| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VGF | VGF nerve growth factor inducible | 0.128332 |
| LOC112694756 | uncharaterized LOC112694756 | 0.115771 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.1083 |
| CD109 | CD109 molecule | 0.100556 |
| HLA-B | major histocompatibility complex, class I, B | 0.0942164 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0844505 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0828122 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0825824 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0786838 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.073928 |
| NAV2 | neuron navigator 2 | 0.0732382 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0685186 |
| PGK1 | phosphoglycerate kinase 1 | 0.0669535 |
| NDRG1 | N-myc downstream regulated 1 | 0.0645093 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0643557 |
| CDC73 | cell division cycle 73 | 0.0640752 |
| ANKRD11 | ankyrin repeat domain 11 | 0.061175 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0609872 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0607423 |
| RBM33 | RNA binding motif protein 33 | 0.0593549 |
| SMAD3 | SMAD family member 3 | 0.0559188 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0550974 |
| CABIN1 | calcineurin binding protein 1 | 0.0548807 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0532806 |
| GPC6 | glypican 6 | 0.0523857 |
| PRELID2 | PRELI domain containing 2 | 0.0506517 |
| RPL3 | ribosomal protein L3 | 0.0506003 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0505682 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0501538 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0486447 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0485784 |
| PLEC | plectin | 0.0483113 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0479144 |
| CTTNBP2 | cortactin binding protein 2 | 0.0477892 |
| FBXO7 | F-box protein 7 | 0.047394 |
| RNF145 | ring finger protein 145 | 0.0466246 |
| SRPK2 | SRSF protein kinase 2 | 0.0441137 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0440528 |
| ATXN1 | ataxin 1 | 0.0437575 |
| SEPTIN9 | septin 9 | 0.0433778 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0433319 |
| TPI1 | triosephosphate isomerase 1 | 0.0421202 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0421008 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0420199 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0417903 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0416717 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0413891 |
| CENPF | centromere protein F, 350/400kDa | 0.0411817 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0410671 |
| BBX | bobby sox homolog (Drosophila) | 0.0404985 |
| PDE10A | phosphodiesterase 10A | 0.0403977 |
| SFTPA2 | surfactant protein A2 | 0.0403754 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0403252 |
| MKRN1 | makorin ring finger protein 1 | 0.038584 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0385438 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0384797 |
| POM121 | POM121 transmembrane nucleoporin | 0.0384748 |
| MED13L | mediator complex subunit 13-like | 0.0379965 |
| TAGLN2 | transgelin 2 | 0.0372517 |
| IGF1R | insulin-like growth factor 1 receptor | 0.036978 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0367396 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0363873 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0363847 |
| TNNC1 | troponin C type 1 (slow) | 0.0360786 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0359786 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.03589 |
| RNF213 | ring finger protein 213 | 0.0354964 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0353098 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0349477 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0346747 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0341898 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | 0.0339128 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0334239 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0333682 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0332499 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0331375 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0330562 |
| RUNX1 | runt-related transcription factor 1 | 0.032956 |
| OGA | O-GlcNAcase | 0.0326878 |
| FOXJ3 | forkhead box J3 | 0.0326233 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0323231 |
| APP | amyloid beta (A4) precursor protein | 0.0318785 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0318433 |
| TPR | translocated promoter region, nuclear basket protein | 0.0315962 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0315821 |
| SETD5 | SET domain containing 5 | 0.0315615 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0315444 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0313896 |
| ARFGEF3 | ARFGEF family member 3 | 0.0313864 |
| CALD1 | caldesmon 1 | 0.0311475 |
| VGLL4 | vestigial-like family member 4 | 0.0308732 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0307122 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0304189 |
| ANKZF1 | ankyrin repeat and zinc finger domain containing 1 | 0.0299359 |
| CEP250 | centrosomal protein 250kDa | 0.0298804 |
| H1-4 | H1.4 linker histone, cluster member | 0.0298666 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0297555 |
| ZNF292 | zinc finger protein 292 | 0.0296851 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0295961 |
| ZNF638 | zinc finger protein 638 | 0.0295273 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.292206 |
| FN1 | fibronectin 1 | -0.276085 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.135061 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.135027 |
| UBC | ubiquitin C | -0.108045 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0991672 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0706099 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0664583 |
| IER3 | immediate early response 3 | -0.0615629 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0614617 |
| NPR2 | natriuretic peptide receptor 2 | -0.0610835 |
| EGR1 | early growth response 1 | -0.0538087 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0509403 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0506455 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0505186 |
| CALU | calumenin | -0.0488736 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0488303 |
| JUN | jun proto-oncogene | -0.0473482 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0471328 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0453359 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0449408 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0422596 |
| CANX | calnexin | -0.0421315 |
| EMP1 | epithelial membrane protein 1 | -0.0388955 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0380956 |
| NLGN1 | neuroligin 1 | -0.0378623 |
| S100A6 | S100 calcium binding protein A6 | -0.0361065 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0360641 |
| RHEB | Ras homolog enriched in brain | -0.0357809 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0351626 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.034443 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.034426 |
| RYBP | RING1 and YY1 binding protein | -0.0342418 |
| GDF15 | growth differentiation factor 15 | -0.0340857 |
| ENO1 | enolase 1, (alpha) | -0.0331972 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0329538 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0324865 |
| VCL | vinculin | -0.0324149 |
| LRRC23 | leucine rich repeat containing 23 | -0.03203 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0319602 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0317009 |
| TMEM123 | transmembrane protein 123 | -0.031275 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0309167 |
| CLIC4 | chloride intracellular channel 4 | -0.0304209 |
| SEC24A | SEC24 family member A | -0.0303289 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0296306 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0292292 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0286218 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0280751 |
| TMEM263 | transmembrane protein 263 | -0.0272352 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0272111 |
| VMP1 | vacuole membrane protein 1 | -0.0270168 |
| DPYD | dihydropyrimidine dehydrogenase | -0.026634 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0263406 |
| TLE4 | transducin-like enhancer of split 4 | -0.0260463 |
| ATF6 | activating transcription factor 6 | -0.0259412 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0259257 |
| PCDH7 | protocadherin 7 | -0.0257689 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0252918 |
| PCBP2 | poly(rC) binding protein 2 | -0.0251493 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0249922 |
| FRMD5 | FERM domain containing 5 | -0.0249459 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.0241771 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.024064 |
| ERBIN | erbb2 interacting protein | -0.0239736 |
| MYO1E | myosin IE | -0.023966 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0238397 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0237907 |
| DIAPH2 | diaphanous-related formin 2 | -0.0236644 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | -0.0235952 |
| LDHA | lactate dehydrogenase A | -0.0235913 |
| INTS6 | integrator complex subunit 6 | -0.0234393 |
| SETX | senataxin | -0.0228691 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0225439 |
| MACROD2 | MACRO domain containing 2 | -0.0224164 |
| CCND1 | cyclin D1 | -0.0218634 |
| RCAN1 | regulator of calcineurin 1 | -0.0216648 |
| EHBP1 | EH domain binding protein 1 | -0.0215187 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0215052 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0214622 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0212756 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.0212421 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0211577 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | -0.0211134 |
| HBP1 | HMG-box transcription factor 1 | -0.0206475 |
| AHNAK | AHNAK nucleoprotein | -0.0204212 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0202583 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0201694 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0200246 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0196092 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0194292 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0194041 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0193805 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0193735 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0193671 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0193596 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -0.0192496 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0192431 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0191668 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.019108 |
