Irinotecan (hydrochloride)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.214021
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.123657
MYH9 myosin, heavy chain 9, non-muscle 0.116102
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.10323
COL1A2 collagen, type I, alpha 2 0.10046
TIMP3 TIMP metallopeptidase inhibitor 3 0.100035
PSD3 pleckstrin and Sec7 domain containing 3 0.0961218
ATP13A3 ATPase type 13A3 0.0890744
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0888866
VEGFA vascular endothelial growth factor A 0.0813454
TPM4 tropomyosin 4 0.0806347
ACTG1 actin gamma 1 0.0781981
FN1 fibronectin 1 0.0714048
ANKRD11 ankyrin repeat domain 11 0.06886
EIF1 eukaryotic translation initiation factor 1 0.0681048
LOXL2 lysyl oxidase-like 2 0.0678497
SMAD3 SMAD family member 3 0.0594667
GOLGA4 golgin A4 0.0555482
PLEC plectin 0.0551368
HLA-B major histocompatibility complex, class I, B 0.0539064
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0503421
TTC3 tetratricopeptide repeat domain 3 0.0491678
HLA-A major histocompatibility complex, class I, A 0.0489274
DPYSL2 dihydropyrimidinase-like 2 0.047864
HSPA8 heat shock 70kDa protein 8 0.046679
COL3A1 collagen, type III, alpha 1 0.0452913
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0447064
ADM adrenomedullin 0.0442865
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0437505
ENO1 enolase 1, (alpha) 0.0435823
IGFBP7 insulin-like growth factor binding protein 7 0.0433072
CAVIN1 caveolae associated protein 1 0.0423006
CALR calreticulin 0.0418308
LDHA lactate dehydrogenase A 0.0409765
TMSB4X thymosin beta 4, X-linked 0.0397798
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.039179
EEF2 eukaryotic translation elongation factor 2 0.0387352
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0377377
RPS3 ribosomal protein S3 0.0377214
ZBTB20 zinc finger and BTB domain containing 20 0.0366433
TRIO trio Rho guanine nucleotide exchange factor 0.0365329
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0362613
SRRM2 serine/arginine repetitive matrix 2 0.035797
CMIP c-Maf inducing protein 0.035112
RPS6 ribosomal protein S6 0.0348738
RPL30 ribosomal protein L30 0.034245
RPL11 ribosomal protein L11 0.0338621
RPS12 ribosomal protein S12 0.0338249
ZNF148 zinc finger protein 148 0.0337467
SHB Src homology 2 domain containing adaptor protein B 0.0332589
FLNA filamin A, alpha 0.0330393
PRUNE2 prune homolog 2 (Drosophila) 0.0329673
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0323538
LPP LIM domain containing preferred translocation partner in lipoma 0.0322568
CAMTA1 calmodulin binding transcription activator 1 0.0322386
PRRC2C proline-rich coiled-coil 2C 0.0318135
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0317856
RPL7 ribosomal protein L7 0.0316997
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0313588
FMNL2 formin-like 2 0.0311124
COL1A1 collagen, type I, alpha 1 0.0310632
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0308353
MATR3 matrin 3 0.0303961
JARID2 jumonji, AT rich interactive domain 2 0.0303324
RACK1 receptor for activated C kinase 1 0.0301066
TGFBI transforming growth factor, beta-induced, 68kDa 0.0298054
APP amyloid beta (A4) precursor protein 0.0297414
INSIG1 insulin induced gene 1 0.029615
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0295812
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0295668
SDC2 syndecan 2 0.0294917
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0294624
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0293481
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0292853
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0291273
TRAM2 translocation associated membrane protein 2 0.028877
GANAB glucosidase, alpha; neutral AB 0.0288191
ZMIZ1 zinc finger, MIZ-type containing 1 0.0284792
PDIA5 protein disulfide isomerase family A, member 5 0.0280758
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0279303
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0276763
RPS20 ribosomal protein S20 0.0274608
RNF145 ring finger protein 145 0.0274324
NFE2L1 nuclear factor, erythroid 2-like 1 0.0268261
OGA O-GlcNAcase 0.0265443
RPN1 ribophorin I 0.0265113
RPL23 ribosomal protein L23 0.0262774
TMF1 TATA element modulatory factor 1 0.0262365
PTK2 protein tyrosine kinase 2 0.0261887
COPA coatomer protein complex, subunit alpha 0.0261305
PDIA6 protein disulfide isomerase family A, member 6 0.0261087
ZNF292 zinc finger protein 292 0.0258894
RPL13A ribosomal protein L13a 0.0258682
DOCK5 dedicator of cytokinesis 5 0.0257726
RPL37A ribosomal protein L37a 0.0254411
AVL9 AVL9 homolog (S. cerevisiase) 0.02544
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0254379
CA12 carbonic anhydrase XII 0.0254239
RPS8 ribosomal protein S8 0.025384
ITCH itchy E3 ubiquitin protein ligase 0.0253149

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.364149
IER3 immediate early response 3 -0.13168
CD44 CD44 molecule (Indian blood group) -0.129494
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113625
CDH13 cadherin 13 -0.107661
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0978754
MT2A metallothionein 2A -0.0853062
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0813935
LOX lysyl oxidase -0.073532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.072935
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.072037
IGFBP3 insulin-like growth factor binding protein 3 -0.0678236
FNDC3B fibronectin type III domain containing 3B -0.0649132
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0614165
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0589746
HMGA2 high mobility group AT-hook 2 -0.0585821
DST dystonin -0.0559787
HDAC9 histone deacetylase 9 -0.0540351
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0533108
VIM vimentin -0.051689
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.047715
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0466166
WWTR1 WW domain containing transcription regulator 1 -0.0431735
CNTN5 contactin 5 -0.0427276
H1-0 H1.0 linker histone -0.0403119
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0385854
GLIS3 GLIS family zinc finger 3 -0.0379488
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0371529
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0369251
ELL2 elongation factor, RNA polymerase II, 2 -0.0367429
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0357011
SOD2 superoxide dismutase 2, mitochondrial -0.0346386
NALF1 NALCN channel auxiliary factor 1 -0.0345337
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0344249
COL5A1 collagen, type V, alpha 1 -0.0336296
FTH1 ferritin, heavy polypeptide 1 -0.0331146
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.032011
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0317922
MAML2 mastermind-like 2 (Drosophila) -0.0311911
NABP1 nucleic acid binding protein 1 -0.0309372
MT1X metallothionein 1X -0.0308235
CCND1 cyclin D1 -0.0302165
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0300458
EGR1 early growth response 1 -0.0297714
ZFPM2 zinc finger protein, FOG family member 2 -0.0297554
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0292894
RUNX1 runt-related transcription factor 1 -0.0288775
FTL ferritin, light polypeptide -0.0284509
CLIC4 chloride intracellular channel 4 -0.0279488
ECE1 endothelin converting enzyme 1 -0.0277808
F3 coagulation factor III (thromboplastin, tissue factor) -0.0274714
HMGA1 high mobility group AT-hook 1 -0.0274374
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0273834
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0272284
ABI3BP ABI family, member 3 (NESH) binding protein -0.0271176
PDE4D phosphodiesterase 4D, cAMP-specific -0.0267436
HILPDA hypoxia inducible lipid droplet-associated -0.0265205
USP34 ubiquitin specific peptidase 34 -0.0264159
EPHB1 EPH receptor B1 -0.0263872
IL6ST interleukin 6 signal transducer -0.0261412
TSC22D2 TSC22 domain family, member 2 -0.0254927
RHEB Ras homolog enriched in brain -0.0249441
ADAM12 ADAM metallopeptidase domain 12 -0.0248114
ANLN anillin, actin binding protein -0.0246923
INHBA inhibin, beta A -0.0245577
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0245301
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0245131
TAPBP TAP binding protein (tapasin) -0.0243054
QKI QKI, KH domain containing, RNA binding -0.0241794
GLIPR1 GLI pathogenesis-related 1 -0.0241629
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0241416
S100A10 S100 calcium binding protein A10 -0.0239494
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0232642
ALCAM activated leukocyte cell adhesion molecule -0.023185
COL8A1 collagen, type VIII, alpha 1 -0.0228249
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0225225
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0224486
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0222206
ZNF207 zinc finger protein 207 -0.0218593
PTMA prothymosin, alpha -0.0217487
NAV3 neuron navigator 3 -0.0216057
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.021394
NLRP1 NLR family, pyrin domain containing 1 -0.0213383
ITGAV integrin, alpha V -0.0213267
INTS6 integrator complex subunit 6 -0.0209527
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0209275
SP100 SP100 nuclear antigen -0.0207766
HMGB1 high mobility group box 1 -0.0206637
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0206081
UBC ubiquitin C -0.0204216
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0204209
RAB7A RAB7A, member RAS oncogene family -0.0203531
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0202405
LRRC49 leucine rich repeat containing 49 -0.0196392
MX2 MX dynamin-like GTPase 2 -0.0196156
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0195423
IFIH1 interferon induced with helicase C domain 1 -0.0194896
FRMD4A FERM domain containing 4A -0.019474
FBXO11 F-box protein 11 -0.0194366
TM4SF1 transmembrane 4 L six family member 1 -0.0194006