| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | 0.201585 |
| LAMB3 | laminin, beta 3 | 0.193693 |
| FLNB | filamin B, beta | 0.147942 |
| PLEC | plectin | 0.147403 |
| PGK1 | phosphoglycerate kinase 1 | 0.140074 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.139971 |
| EZR | ezrin | 0.124479 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.114168 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.109837 |
| KRT8 | keratin 8, type II | 0.103502 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.103387 |
| KRT18 | keratin 18, type I | 0.0981473 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0852658 |
| LOC112694756 | uncharaterized LOC112694756 | 0.084184 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0834342 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0808867 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0804742 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0759279 |
| AHNAK | AHNAK nucleoprotein | 0.0752277 |
| ACTG1 | actin gamma 1 | 0.0723022 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0715913 |
| FAM107B | family with sequence similarity 107, member B | 0.0695448 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0694961 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.069021 |
| NPSR1 | neuropeptide S receptor 1 | 0.067576 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0673687 |
| PTMA | prothymosin, alpha | 0.066884 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0665227 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0664477 |
| OGA | O-GlcNAcase | 0.0646229 |
| FAM13A | family with sequence similarity 13, member A | 0.0613039 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0596903 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 0.0579537 |
| B2M | beta-2-microglobulin | 0.0570392 |
| KLK10 | kallikrein-related peptidase 10 | 0.0554913 |
| DIAPH1 | diaphanous-related formin 1 | 0.0545322 |
| RPL35A | ribosomal protein L35a | 0.0529034 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | 0.0528435 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0521994 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0509218 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0506727 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0505228 |
| ANXA11 | annexin A11 | 0.0497289 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0495974 |
| PRELID2 | PRELI domain containing 2 | 0.049525 |
| PTK2 | protein tyrosine kinase 2 | 0.0490347 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0485435 |
| ACTN4 | actinin, alpha 4 | 0.0478366 |
| ITGB4 | integrin, beta 4 | 0.0474208 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.047288 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0451653 |
| LMO7 | LIM domain 7 | 0.0446463 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0445001 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0441832 |
| HLA-A | major histocompatibility complex, class I, A | 0.044027 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0438443 |
| SMAD3 | SMAD family member 3 | 0.043504 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0433633 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0432644 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0423182 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0416921 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0414561 |
| ZNF292 | zinc finger protein 292 | 0.0413247 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0408323 |
| ANKRD11 | ankyrin repeat domain 11 | 0.040029 |
| RPL23 | ribosomal protein L23 | 0.0392636 |
| RPS20 | ribosomal protein S20 | 0.0392494 |
| SULF2 | sulfatase 2 | 0.0387209 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0386567 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0377065 |
| MXD1 | MAX dimerization protein 1 | 0.0375601 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0372801 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0371983 |
| RPS6 | ribosomal protein S6 | 0.037066 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0370203 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0364926 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0356639 |
| LDHA | lactate dehydrogenase A | 0.035042 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0347552 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0346503 |
| EMP1 | epithelial membrane protein 1 | 0.0346014 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0345714 |
| RRBP1 | ribosome binding protein 1 | 0.0345477 |
| OPTN | optineurin | 0.0345201 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0343696 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.033829 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0337381 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.033517 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0335113 |
| TXNIP | thioredoxin interacting protein | 0.0333587 |
| FAT1 | FAT atypical cadherin 1 | 0.0332167 |
| PMM2 | phosphomannomutase 2 | 0.0329607 |
| CD9 | CD9 molecule | 0.0328312 |
| RNF213 | ring finger protein 213 | 0.0318361 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0311396 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0308849 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0305008 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0303184 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0302843 |
| RNF145 | ring finger protein 145 | 0.0302443 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.158934 |
| NDRG1 | N-myc downstream regulated 1 | -0.146392 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.120319 |
| RPS2 | ribosomal protein S2 | -0.100423 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0703833 |
| EFNA5 | ephrin-A5 | -0.0641824 |
| ASPH | aspartate beta-hydroxylase | -0.0626405 |
| VCL | vinculin | -0.0617717 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.053405 |
| ITGA6 | integrin, alpha 6 | -0.0499368 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0454143 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0446882 |
| RTN4 | reticulon 4 | -0.041588 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0407395 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0386368 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0384987 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0372707 |
| IPO7 | importin 7 | -0.037052 |
| S100A10 | S100 calcium binding protein A10 | -0.0360216 |
| FOSL1 | FOS-like antigen 1 | -0.0354193 |
| CDCP1 | CUB domain containing protein 1 | -0.0349698 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0347975 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0341288 |
| SPAG9 | sperm associated antigen 9 | -0.0330984 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0324977 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0322482 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0317134 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0309729 |
| DSG2 | desmoglein 2 | -0.0302776 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.0282352 |
| HMGA1 | high mobility group AT-hook 1 | -0.0280176 |
| SEPTIN9 | septin 9 | -0.0275829 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0273925 |
| STK4 | serine/threonine kinase 4 | -0.0272751 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0270113 |
| CLTC | clathrin, heavy chain (Hc) | -0.0269714 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0269605 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0267872 |
| WWC1 | WW and C2 domain containing 1 | -0.0263558 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0260289 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0257691 |
| LAMC2 | laminin, gamma 2 | -0.0257579 |
| NUP98 | nucleoporin 98kDa | -0.0257538 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0254855 |
| USP53 | ubiquitin specific peptidase 53 | -0.0252803 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.0243444 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0242974 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0242829 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0238629 |
| RESF1 | retroelement silencing factor 1 | -0.02359 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0233851 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0233283 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0232979 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.022487 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0220712 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0216794 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0214199 |
| SACK1B | scaffolding CK1 anchoring protein B | -0.0213026 |
| USP34 | ubiquitin specific peptidase 34 | -0.0212323 |
| ARRDC3 | arrestin domain containing 3 | -0.0212163 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0211176 |
| RPL7 | ribosomal protein L7 | -0.0206242 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0198684 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0196946 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0194555 |
| USP12 | ubiquitin specific peptidase 12 | -0.0193278 |
| ANXA5 | annexin A5 | -0.0191889 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.0191471 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0191291 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0190519 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0189193 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0188452 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0187757 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0186799 |
| ACER3 | alkaline ceramidase 3 | -0.0185615 |
| RCOR1 | REST corepressor 1 | -0.0184861 |
| SNX9 | sorting nexin 9 | -0.0183898 |
| ITGAV | integrin, alpha V | -0.0181336 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0180482 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0179313 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0178718 |
| RPL6 | ribosomal protein L6 | -0.017778 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0177598 |
| UBC | ubiquitin C | -0.0176723 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0176033 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.017425 |
| ATG12 | autophagy related 12 | -0.0173568 |
| TMEM123 | transmembrane protein 123 | -0.0171293 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | -0.016964 |
| TMED7 | transmembrane emp24 protein transport domain containing 7 | -0.01677 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0167537 |
| GOLT1B | golgi transport 1B | -0.0166908 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0165283 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0164765 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0163139 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0162694 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0162217 |
| MUC17 | mucin 17, cell surface associated | -0.0161586 |
| RPL5 | ribosomal protein L5 | -0.0159974 |
| SCYL2 | SCY1-like 2 (S. cerevisiae) | -0.0158186 |
