylyl transferase 4 | -0.035339 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0351337 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0345576 |
| RPS19 | ribosomal protein S19 | -0.0342949 |
| PHF3 | PHD finger protein 3 | -0.0338029 |
| PCDH7 | protocadherin 7 | -0.0329838 |
| TMSB10 | thymosin beta 10 | -0.0324515 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0323851 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0322915 |
| RPLP1 | ribosomal protein, large, P1 | -0.0318894 |
| PEG10 | paternally expressed 10 | -0.0304267 |
| VCL | vinculin | -0.0302889 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.030255 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0300664 |
| FBXO11 | F-box protein 11 | -0.0292697 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0289042 |
| COL5A2 | collagen, type V, alpha 2 | -0.028531 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0283508 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0282371 |
| KIF5B | kinesin family member 5B | -0.0281315 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0278268 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0269354 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0268692 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0267954 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.026142 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.025929 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0253187 |
| IPO7 | importin 7 | -0.0248911 |
| PCM1 | pericentriolar material 1 | -0.0247277 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0245537 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0245513 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0243338 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0241747 |
| POTEF | POTE ankyrin domain family, member F | -0.0241116 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0237627 |
| COMMD10 | COMM domain containing 10 | -0.0236872 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0235627 |
| PARK7 | parkinson protein 7 | -0.0234527 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.0232923 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0229886 |
| ZNF217 | zinc finger protein 217 | -0.0229111 |
| RPS24 | ribosomal protein S24 | -0.0228584 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0225578 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | -0.0225571 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0224649 |
| MICU1 | mitochondrial calcium uptake 1 | -0.0224228 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.022369 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0223524 |
| GSPT1 | G1 to S phase transition 1 | -0.0223484 |
| FAM193A | family with sequence similarity 193, member A | -0.0223251 |
| WDR43 | WD repeat domain 43 | -0.0222232 |
| HBP1 | HMG-box transcription factor 1 | -0.0219827 |
| ACTG1 | actin gamma 1 | -0.0218894 |
| PPHLN1 | periphilin 1 | -0.0217025 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0215989 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.0215428 |
| EGR1 | early growth response 1 | -0.0213569 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.021329 |
| ZNF431 | zinc finger protein 431 | -0.0212173 |
| OLA1 | Obg-like ATPase 1 | -0.0211973 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0210709 |
| YY1 | YY1 transcription factor | -0.0210505 |
| CREM | cAMP responsive element modulator | -0.0210395 |
