| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.180211 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.142819 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.1239 |
| KRT18 | keratin 18, type I | 0.1157 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.115596 |
| PGK1 | phosphoglycerate kinase 1 | 0.102323 |
| KRT8 | keratin 8, type II | 0.0994013 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0781408 |
| SON | SON DNA binding protein | 0.0735894 |
| RPL23 | ribosomal protein L23 | 0.0676167 |
| ZNF292 | zinc finger protein 292 | 0.062917 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0580995 |
| RPL35A | ribosomal protein L35a | 0.055353 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.054527 |
| CANX | calnexin | 0.0540991 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0536929 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0526597 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0518932 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.051682 |
| GANAB | glucosidase, alpha; neutral AB | 0.0515824 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0498007 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0483375 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0483046 |
| KPNB1 | karyopherin (importin) beta 1 | 0.047358 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0467166 |
| OGA | O-GlcNAcase | 0.046432 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0455357 |
| GOLGA2 | golgin A2 | 0.0455328 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.0452664 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0451459 |
| RPS6 | ribosomal protein S6 | 0.0449568 |
| RPL13A | ribosomal protein L13a | 0.0438884 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0432683 |
| GOLGA4 | golgin A4 | 0.0430252 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0417854 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0414957 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0412054 |
| ACTG1 | actin gamma 1 | 0.0410965 |
| PCBP2 | poly(rC) binding protein 2 | 0.0409957 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0401484 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0395731 |
| ENO1 | enolase 1, (alpha) | 0.0395644 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0394512 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.039313 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0391169 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0390679 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0389815 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0388293 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0386508 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0380291 |
| RRM2 | ribonucleotide reductase M2 | 0.0374641 |
| RAD51B | RAD51 paralog B | 0.0374633 |
| ZNF638 | zinc finger protein 638 | 0.0365168 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0364784 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.036366 |
| HOXB3 | homeobox B3 | 0.0362974 |
| RPL4 | ribosomal protein L4 | 0.0362544 |
| RBM25 | RNA binding motif protein 25 | 0.0360605 |
| CALR | calreticulin | 0.0359079 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0358742 |
| PER1 | period circadian clock 1 | 0.0357369 |
| PHF3 | PHD finger protein 3 | 0.0353791 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0351864 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0347326 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0346942 |
| S100A9 | S100 calcium binding protein A9 | 0.0345476 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0344037 |
| NUP58 | nucleoporin 58 | 0.0341881 |
| PHF21A | PHD finger protein 21A | 0.0340384 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0334329 |
| HDLBP | high density lipoprotein binding protein | 0.033269 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.033216 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0329717 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0327956 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0326907 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0326036 |
| FAM117B | family with sequence similarity 117, member B | 0.0322547 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0322279 |
| RAD21 | RAD21 homolog (S. pombe) | 0.032187 |
| SCARB1 | scavenger receptor class B, member 1 | 0.0321018 |
| WASF2 | WAS protein family, member 2 | 0.0320793 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0320023 |
| DIAPH3 | diaphanous-related formin 3 | 0.0319664 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0319455 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.031865 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0315566 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.031285 |
| FUS | FUS RNA binding protein | 0.0309483 |
| RPLP0 | ribosomal protein, large, P0 | 0.0309029 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0309021 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0306602 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0305564 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0305036 |
| RLF | rearranged L-myc fusion | 0.0303878 |
| TPM3 | tropomyosin 3 | 0.0303185 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0301502 |
| BRD2 | bromodomain containing 2 | 0.0301167 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0301145 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0301074 |
| MLEC | malectin | 0.0299908 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.143175 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.110581 |
| NDRG1 | N-myc downstream regulated 1 | -0.106549 |
| MCL1 | myeloid cell leukemia 1 | -0.0936739 |
| RPS2 | ribosomal protein S2 | -0.0757747 |
| AHNAK | AHNAK nucleoprotein | -0.07577 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0691704 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0644752 |
| USP34 | ubiquitin specific peptidase 34 | -0.0644071 |
| POTEF | POTE ankyrin domain family, member F | -0.0616741 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.061334 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0600419 |
| PKM | pyruvate kinase, muscle | -0.051001 |
| VCL | vinculin | -0.050875 |
| RPL3 | ribosomal protein L3 | -0.0484291 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0479768 |
| CLTC | clathrin, heavy chain (Hc) | -0.0474437 |
| TPM4 | tropomyosin 4 | -0.0451193 |
| INTS6 | integrator complex subunit 6 | -0.0443322 |
| S100A10 | S100 calcium binding protein A10 | -0.0439472 |
| FHIT | fragile histidine triad | -0.0431225 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0424353 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0413329 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0385444 |
| VMP1 | vacuole membrane protein 1 | -0.0364493 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0361361 |
| ASPH | aspartate beta-hydroxylase | -0.0359288 |
| DSPP | dentin sialophosphoprotein | -0.0355617 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0354114 |
| FAT1 | FAT atypical cadherin 1 | -0.034978 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0328399 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.032439 |
| SP100 | SP100 nuclear antigen | -0.0314294 |
| RPL37A | ribosomal protein L37a | -0.0304581 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0298172 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0297784 |
| TXNRD1 | thioredoxin reductase 1 | -0.0297052 |
| RPS18 | ribosomal protein S18 | -0.0296903 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0296419 |
| EGFR | epidermal growth factor receptor | -0.0293766 |
| WWC2 | WW and C2 domain containing 2 | -0.0286673 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0284927 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0284345 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0279997 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.027952 |
| RCOR1 | REST corepressor 1 | -0.0278097 |
| RPS17 | ribosomal protein S17 | -0.0267012 |
| SMYD3 | SET and MYND domain containing 3 | -0.0260508 |
| TUT4 | terminal uridylyl transferase 4 | -0.0259331 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0258416 |
| IPO7 | importin 7 | -0.0256145 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0251863 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0249498 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0249449 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0245466 |
| WWOX | WW domain containing oxidoreductase | -0.0242684 |
| MYO1D | myosin ID | -0.0241027 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0240705 |
| PITPNB | phosphatidylinositol transfer protein, beta | -0.0237211 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0231731 |
| RPL38 | ribosomal protein L38 | -0.0230746 |
| CCND1 | cyclin D1 | -0.0229163 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0228617 |
| ARRDC4 | arrestin domain containing 4 | -0.0228351 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0221676 |
| HMGA1 | high mobility group AT-hook 1 | -0.0220699 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0220547 |
| EPCAM | epithelial cell adhesion molecule | -0.0220286 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.021902 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0219001 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0216272 |
| CDCP1 | CUB domain containing protein 1 | -0.0214647 |
| PCDH7 | protocadherin 7 | -0.0214319 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0211893 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0211133 |
| SMAD2 | SMAD family member 2 | -0.0209329 |
| RIGI | RNA sensor RIG-I | -0.0208791 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0208627 |
| ARMH4 | armadillo like helical domain containing 4 | -0.020841 |
| MKI67 | marker of proliferation Ki-67 | -0.020822 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0207648 |
| KLF6 | Kruppel-like factor 6 | -0.0207424 |
| REEP3 | receptor accessory protein 3 | -0.0207306 |
| IGF2 | insulin-like growth factor 2 | -0.0203439 |
| RPL6 | ribosomal protein L6 | -0.020296 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0199468 |
| HMGA2 | high mobility group AT-hook 2 | -0.0199179 |
| RPL5 | ribosomal protein L5 | -0.0198351 |
| RPS27A | ribosomal protein S27a | -0.0197357 |
| SNX14 | sorting nexin 14 | -0.019735 |
| DOCK7 | dedicator of cytokinesis 7 | -0.0197016 |
| RPL7 | ribosomal protein L7 | -0.0195862 |
| PARD3 | par-3 family cell polarity regulator | -0.0194951 |
| IL6ST | interleukin 6 signal transducer | -0.0194436 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0194283 |
| RYBP | RING1 and YY1 binding protein | -0.0194152 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.0192097 |
| ANKRD36 | ankyrin repeat domain 36 | -0.0192039 |
| LRRC23 | leucine rich repeat containing 23 | -0.0191889 |
| ARF4 | ADP-ribosylation factor 4 | -0.0191387 |
