| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEP250 | centrosomal protein 250kDa | 0.143435 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.137477 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.119011 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.11412 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.102038 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0979788 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0963042 |
| PLEC | plectin | 0.090717 |
| LASP1 | LIM and SH3 protein 1 | 0.0906984 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0894445 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0715616 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.0662871 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0574685 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0546035 |
| VEGFA | vascular endothelial growth factor A | 0.0509579 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0493201 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0472529 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0470037 |
| GRB7 | growth factor receptor-bound protein 7 | 0.0468447 |
| DSTN | destrin (actin depolymerizing factor) | 0.0466484 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | 0.0462231 |
| GSE1 | Gse1 coiled-coil protein | 0.0461003 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0449838 |
| PNN | pinin, desmosome associated protein | 0.0448391 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0444061 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0438275 |
| FASN | fatty acid synthase | 0.0409795 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.039927 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0398303 |
| MSI2 | musashi RNA-binding protein 2 | 0.0389541 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0388375 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0387886 |
| KIF16B | kinesin family member 16B | 0.0382601 |
| KRT18 | keratin 18, type I | 0.0380226 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0377573 |
| BRD4 | bromodomain containing 4 | 0.0361807 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0361196 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0351525 |
| RBM25 | RNA binding motif protein 25 | 0.0343208 |
| FADS2 | fatty acid desaturase 2 | 0.0343027 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0334427 |
| SETD5 | SET domain containing 5 | 0.0326256 |
| KRT7 | keratin 7, type II | 0.0326141 |
| GSDMB | gasdermin B | 0.0324118 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0319063 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0317701 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0312291 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0311843 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 0.0310249 |
| GOLGA2 | golgin A2 | 0.0308738 |
| YAP1 | Yes-associated protein 1 | 0.0307356 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0307104 |
| TAPBP | TAP binding protein (tapasin) | 0.0306118 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0305107 |
| YEATS2 | YEATS domain containing 2 | 0.0301226 |
| SF1 | splicing factor 1 | 0.0298663 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0298249 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0297995 |
| LRRC59 | leucine rich repeat containing 59 | 0.0296651 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.029563 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0295353 |
| FOXO3 | forkhead box O3 | 0.0295082 |
| ACTG1 | actin gamma 1 | 0.02909 |
| DHFR | dihydrofolate reductase | 0.0289568 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0288878 |
| SET | SET nuclear proto-oncogene | 0.0286963 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0286009 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.028226 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0281776 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0281157 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0281146 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0281 |
| PRRC2A | proline-rich coiled-coil 2A | 0.027909 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0278484 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0277887 |
| SHROOM3 | shroom family member 3 | 0.0277855 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0275305 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0275075 |
| KIAA1217 | KIAA1217 | 0.0272448 |
| TPD52 | tumor protein D52 | 0.027226 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0272077 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0270713 |
| NDRG1 | N-myc downstream regulated 1 | 0.0270498 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.026975 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0269135 |
| MYO10 | myosin X | 0.0266284 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.026609 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0265674 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0265009 |
| RPL3 | ribosomal protein L3 | 0.0264027 |
| VMP1 | vacuole membrane protein 1 | 0.0263173 |
| FAM168A | family with sequence similarity 168, member A | 0.026262 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0260522 |
| KIF1A | kinesin family member 1A | 0.0258998 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0253402 |
| BRD2 | bromodomain containing 2 | 0.0252639 |
| HDGF | hepatoma-derived growth factor | 0.0252557 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.025243 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0249145 |
| ATP9A | ATPase, class II, type 9A | 0.0246004 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.137548 |
| ASPH | aspartate beta-hydroxylase | -0.122902 |
| RPL23 | ribosomal protein L23 | -0.0961917 |
| CCND1 | cyclin D1 | -0.088296 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0841828 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0797361 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0787922 |
| SMYD3 | SET and MYND domain containing 3 | -0.077551 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0769852 |
| CDK12 | cyclin-dependent kinase 12 | -0.0745143 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0738017 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0701314 |
| MT2A | metallothionein 2A | -0.0663751 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0643698 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0637832 |
| NTN4 | netrin 4 | -0.0628347 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0622262 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0604513 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.060218 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0583885 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0567103 |
| MYOF | myoferlin | -0.0551688 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0545867 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0542687 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0509761 |
| RPL19 | ribosomal protein L19 | -0.0499735 |
| TMSB10 | thymosin beta 10 | -0.0496985 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0493042 |
| PTMA | prothymosin, alpha | -0.049226 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0483157 |
| S100A9 | S100 calcium binding protein A9 | -0.0480459 |
| UBC | ubiquitin C | -0.0470641 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0465998 |
| AHNAK | AHNAK nucleoprotein | -0.0448878 |
| TMEM123 | transmembrane protein 123 | -0.0427639 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0427558 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0421655 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0411227 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0402226 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0398731 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0393555 |
| OSMR | oncostatin M receptor | -0.0393249 |
| LDHA | lactate dehydrogenase A | -0.03904 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0389611 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0388817 |
| CANX | calnexin | -0.0382933 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0371847 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0367878 |
| SDC4 | syndecan 4 | -0.0367752 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0365814 |
| TXNRD1 | thioredoxin reductase 1 | -0.0358959 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0354452 |
| SP100 | SP100 nuclear antigen | -0.0352093 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0351381 |
| ANXA2 | annexin A2 | -0.0351036 |
| S100A8 | S100 calcium binding protein A8 | -0.03475 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0347297 |
| S100A6 | S100 calcium binding protein A6 | -0.0332989 |
| ENO1 | enolase 1, (alpha) | -0.0327273 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0326484 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0316841 |
| DSG2 | desmoglein 2 | -0.0315719 |
| IER3 | immediate early response 3 | -0.0315239 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0302131 |
| AREG | amphiregulin | -0.029909 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0295011 |
| RPL12 | ribosomal protein L12 | -0.0294566 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0292392 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0289657 |
| ITGB6 | integrin, beta 6 | -0.0288862 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0286321 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.028608 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0283102 |
| RPL34 | ribosomal protein L34 | -0.0283001 |
| TUBB | tubulin, beta class I | -0.0281339 |
| NF1 | neurofibromin 1 | -0.0281222 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0278918 |
| ZNF217 | zinc finger protein 217 | -0.0278753 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0278675 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0277362 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.027683 |
| SBF2 | SET binding factor 2 | -0.0274309 |
| RPS27A | ribosomal protein S27a | -0.0272267 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0272148 |
| HMGB1 | high mobility group box 1 | -0.0271071 |
| RPS24 | ribosomal protein S24 | -0.026996 |
| CCNI | cyclin I | -0.0267842 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0267414 |
| S100A7 | S100 calcium binding protein A7 | -0.0266675 |
| CLTC | clathrin, heavy chain (Hc) | -0.0264989 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0254321 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0252472 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0251519 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0247009 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0246069 |
| DUSP16 | dual specificity phosphatase 16 | -0.0245934 |
| GATA3 | GATA binding protein 3 | -0.0243139 |
| AHR | aryl hydrocarbon receptor | -0.0238656 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0237616 |
| JUN | jun proto-oncogene | -0.0234118 |
