| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.155212 |
| VIM | vimentin | 0.140491 |
| FAM13A | family with sequence similarity 13, member A | 0.127786 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.124303 |
| NDRG1 | N-myc downstream regulated 1 | 0.0975134 |
| TMSB10 | thymosin beta 10 | 0.0946507 |
| PGK1 | phosphoglycerate kinase 1 | 0.0886734 |
| CD109 | CD109 molecule | 0.0828699 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0800228 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0740725 |
| NAV2 | neuron navigator 2 | 0.0715434 |
| SMAD3 | SMAD family member 3 | 0.0710672 |
| CDCP1 | CUB domain containing protein 1 | 0.0703212 |
| RUNX1 | runt-related transcription factor 1 | 0.0693218 |
| ZNF292 | zinc finger protein 292 | 0.0658775 |
| OGA | O-GlcNAcase | 0.0657265 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0637833 |
| RNF145 | ring finger protein 145 | 0.0619796 |
| ZNF148 | zinc finger protein 148 | 0.0597717 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0591139 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0575563 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0566149 |
| SETD5 | SET domain containing 5 | 0.0563887 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0556243 |
| ADM | adrenomedullin | 0.0554587 |
| ENO1 | enolase 1, (alpha) | 0.0539832 |
| PTK2 | protein tyrosine kinase 2 | 0.0528927 |
| BBX | bobby sox homolog (Drosophila) | 0.0526281 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0523039 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0521847 |
| PDE10A | phosphodiesterase 10A | 0.0516574 |
| GOLGA4 | golgin A4 | 0.0513215 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0498179 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0491406 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0490614 |
| RPL23 | ribosomal protein L23 | 0.0489309 |
| NGLY1 | N-glycanase 1 | 0.0482671 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0464507 |
| FLNB | filamin B, beta | 0.0460639 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0453062 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0452108 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0448454 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0445776 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0445267 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0444613 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0433703 |
| ACTG1 | actin gamma 1 | 0.0428138 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0417007 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.04113 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0409333 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0409019 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.040708 |
| RPS6 | ribosomal protein S6 | 0.0404239 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0400759 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0393812 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0392699 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0390429 |
| YEATS2 | YEATS domain containing 2 | 0.0386178 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0385678 |
| ATP13A3 | ATPase type 13A3 | 0.0381028 |
| VEGFA | vascular endothelial growth factor A | 0.0379841 |
| RPL11 | ribosomal protein L11 | 0.03795 |
| RNF24 | ring finger protein 24 | 0.0378503 |
| RPL9 | ribosomal protein L9 | 0.0375974 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0375383 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0373795 |
| CENPF | centromere protein F, 350/400kDa | 0.0373492 |
| HELZ | helicase with zinc finger | 0.0368341 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0362257 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0361624 |
| RNF149 | ring finger protein 149 | 0.0359884 |
| FOXJ3 | forkhead box J3 | 0.0358258 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0357981 |
| HLA-B | major histocompatibility complex, class I, B | 0.0356739 |
| FNIP1 | folliculin interacting protein 1 | 0.0355416 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0353149 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0347907 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0347437 |
| HPCAL1 | hippocalcin-like 1 | 0.0344112 |
| CDK19 | cyclin-dependent kinase 19 | 0.0342827 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0342447 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0341369 |
| RPS8 | ribosomal protein S8 | 0.0336862 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0334846 |
| ZFHX3 | zinc finger homeobox 3 | 0.0334249 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0334218 |
| TNS1 | tensin 1 | 0.033188 |
| ARRDC3 | arrestin domain containing 3 | 0.0327953 |
| MATR3 | matrin 3 | 0.0326825 |
| TMEM165 | transmembrane protein 165 | 0.0326206 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.031988 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0319266 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0317817 |
| RPL37A | ribosomal protein L37a | 0.0316633 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0315193 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0315051 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0314079 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0312574 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.031184 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.031176 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.239364 |
| HMGA2 | high mobility group AT-hook 2 | -0.22033 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.205123 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.166939 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144409 |
| CDH13 | cadherin 13 | -0.107807 |
| LOX | lysyl oxidase | -0.0939611 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0939056 |
| CD44 | CD44 molecule (Indian blood group) | -0.0800022 |
| COL5A1 | collagen, type V, alpha 1 | -0.075994 |
| AHNAK | AHNAK nucleoprotein | -0.0734729 |
| VCL | vinculin | -0.070556 |
| CCND1 | cyclin D1 | -0.064368 |
| GLIS3 | GLIS family zinc finger 3 | -0.0622545 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0571873 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0550027 |
| IER3 | immediate early response 3 | -0.0494139 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0490828 |
| EXT1 | exostosin glycosyltransferase 1 | -0.04368 |
| EGFR | epidermal growth factor receptor | -0.0435758 |
| CANX | calnexin | -0.0430075 |
| TENM2 | teneurin transmembrane protein 2 | -0.0427593 |
| EGR1 | early growth response 1 | -0.0424583 |
| INTS6 | integrator complex subunit 6 | -0.0422065 |
| NABP1 | nucleic acid binding protein 1 | -0.0410113 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0386721 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0377603 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0364045 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0356854 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0352095 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0350998 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0349639 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0338707 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.032184 |
| FTL | ferritin, light polypeptide | -0.0311049 |
| CLIC4 | chloride intracellular channel 4 | -0.0308866 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0301986 |
| TGFB1 | transforming growth factor, beta 1 | -0.0300368 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0292816 |
| DST | dystonin | -0.0290323 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0283687 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0274593 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0274497 |
| RRBP1 | ribosome binding protein 1 | -0.0274008 |
| STC1 | stanniocalcin 1 | -0.0254559 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0254219 |
| EFNA5 | ephrin-A5 | -0.0249506 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.024905 |
| FMN1 | formin 1 | -0.0243481 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0241925 |
| OSMR | oncostatin M receptor | -0.0233285 |
| GOLGB1 | golgin B1 | -0.023142 |
| RAI14 | retinoic acid induced 14 | -0.0225532 |
| CAVIN1 | caveolae associated protein 1 | -0.0221724 |
| ACTN1 | actinin, alpha 1 | -0.0216941 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.021611 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0213309 |
| LRRC23 | leucine rich repeat containing 23 | -0.0200513 |
| DIAPH2 | diaphanous-related formin 2 | -0.0199868 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0197302 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0196681 |
| NLK | nemo-like kinase | -0.0195702 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0189268 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0187953 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0187574 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0185127 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0177167 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0176766 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0173719 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0173252 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0172407 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0170458 |
| SETX | senataxin | -0.0169099 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0168329 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0166785 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0165901 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0163464 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.016054 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.015955 |
| AEBP2 | AE binding protein 2 | -0.0157876 |
| HM13 | histocompatibility (minor) 13 | -0.0156464 |
| PTMA | prothymosin, alpha | -0.0156325 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0153837 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0152881 |
| MORF4L2 | mortality factor 4 like 2 | -0.0150971 |
| NAV1 | neuron navigator 1 | -0.0150362 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0149773 |
| IL1B | interleukin 1, beta | -0.0146095 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0144797 |
| MAP1B | microtubule-associated protein 1B | -0.0144768 |
| GOLGA3 | golgin A3 | -0.0143026 |
| ZNF804A | zinc finger protein 804A | -0.0142521 |
| COL4A2 | collagen, type IV, alpha 2 | -0.014229 |
| FAM20C | family with sequence similarity 20, member C | -0.0142165 |
| RSU1 | Ras suppressor protein 1 | -0.0142095 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.0141286 |
| NAV3 | neuron navigator 3 | -0.014075 |
| ARF1 | ADP-ribosylation factor 1 | -0.0140295 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0140279 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.013906 |
