| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.152743 |
| HELZ | helicase with zinc finger | 0.124145 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.102827 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0789233 |
| MSI2 | musashi RNA-binding protein 2 | 0.0760542 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0750145 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0733666 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0723901 |
| RPS6 | ribosomal protein S6 | 0.0719905 |
| PTK2 | protein tyrosine kinase 2 | 0.0699275 |
| SETD5 | SET domain containing 5 | 0.0697746 |
| PKM | pyruvate kinase, muscle | 0.0676003 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0674025 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0660112 |
| ZNF292 | zinc finger protein 292 | 0.0652353 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0646096 |
| RPL23 | ribosomal protein L23 | 0.0639863 |
| SEPTIN9 | septin 9 | 0.0638767 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0637025 |
| PCBP2 | poly(rC) binding protein 2 | 0.0612192 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0594855 |
| WDR43 | WD repeat domain 43 | 0.0580077 |
| ENAH | enabled homolog (Drosophila) | 0.0577782 |
| PTMA | prothymosin, alpha | 0.0572849 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0570599 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0565548 |
| MEIS2 | Meis homeobox 2 | 0.0561548 |
| CCNY | cyclin Y | 0.0548207 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0547612 |
| RNF145 | ring finger protein 145 | 0.0543763 |
| MEF2A | myocyte enhancer factor 2A | 0.0536605 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0522283 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0521134 |
| LPIN1 | lipin 1 | 0.0506644 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0496977 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0489918 |
| COL1A1 | collagen, type I, alpha 1 | 0.0489879 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0487623 |
| RPS12 | ribosomal protein S12 | 0.0486415 |
| NDRG1 | N-myc downstream regulated 1 | 0.0485628 |
| QKI | QKI, KH domain containing, RNA binding | 0.0478234 |
| RPL37A | ribosomal protein L37a | 0.047597 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0465904 |
| TLK2 | tousled-like kinase 2 | 0.0465142 |
| XPO1 | exportin 1 | 0.0460161 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0459875 |
| MED13 | mediator complex subunit 13 | 0.0454352 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0452863 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0452458 |
| ZNF148 | zinc finger protein 148 | 0.0448543 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0448137 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0445069 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0437512 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0434031 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.043199 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0426923 |
| BBX | bobby sox homolog (Drosophila) | 0.0426702 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0426565 |
| RPL19 | ribosomal protein L19 | 0.0424765 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0424313 |
| TLE4 | transducin-like enhancer of split 4 | 0.0419773 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0415523 |
| VEGFA | vascular endothelial growth factor A | 0.0413202 |
| CADM1 | cell adhesion molecule 1 | 0.0412067 |
| MED13L | mediator complex subunit 13-like | 0.0408156 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0402875 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0402419 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0402285 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0402246 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0401253 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.039694 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0392913 |
| CASC3 | cancer susceptibility candidate 3 | 0.0391699 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0388846 |
| PGK1 | phosphoglycerate kinase 1 | 0.0388183 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0386904 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.038613 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0385283 |
| SNX13 | sorting nexin 13 | 0.0379541 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0378332 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0377838 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0376977 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0369566 |
| RPS3 | ribosomal protein S3 | 0.0369534 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0368779 |
| PCNX1 | pecanex 1 | 0.0364812 |
| SBF2 | SET binding factor 2 | 0.0364065 |
| YEATS2 | YEATS domain containing 2 | 0.0363532 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0363365 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0362599 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0360049 |
| ATXN1 | ataxin 1 | 0.0359371 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0358832 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0358681 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0357328 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.035335 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0350965 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0349286 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.034838 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0347077 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.246246 |
| LSAMP | limbic system-associated membrane protein | -0.128072 |
| FMN1 | formin 1 | -0.0888736 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0780629 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0733856 |
| VCL | vinculin | -0.0640236 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0561928 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0559687 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0545871 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0540772 |
| COL3A1 | collagen, type III, alpha 1 | -0.0532234 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0515057 |
| SYT1 | synaptotagmin I | -0.0456302 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0447311 |
| GPC5 | glypican 5 | -0.0440284 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0417809 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0412589 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0410545 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0407437 |
| IGF2 | insulin-like growth factor 2 | -0.0402704 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0391555 |
| TRIB2 | tribbles pseudokinase 2 | -0.0385007 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0362439 |
| ZNF804A | zinc finger protein 804A | -0.0360441 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0349919 |
| PLAT | plasminogen activator, tissue | -0.0349519 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0343025 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0341556 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0337525 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0337181 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0335587 |
| THBS1 | thrombospondin 1 | -0.0335082 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0334968 |
| EGFR | epidermal growth factor receptor | -0.032695 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0312047 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0303551 |
| RNF213 | ring finger protein 213 | -0.0291753 |
| PHF3 | PHD finger protein 3 | -0.0291378 |
| GNAS | GNAS complex locus | -0.0284257 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0281978 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0271976 |
| CCDC47 | coiled-coil domain containing 47 | -0.0267609 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0267159 |
| NREP | neuronal regeneration related protein | -0.0257279 |
| RPLP0 | ribosomal protein, large, P0 | -0.0255003 |
| ANGPT1 | angiopoietin 1 | -0.025464 |
| ITGAV | integrin, alpha V | -0.0253241 |
| CANX | calnexin | -0.025139 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0250807 |
| NRP1 | neuropilin 1 | -0.0248946 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0246919 |
| KLF6 | Kruppel-like factor 6 | -0.0245096 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | -0.024475 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0240653 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0238672 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0236055 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.023099 |
| KLHL5 | kelch-like family member 5 | -0.0230363 |
| BPTF | bromodomain PHD finger transcription factor | -0.0229539 |
| IER3 | immediate early response 3 | -0.0228835 |
| ITGA1 | integrin, alpha 1 | -0.0226319 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0225217 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0224034 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0221679 |
| PLPP1 | phospholipid phosphatase 1 | -0.022082 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0218259 |
| STC1 | stanniocalcin 1 | -0.0212619 |
| FHIT | fragile histidine triad | -0.0212368 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0211342 |
| HAS2 | hyaluronan synthase 2 | -0.0210998 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0209488 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0208378 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0206372 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0205616 |
| RIGI | RNA sensor RIG-I | -0.0205309 |
| RPS24 | ribosomal protein S24 | -0.020394 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0201447 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0200272 |
| LMAN1 | lectin, mannose-binding, 1 | -0.019952 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0199032 |
| ASL | argininosuccinate lyase | -0.0196218 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0196013 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0195971 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0193256 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0191478 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0188991 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0187759 |
| SYNJ2 | synaptojanin 2 | -0.0185162 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0185093 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0184588 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0183588 |
| GLCCI1 | glucocorticoid induced 1 | -0.0182428 |
| VDAC1 | voltage-dependent anion channel 1 | -0.018131 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0180288 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0179925 |
| NRG1 | neuregulin 1 | -0.0179688 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0178695 |
| STK38L | serine/threonine kinase 38 like | -0.0178346 |
| PELO | pelota homolog (Drosophila) | -0.0177752 |
| EGR1 | early growth response 1 | -0.0176134 |
