| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMYD3 | SET and MYND domain containing 3 | 0.123568 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.111904 |
| NFIA | nuclear factor I/A | 0.109978 |
| DST | dystonin | 0.104885 |
| ZNF292 | zinc finger protein 292 | 0.0925334 |
| AUTS2 | autism susceptibility candidate 2 | 0.0813791 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0759344 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0728559 |
| PGK1 | phosphoglycerate kinase 1 | 0.0652219 |
| TOX | thymocyte selection-associated high mobility group box | 0.0647025 |
| ARFGEF3 | ARFGEF family member 3 | 0.0643765 |
| YEATS2 | YEATS domain containing 2 | 0.0619469 |
| ZNF608 | zinc finger protein 608 | 0.057792 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0573424 |
| CABIN1 | calcineurin binding protein 1 | 0.0572814 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0566165 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0553441 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0552204 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0552183 |
| OGA | O-GlcNAcase | 0.0549986 |
| HELZ | helicase with zinc finger | 0.0549846 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0549819 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0548516 |
| EFNA5 | ephrin-A5 | 0.0529849 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0526638 |
| CDH18 | cadherin 18, type 2 | 0.0521603 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0517898 |
| ATRN | attractin | 0.0514487 |
| KIAA1958 | KIAA1958 | 0.050625 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0504567 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0496017 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0494802 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0488505 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.048784 |
| RPL4 | ribosomal protein L4 | 0.047168 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0470365 |
| PHF21A | PHD finger protein 21A | 0.046968 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0465987 |
| FMNL2 | formin-like 2 | 0.0462195 |
| NGLY1 | N-glycanase 1 | 0.0454799 |
| RPL11 | ribosomal protein L11 | 0.0447353 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0440068 |
| RPS4X | ribosomal protein S4, X-linked | 0.0439937 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0430877 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0417351 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0417109 |
| PRELID2 | PRELI domain containing 2 | 0.0416504 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0413643 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0413273 |
| NEBL | nebulette | 0.0413075 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0409465 |
| PTCH1 | patched 1 | 0.0399301 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0398565 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0396065 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0394283 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0392612 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0391541 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0385927 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0385735 |
| EXOC6B | exocyst complex component 6B | 0.0384756 |
| SET | SET nuclear proto-oncogene | 0.0384148 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0383664 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0379203 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0379019 |
| RPL3 | ribosomal protein L3 | 0.0377984 |
| SBF2 | SET binding factor 2 | 0.0376495 |
| MED13L | mediator complex subunit 13-like | 0.0372538 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0370856 |
| RBM33 | RNA binding motif protein 33 | 0.0370112 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0368311 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0367598 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0367552 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0367194 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0362871 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0361131 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0360278 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.035644 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0353206 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0353052 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0351543 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0348205 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0346945 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0346666 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0345793 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0344901 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0342575 |
| BBX | bobby sox homolog (Drosophila) | 0.033792 |
| RLF | rearranged L-myc fusion | 0.0336408 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.033618 |
| FOXO3 | forkhead box O3 | 0.0335938 |
| TPI1 | triosephosphate isomerase 1 | 0.0334871 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0331506 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0330162 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0329707 |
| PTK2 | protein tyrosine kinase 2 | 0.0327813 |
| H1-4 | H1.4 linker histone, cluster member | 0.0327017 |
| RORA | RAR-related orphan receptor A | 0.0317474 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0317236 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0315384 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0314835 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLIT2 | slit homolog 2 (Drosophila) | -0.185298 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0895514 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0764695 |
| PTMA | prothymosin, alpha | -0.0710538 |
| RPLP1 | ribosomal protein, large, P1 | -0.0583282 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0560163 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0534762 |
| RIGI | RNA sensor RIG-I | -0.0519535 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.048755 |
| VMP1 | vacuole membrane protein 1 | -0.0471101 |
| VCL | vinculin | -0.0458947 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0430591 |
| TENM3 | teneurin transmembrane protein 3 | -0.0416867 |
| COL5A2 | collagen, type V, alpha 2 | -0.0409663 |
| ACTG1 | actin gamma 1 | -0.0406113 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.037992 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.037263 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0345652 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0344224 |
| HHIP | hedgehog interacting protein | -0.0344145 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0331147 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0323892 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0295386 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0280962 |
| RAB10 | RAB10, member RAS oncogene family | -0.0262254 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0260544 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -0.0260478 |
| INTS6 | integrator complex subunit 6 | -0.0258406 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0254837 |
| FTL | ferritin, light polypeptide | -0.0254383 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0253018 |
| NRG1 | neuregulin 1 | -0.0251605 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0249836 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0249359 |
| HMGB1 | high mobility group box 1 | -0.0248232 |
| UBAP2 | ubiquitin associated protein 2 | -0.0243834 |
| PMP22 | peripheral myelin protein 22 | -0.0240501 |
| RPL35A | ribosomal protein L35a | -0.0238221 |
| RPL28 | ribosomal protein L28 | -0.0230048 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0224708 |
| CCDC138 | coiled-coil domain containing 138 | -0.0223573 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0215225 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0213059 |
| PHF14 | PHD finger protein 14 | -0.0209336 |
| E2F3 | E2F transcription factor 3 | -0.0208975 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0208323 |
| CANX | calnexin | -0.0206735 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0206229 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0204932 |
| ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 | -0.0201776 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.01995 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.019758 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0197062 |
| VEGFC | vascular endothelial growth factor C | -0.0195855 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0194643 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0192958 |
| HMGA1 | high mobility group AT-hook 1 | -0.0192726 |
| RSU1 | Ras suppressor protein 1 | -0.0192571 |
| SHISA5 | shisa family member 5 | -0.0191781 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0191419 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0191116 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0191013 |
| RPS2 | ribosomal protein S2 | -0.0189 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0188827 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0188333 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0184699 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0184313 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0183552 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0183298 |
| RPS29 | ribosomal protein S29 | -0.0182286 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0180708 |
| ZNF207 | zinc finger protein 207 | -0.0179979 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0179927 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0178775 |
| HSPA4 | heat shock 70kDa protein 4 | -0.0178544 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0178062 |
| SETX | senataxin | -0.0176859 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0176485 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0176383 |
| RABEP1 | rabaptin, RAB GTPase binding effector protein 1 | -0.0174638 |
| HIRA | histone cell cycle regulator | -0.0172955 |
| TRAP1 | TNF receptor-associated protein 1 | -0.0172421 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0171351 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0170957 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | -0.0170096 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.016738 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | -0.0166811 |
| BCL2L13 | BCL2-like 13 (apoptosis facilitator) | -0.0166172 |
| C1ORF159 | chromosome 1 open reading frame 159 | -0.0164994 |
| EGR1 | early growth response 1 | -0.016462 |
| WLS | wntless Wnt ligand secretion mediator | -0.0164293 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0162963 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0162622 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0161605 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.016039 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0159642 |
| GSPT1 | G1 to S phase transition 1 | -0.0159109 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0159072 |
| SIK3 | SIK family kinase 3 | -0.0157272 |
| B2M | beta-2-microglobulin | -0.0157231 |
