| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.130607 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.120593 |
| RPL23 | ribosomal protein L23 | 0.0994622 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0958186 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0925535 |
| ZNF292 | zinc finger protein 292 | 0.088568 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0867 |
| PRELID2 | PRELI domain containing 2 | 0.0817084 |
| PLEC | plectin | 0.0705471 |
| TMSB4X | thymosin beta 4, X-linked | 0.0697613 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0683188 |
| RPL37A | ribosomal protein L37a | 0.0666444 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0662833 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0660574 |
| GOLGA4 | golgin A4 | 0.0657621 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0655117 |
| ANKRD11 | ankyrin repeat domain 11 | 0.064633 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0633005 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0632771 |
| MACROD2 | MACRO domain containing 2 | 0.062599 |
| RPS6 | ribosomal protein S6 | 0.0625743 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0622483 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0610494 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0600332 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0598913 |
| RPL11 | ribosomal protein L11 | 0.0588078 |
| FHIT | fragile histidine triad | 0.0586994 |
| TRIM2 | tripartite motif containing 2 | 0.0583717 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0580521 |
| AFDN | afadin, adherens junction formation factor | 0.0579568 |
| RNF145 | ring finger protein 145 | 0.0573271 |
| RPL9 | ribosomal protein L9 | 0.0571961 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0556439 |
| RPS3 | ribosomal protein S3 | 0.0556127 |
| RPL31 | ribosomal protein L31 | 0.0554473 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0541869 |
| RPS8 | ribosomal protein S8 | 0.0539406 |
| RPS12 | ribosomal protein S12 | 0.0531233 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0529345 |
| FLNB | filamin B, beta | 0.052614 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0508616 |
| FLNA | filamin A, alpha | 0.0499805 |
| RPL7A | ribosomal protein L7a | 0.0499066 |
| CTBP2 | C-terminal binding protein 2 | 0.0491673 |
| KRT7 | keratin 7, type II | 0.048462 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0484617 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0482515 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0479859 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0476637 |
| RPL26 | ribosomal protein L26 | 0.0463325 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0455076 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0446368 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0445729 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0443914 |
| RPL13A | ribosomal protein L13a | 0.0443141 |
| UPP1 | uridine phosphorylase 1 | 0.0440626 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0434633 |
| ATXN1 | ataxin 1 | 0.0432928 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0430316 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0423843 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0420875 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.041817 |
| APP | amyloid beta (A4) precursor protein | 0.0417069 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0416435 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0410724 |
| B2M | beta-2-microglobulin | 0.0409464 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0409247 |
| PTK2 | protein tyrosine kinase 2 | 0.0409008 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0404589 |
| RPS29 | ribosomal protein S29 | 0.0398448 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0396187 |
| RPS27A | ribosomal protein S27a | 0.0393297 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0390746 |
| PLCB4 | phospholipase C, beta 4 | 0.0389998 |
| RPLP2 | ribosomal protein, large, P2 | 0.0385504 |
| SBF2 | SET binding factor 2 | 0.0383426 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.038167 |
| OGA | O-GlcNAcase | 0.0380239 |
| SET | SET nuclear proto-oncogene | 0.0380002 |
| RPS19 | ribosomal protein S19 | 0.0379581 |
| DNM2 | dynamin 2 | 0.0376375 |
| WWOX | WW domain containing oxidoreductase | 0.0371253 |
| MSI2 | musashi RNA-binding protein 2 | 0.0370541 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0369453 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0366747 |
| UTRN | utrophin | 0.0361775 |
| ANXA1 | annexin A1 | 0.0358923 |
| RPL5 | ribosomal protein L5 | 0.0357337 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0347963 |
| RPL34 | ribosomal protein L34 | 0.0346726 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0343631 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0337527 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0335283 |
| RPL38 | ribosomal protein L38 | 0.0334821 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.03347 |
| RYK | receptor-like tyrosine kinase | 0.0334654 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0334425 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0333438 |
| LMNA | lamin A/C | 0.0331651 |
| SETD5 | SET domain containing 5 | 0.0330816 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.210764 |
| MT2A | metallothionein 2A | -0.0949114 |
| POTEF | POTE ankyrin domain family, member F | -0.0818681 |
| MKI67 | marker of proliferation Ki-67 | -0.0790882 |
| TXNRD1 | thioredoxin reductase 1 | -0.0778717 |
| CCND1 | cyclin D1 | -0.0742098 |
| ENO1 | enolase 1, (alpha) | -0.0728654 |
| TPM4 | tropomyosin 4 | -0.071763 |
| PKM | pyruvate kinase, muscle | -0.0669971 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0647119 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0626767 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.060511 |
| CD44 | CD44 molecule (Indian blood group) | -0.0573315 |
| LDHA | lactate dehydrogenase A | -0.0564537 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0554945 |
| LAMC2 | laminin, gamma 2 | -0.0544059 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0526371 |
| TMSB10 | thymosin beta 10 | -0.0501559 |
| VCL | vinculin | -0.0494083 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0468325 |
| EGR1 | early growth response 1 | -0.0457813 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.04305 |
| TUBB | tubulin, beta class I | -0.0425682 |
| ITGB8 | integrin, beta 8 | -0.0425152 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0423884 |
| HMGA2 | high mobility group AT-hook 2 | -0.0422633 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0411332 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0408907 |
| DIAPH3 | diaphanous-related formin 3 | -0.0401904 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0385062 |
| ASPH | aspartate beta-hydroxylase | -0.0372348 |
| LAMA4 | laminin, alpha 4 | -0.0372282 |
| ANLN | anillin, actin binding protein | -0.0368099 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0356082 |
| HMGA1 | high mobility group AT-hook 1 | -0.0354968 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0350199 |
| NF1 | neurofibromin 1 | -0.0349047 |
| TUBA1B | tubulin, alpha 1b | -0.0347287 |
| FTL | ferritin, light polypeptide | -0.0344874 |
| ITGA6 | integrin, alpha 6 | -0.0344731 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0340325 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0333299 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0329851 |
| AHNAK | AHNAK nucleoprotein | -0.0322608 |
| TAOK1 | TAO kinase 1 | -0.0313762 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0309982 |
| PFN1 | profilin 1 | -0.030984 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0309742 |
| ECT2 | epithelial cell transforming 2 | -0.0304018 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0303027 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0296598 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0294476 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0289972 |
| HELLS | helicase, lymphoid-specific | -0.0281409 |
| CDCP1 | CUB domain containing protein 1 | -0.0280304 |
| SEPTIN10 | septin 10 | -0.0270602 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0258696 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0256849 |
| HMGB1 | high mobility group box 1 | -0.0253228 |
| AXL | AXL receptor tyrosine kinase | -0.0246165 |
| MT1X | metallothionein 1X | -0.0244958 |
| XPO1 | exportin 1 | -0.0243919 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0243547 |
| WDR45B | WD repeat domain 45B | -0.0233846 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.0229021 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | -0.0224683 |
| BRCA1 | breast cancer 1, early onset | -0.0223875 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -0.0223064 |
| BICC1 | BicC family RNA binding protein 1 | -0.0221429 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.0217719 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0215997 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0215891 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.021581 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0214523 |
| PHIP | pleckstrin homology domain interacting protein | -0.0213975 |
| VMP1 | vacuole membrane protein 1 | -0.0213412 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0209267 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0209058 |
| ATAD5 | ATPase family, AAA domain containing 5 | -0.0206344 |
| CBX3 | chromobox homolog 3 | -0.0203757 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0202381 |
| SETX | senataxin | -0.0201152 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0200207 |
| BRCA2 | breast cancer 2, early onset | -0.0200179 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0199053 |
| ANXA2 | annexin A2 | -0.0198732 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0196754 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0192463 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0191894 |
| CANX | calnexin | -0.0191887 |
| MMS22L | MMS22-like, DNA repair protein | -0.0191631 |
| YBX1 | Y box binding protein 1 | -0.0190725 |
| CLTC | clathrin, heavy chain (Hc) | -0.0189382 |
| CENPK | centromere protein K | -0.0189043 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0187388 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0186512 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0186331 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.018619 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0186106 |
| FANCL | Fanconi anemia, complementation group L | -0.0185286 |
