| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SRRM2 | serine/arginine repetitive matrix 2 | 0.12624 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.122722 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.110167 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0876436 |
| SMAD3 | SMAD family member 3 | 0.0728326 |
| TRERF1 | transcriptional regulating factor 1 | 0.0703167 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0683866 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0630806 |
| PHF3 | PHD finger protein 3 | 0.0627289 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0617945 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0613941 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0577539 |
| VEGFA | vascular endothelial growth factor A | 0.0576469 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0554925 |
| ATXN1 | ataxin 1 | 0.0550266 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0540887 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0519095 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0517092 |
| MLPH | melanophilin | 0.0507908 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0501988 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0496827 |
| NDRG1 | N-myc downstream regulated 1 | 0.0494147 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0490253 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0486186 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.047053 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0458024 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0456361 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0456293 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0451182 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0446814 |
| NEBL | nebulette | 0.0437635 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0433677 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | 0.0432958 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0427214 |
| SFTPA2 | surfactant protein A2 | 0.0421192 |
| RPS6 | ribosomal protein S6 | 0.0418544 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.0418343 |
| PFKP | phosphofructokinase, platelet | 0.0403779 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0399897 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0397706 |
| UBAC2 | UBA domain containing 2 | 0.0396789 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0396487 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 0.0396356 |
| HELZ | helicase with zinc finger | 0.0395483 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0393083 |
| CMIP | c-Maf inducing protein | 0.0388259 |
| EFNB2 | ephrin-B2 | 0.0388124 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.038673 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0372139 |
| TUFT1 | tuftelin 1 | 0.0368837 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0366534 |
| YEATS2 | YEATS domain containing 2 | 0.0361373 |
| KIF16B | kinesin family member 16B | 0.0360215 |
| ASPH | aspartate beta-hydroxylase | 0.035962 |
| AHI1 | Abelson helper integration site 1 | 0.0349953 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0342107 |
| RNF145 | ring finger protein 145 | 0.0341679 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0339871 |
| DSPP | dentin sialophosphoprotein | 0.0339249 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0339178 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0339099 |
| PRKCA | protein kinase C, alpha | 0.0337881 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0332865 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.033139 |
| HLA-A | major histocompatibility complex, class I, A | 0.0330113 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0328151 |
| PGK1 | phosphoglycerate kinase 1 | 0.0327153 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.032255 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0319749 |
| ZNF638 | zinc finger protein 638 | 0.0319598 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0319099 |
| RUNX1 | runt-related transcription factor 1 | 0.031813 |
| ZNF148 | zinc finger protein 148 | 0.0315742 |
| FAT1 | FAT atypical cadherin 1 | 0.031535 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0314966 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0312709 |
| DNM2 | dynamin 2 | 0.0310946 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.0308511 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0307705 |
| GALK2 | galactokinase 2 | 0.0306627 |
| MYO10 | myosin X | 0.0304146 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0303843 |
| RPL21 | ribosomal protein L21 | 0.0302285 |
| PTK2 | protein tyrosine kinase 2 | 0.0302149 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0300904 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0300461 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0299372 |
| RBM26 | RNA binding motif protein 26 | 0.0295019 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0294637 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0290829 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0290689 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0290571 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0289858 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0288163 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0287565 |
| LRRC1 | leucine rich repeat containing 1 | 0.0287196 |
| HDAC4 | histone deacetylase 4 | 0.0286012 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0284671 |
| STK24 | serine/threonine kinase 24 | 0.0281055 |
| DIAPH1 | diaphanous-related formin 1 | 0.0278986 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.129057 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123821 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.1189 |
| LCN2 | lipocalin 2 | -0.110147 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0987424 |
| PTMA | prothymosin, alpha | -0.0879407 |
| EXT1 | exostosin glycosyltransferase 1 | -0.085728 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.081748 |
| SP100 | SP100 nuclear antigen | -0.080802 |
| RIGI | RNA sensor RIG-I | -0.0802186 |
| VCL | vinculin | -0.0772161 |
| XAF1 | XIAP associated factor 1 | -0.0755025 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0734515 |
| B2M | beta-2-microglobulin | -0.0728039 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0696748 |
| MX2 | MX dynamin-like GTPase 2 | -0.0689752 |
| LYZ | lysozyme | -0.0678994 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0618028 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0605974 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0592498 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0590984 |
| RNF213 | ring finger protein 213 | -0.0568654 |
| EGR1 | early growth response 1 | -0.0567031 |
| SPATA13 | spermatogenesis associated 13 | -0.053454 |
| FTL | ferritin, light polypeptide | -0.053369 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0532601 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0520462 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0502237 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0494647 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0488445 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0482767 |
| MT2A | metallothionein 2A | -0.0481015 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0469647 |
| AREG | amphiregulin | -0.0453946 |
| PLSCR1 | phospholipid scramblase 1 | -0.0453297 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0446769 |
| KLF6 | Kruppel-like factor 6 | -0.0443883 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0443011 |
| MUC20 | mucin 20, cell surface associated | -0.0420164 |
| H1-0 | H1.0 linker histone | -0.0410431 |
| HMGB1 | high mobility group box 1 | -0.040109 |
| TJP1 | tight junction protein 1 | -0.0394464 |
| INTS6 | integrator complex subunit 6 | -0.0393597 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0388048 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0386346 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0373913 |
| RPS24 | ribosomal protein S24 | -0.0368928 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0362764 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.036182 |
| H3-3B | H3.3 histone B | -0.0347941 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0346193 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0338034 |
| EPHB2 | EPH receptor B2 | -0.0335005 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0329967 |
| ARF1 | ADP-ribosylation factor 1 | -0.032478 |
| IER3 | immediate early response 3 | -0.032333 |
| MYO1E | myosin IE | -0.0322649 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0322625 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0318357 |
| MORF4L2 | mortality factor 4 like 2 | -0.0317597 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0315521 |
| MKI67 | marker of proliferation Ki-67 | -0.0310986 |
| B3GALT5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | -0.0300935 |
| ERBIN | erbb2 interacting protein | -0.0299245 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0297494 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0293714 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0290602 |
| MT1X | metallothionein 1X | -0.0283991 |
| HLA-E | major histocompatibility complex, class I, E | -0.0283679 |
| PMP22 | peripheral myelin protein 22 | -0.0280096 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0278632 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0278381 |
| FHIT | fragile histidine triad | -0.0277978 |
| ABLIM1 | actin binding LIM protein 1 | -0.0277178 |
| TMEM123 | transmembrane protein 123 | -0.0276549 |
| TMSB10 | thymosin beta 10 | -0.0276394 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0274137 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0271013 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0268818 |
| MX1 | MX dynamin-like GTPase 1 | -0.0268424 |
| TMC5 | transmembrane channel-like 5 | -0.0267754 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0263888 |
| GNAS | GNAS complex locus | -0.0262223 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0261507 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0260311 |
| TMEM62 | transmembrane protein 62 | -0.0260124 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0257631 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0257145 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0254837 |
| POMP | proteasome maturation protein | -0.0252765 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0249643 |
| JUN | jun proto-oncogene | -0.0244262 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0243697 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0243383 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0242523 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0242045 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0241487 |
| BRCA2 | breast cancer 2, early onset | -0.0241283 |
| RPL35A | ribosomal protein L35a | -0.0240211 |
| ANXA1 | annexin A1 | -0.0235925 |
