| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.145366 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.134128 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.104937 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.102794 |
| HLA-A | major histocompatibility complex, class I, A | 0.0982582 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0855093 |
| HLA-B | major histocompatibility complex, class I, B | 0.0839634 |
| TGM2 | transglutaminase 2 | 0.0836319 |
| PGK1 | phosphoglycerate kinase 1 | 0.0815778 |
| NDRG1 | N-myc downstream regulated 1 | 0.0784677 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0781146 |
| FAM13A | family with sequence similarity 13, member A | 0.07684 |
| CCNY | cyclin Y | 0.0753742 |
| PTMA | prothymosin, alpha | 0.0744698 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0742477 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0733565 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0686405 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0637573 |
| VEGFA | vascular endothelial growth factor A | 0.0608719 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0597747 |
| MCL1 | myeloid cell leukemia 1 | 0.0577943 |
| PLEC | plectin | 0.0577211 |
| RPL23 | ribosomal protein L23 | 0.0575746 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0575311 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.05684 |
| HSPA8 | heat shock 70kDa protein 8 | 0.055074 |
| ANXA11 | annexin A11 | 0.0543231 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0535607 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0533143 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0532702 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0518969 |
| AGRN | agrin | 0.051549 |
| FLNB | filamin B, beta | 0.0511366 |
| HPCAL1 | hippocalcin-like 1 | 0.0482268 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0480729 |
| EZR | ezrin | 0.0463761 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0459154 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0458466 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0454583 |
| TPM3 | tropomyosin 3 | 0.0437178 |
| HELZ | helicase with zinc finger | 0.0435314 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0432971 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0431961 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0431116 |
| APOL2 | apolipoprotein L, 2 | 0.0427946 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0427943 |
| HLA-C | major histocompatibility complex, class I, C | 0.0426673 |
| TMEM51 | transmembrane protein 51 | 0.0415801 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0412403 |
| KRT8 | keratin 8, type II | 0.0411429 |
| PCBP2 | poly(rC) binding protein 2 | 0.0403689 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.040116 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0399987 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0398568 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0397321 |
| RAD51B | RAD51 paralog B | 0.0394264 |
| OGA | O-GlcNAcase | 0.039094 |
| TMSB4X | thymosin beta 4, X-linked | 0.0387327 |
| PFKP | phosphofructokinase, platelet | 0.0384765 |
| RPL11 | ribosomal protein L11 | 0.0378038 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0377129 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0375491 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0374172 |
| RPL37A | ribosomal protein L37a | 0.0373883 |
| OPTN | optineurin | 0.0369948 |
| RPS12 | ribosomal protein S12 | 0.0368473 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0365971 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0362406 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0350015 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0348602 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0347513 |
| PRELID2 | PRELI domain containing 2 | 0.0344296 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0343755 |
| APOL1 | apolipoprotein L, 1 | 0.0340664 |
| B2M | beta-2-microglobulin | 0.0338079 |
| CMIP | c-Maf inducing protein | 0.0332677 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0328247 |
| DSTN | destrin (actin depolymerizing factor) | 0.0325865 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.032408 |
| INSIG2 | insulin induced gene 2 | 0.0324062 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0321316 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0318632 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0317648 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.031704 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0313962 |
| RPL3 | ribosomal protein L3 | 0.0313396 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0312197 |
| SMYD3 | SET and MYND domain containing 3 | 0.0311743 |
| MYOF | myoferlin | 0.0308706 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0306596 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0305706 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.030486 |
| KRT18 | keratin 18, type I | 0.03044 |
| ATXN1 | ataxin 1 | 0.0303978 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0303819 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0303191 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0301238 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0300739 |
| RPL9 | ribosomal protein L9 | 0.0298722 |
| RUNX1 | runt-related transcription factor 1 | 0.0297291 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.199393 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.193437 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.142155 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.13278 |
| MMP7 | matrix metallopeptidase 7 | -0.110037 |
| MT1X | metallothionein 1X | -0.0987897 |
| MT2A | metallothionein 2A | -0.0822341 |
| TMSB10 | thymosin beta 10 | -0.0767602 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0757942 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.075283 |
| CP | ceruloplasmin (ferroxidase) | -0.0752092 |
| KLF6 | Kruppel-like factor 6 | -0.0682346 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0660164 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.058345 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0582433 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0568419 |
| LMO7 | LIM domain 7 | -0.0541368 |
| FTL | ferritin, light polypeptide | -0.0527926 |
| HMGA1 | high mobility group AT-hook 1 | -0.0526967 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0519387 |
| ANXA2 | annexin A2 | -0.0509039 |
| LAMA4 | laminin, alpha 4 | -0.0461316 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0459456 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.045943 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0456471 |
| OSMR | oncostatin M receptor | -0.0452008 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0432187 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0415364 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0413576 |
| MYO1E | myosin IE | -0.0408566 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0408321 |
| SP100 | SP100 nuclear antigen | -0.0406908 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0406523 |
| NABP1 | nucleic acid binding protein 1 | -0.0392525 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0385939 |
| AHNAK | AHNAK nucleoprotein | -0.0378565 |
| KRT19 | keratin 19, type I | -0.0373171 |
| GNAS | GNAS complex locus | -0.0363266 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0362017 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0342978 |
| SGMS2 | sphingomyelin synthase 2 | -0.0335759 |
| DTNA | dystrobrevin, alpha | -0.0334554 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0327646 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0321827 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0310262 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0308019 |
| IER3 | immediate early response 3 | -0.0302792 |
| RPLP1 | ribosomal protein, large, P1 | -0.0299178 |
| DSG2 | desmoglein 2 | -0.0295959 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0295776 |
| CANX | calnexin | -0.0294643 |
| TJP1 | tight junction protein 1 | -0.0290923 |
| S100A6 | S100 calcium binding protein A6 | -0.0288671 |
| H1-0 | H1.0 linker histone | -0.0284916 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0281685 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0274785 |
| UBC | ubiquitin C | -0.0266284 |
| STC1 | stanniocalcin 1 | -0.0261953 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0259706 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0258326 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0256421 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0253604 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0253551 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0249605 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0249314 |
| TMEM123 | transmembrane protein 123 | -0.0246107 |
| VIM | vimentin | -0.0241351 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0233513 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0229749 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.02268 |
| LCN2 | lipocalin 2 | -0.0226466 |
| DST | dystonin | -0.0225085 |
| KYNU | kynureninase | -0.0219421 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0218527 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0218203 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0216991 |
| NRG3 | neuregulin 3 | -0.0216569 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0215536 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0215494 |
| EREG | epiregulin | -0.0215436 |
| RASAL2 | RAS protein activator like 2 | -0.0214523 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.021258 |
| S100A11 | S100 calcium binding protein A11 | -0.0212249 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.020941 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0209027 |
| MX1 | MX dynamin-like GTPase 1 | -0.020694 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0206649 |
| TFRC | transferrin receptor | -0.0204166 |
| CFB | complement factor B | -0.0202595 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.020186 |
| ARF1 | ADP-ribosylation factor 1 | -0.0199178 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0198918 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0195044 |
| JMJD1C | jumonji domain containing 1C | -0.0194732 |
| SDC4 | syndecan 4 | -0.019451 |
| PARD3 | par-3 family cell polarity regulator | -0.0194257 |
| MORF4L2 | mortality factor 4 like 2 | -0.0193657 |
| S100A10 | S100 calcium binding protein A10 | -0.0193188 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0190462 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0186113 |
