| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.201649 |
| FAM13A | family with sequence similarity 13, member A | 0.148913 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.119254 |
| TMSB10 | thymosin beta 10 | 0.108605 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0978581 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0898109 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0807865 |
| HELZ | helicase with zinc finger | 0.0769222 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0737291 |
| PGK1 | phosphoglycerate kinase 1 | 0.0731675 |
| FNIP1 | folliculin interacting protein 1 | 0.0692489 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0691316 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.064484 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.059347 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0593104 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.056318 |
| PTCHD4 | patched domain containing 4 | 0.0552054 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0552019 |
| CADM1 | cell adhesion molecule 1 | 0.0549935 |
| PTMA | prothymosin, alpha | 0.0548487 |
| ADM | adrenomedullin | 0.0544772 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0542674 |
| HLA-B | major histocompatibility complex, class I, B | 0.0535312 |
| RPL35A | ribosomal protein L35a | 0.0528683 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0514313 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.051033 |
| SQSTM1 | sequestosome 1 | 0.049822 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0497242 |
| SBF2 | SET binding factor 2 | 0.0493319 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0483052 |
| CD109 | CD109 molecule | 0.0478173 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0470086 |
| ZNF395 | zinc finger protein 395 | 0.0468328 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0464139 |
| OGA | O-GlcNAcase | 0.045533 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0444105 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0442823 |
| COPA | coatomer protein complex, subunit alpha | 0.0438598 |
| FTL | ferritin, light polypeptide | 0.0435137 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0432113 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0430519 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0427698 |
| INSIG2 | insulin induced gene 2 | 0.042583 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0422222 |
| TFG | TRK-fused gene | 0.0420573 |
| SETD5 | SET domain containing 5 | 0.0418855 |
| ANK2 | ankyrin 2, neuronal | 0.0409372 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0403759 |
| PMM2 | phosphomannomutase 2 | 0.0402665 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0399398 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0396138 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0394048 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0391649 |
| HLA-A | major histocompatibility complex, class I, A | 0.0390313 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0389289 |
| GOLGA4 | golgin A4 | 0.038472 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0381202 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0375938 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0374072 |
| USP3 | ubiquitin specific peptidase 3 | 0.0373597 |
| HMBOX1 | homeobox containing 1 | 0.0369183 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0363103 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0360711 |
| SRP54 | signal recognition particle 54kDa | 0.0360444 |
| RPL23 | ribosomal protein L23 | 0.0359406 |
| PRELID2 | PRELI domain containing 2 | 0.0347402 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0347219 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0345778 |
| RPL13A | ribosomal protein L13a | 0.0343943 |
| RPS8 | ribosomal protein S8 | 0.0343193 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0335047 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0334424 |
| SFXN1 | sideroflexin 1 | 0.0333475 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0330283 |
| CDK19 | cyclin-dependent kinase 19 | 0.0328778 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0324006 |
| WDR45B | WD repeat domain 45B | 0.0323305 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0322704 |
| SNX13 | sorting nexin 13 | 0.0320312 |
| HDLBP | high density lipoprotein binding protein | 0.0318355 |
| NAV2 | neuron navigator 2 | 0.031785 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0316852 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0315177 |
| TMEM39A | transmembrane protein 39A | 0.0314501 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0313608 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0313289 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0313276 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0313263 |
| SUCO | SUN domain containing ossification factor | 0.0311799 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0308989 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0306525 |
| FLNA | filamin A, alpha | 0.0305342 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0304701 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.030315 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.029857 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0298268 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0297512 |
| CALR | calreticulin | 0.0294874 |
| RPL7A | ribosomal protein L7a | 0.0294199 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0293259 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.140092 |
| CD44 | CD44 molecule (Indian blood group) | -0.137971 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.106076 |
| ASPH | aspartate beta-hydroxylase | -0.104097 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0860225 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0794626 |
| LOX | lysyl oxidase | -0.0785797 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0778911 |
| OSMR | oncostatin M receptor | -0.076612 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0718205 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0694015 |
| KYNU | kynureninase | -0.0686048 |
| STC1 | stanniocalcin 1 | -0.0639981 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0620602 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0555713 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0550815 |
| NAV3 | neuron navigator 3 | -0.0547594 |
| RTN4 | reticulon 4 | -0.0513856 |
| EGFR | epidermal growth factor receptor | -0.0504717 |
| FN1 | fibronectin 1 | -0.0476717 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0470427 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0470186 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0436352 |
| PKM | pyruvate kinase, muscle | -0.0433022 |
| RPS2 | ribosomal protein S2 | -0.0431177 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0411445 |
| MSN | moesin | -0.0403178 |
| MKI67 | marker of proliferation Ki-67 | -0.0398283 |
| GLIS3 | GLIS family zinc finger 3 | -0.0387972 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0387419 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0382459 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0371361 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0369148 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0361034 |
| MYO10 | myosin X | -0.0359244 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0338263 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0337674 |
| IL6ST | interleukin 6 signal transducer | -0.032419 |
| RPL3 | ribosomal protein L3 | -0.0319699 |
| TXNRD1 | thioredoxin reductase 1 | -0.0318529 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0312892 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.031012 |
| USP34 | ubiquitin specific peptidase 34 | -0.0307859 |
| SEPTIN9 | septin 9 | -0.0303873 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0303772 |
| VEGFC | vascular endothelial growth factor C | -0.029665 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0296475 |
| MT1X | metallothionein 1X | -0.0294566 |
| NAV1 | neuron navigator 1 | -0.0293561 |
| ERBIN | erbb2 interacting protein | -0.0291436 |
| ANO6 | anoctamin 6 | -0.0290588 |
| CLMP | CXADR-like membrane protein | -0.0289642 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0288724 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0286918 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0285621 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0283758 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0283187 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0282767 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0277394 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0277221 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0270286 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0266783 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0258306 |
| GOLGB1 | golgin B1 | -0.0252611 |
| CALD1 | caldesmon 1 | -0.025125 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0251098 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0242764 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0239363 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.023401 |
| CCND1 | cyclin D1 | -0.0232213 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0229536 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | -0.0227508 |
| NRDC | nardilysin convertase | -0.0226737 |
| TNS3 | tensin 3 | -0.0226583 |
| BPTF | bromodomain PHD finger transcription factor | -0.0223112 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0221239 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0221086 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0219614 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0219483 |
| RAI14 | retinoic acid induced 14 | -0.0215908 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | -0.0215333 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0214784 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0214752 |
| DNMBP | dynamin binding protein | -0.0214477 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0213842 |
| RUNX1 | runt-related transcription factor 1 | -0.0213072 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0211702 |
| FRMD6 | FERM domain containing 6 | -0.0209721 |
| ETV1 | ets variant 1 | -0.0208966 |
| ARHGAP31 | Rho GTPase activating protein 31 | -0.0208771 |
| SKIL | SKI-like proto-oncogene | -0.0207002 |
| TNIP3 | TNFAIP3 interacting protein 3 | -0.0205734 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | -0.0205493 |
| TJP1 | tight junction protein 1 | -0.020511 |
| COL5A2 | collagen, type V, alpha 2 | -0.0203283 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | -0.0201929 |
| LAMB1 | laminin, beta 1 | -0.0201153 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0200654 |
| NABP1 | nucleic acid binding protein 1 | -0.0200358 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0198617 |
