| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT8 | keratin 8, type II | 0.194781 |
| KRT18 | keratin 18, type I | 0.130222 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.127346 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.118271 |
| ACTG1 | actin gamma 1 | 0.107567 |
| RPL23 | ribosomal protein L23 | 0.107378 |
| PLEC | plectin | 0.0956941 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0845092 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0796328 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0770354 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0744491 |
| ANXA11 | annexin A11 | 0.0734692 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0730477 |
| ATXN1 | ataxin 1 | 0.0708929 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0697095 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0639374 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0631288 |
| ACTN4 | actinin, alpha 4 | 0.062843 |
| AGRN | agrin | 0.061833 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0613286 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0602872 |
| SLC45A4 | solute carrier family 45, member 4 | 0.0583905 |
| EPS8L1 | EPS8-like 1 | 0.058321 |
| OGA | O-GlcNAcase | 0.0562539 |
| SQSTM1 | sequestosome 1 | 0.0558811 |
| VEGFA | vascular endothelial growth factor A | 0.0553728 |
| PTK2 | protein tyrosine kinase 2 | 0.0552351 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.054841 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.053735 |
| AHNAK | AHNAK nucleoprotein | 0.0533965 |
| RPL13A | ribosomal protein L13a | 0.0526748 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0521841 |
| MYO18A | myosin XVIIIA | 0.0520685 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0520573 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0515973 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0511135 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0507474 |
| HYOU1 | hypoxia up-regulated 1 | 0.0504884 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0493309 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0491428 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0480063 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0478632 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0462081 |
| GANAB | glucosidase, alpha; neutral AB | 0.0452804 |
| RBM33 | RNA binding motif protein 33 | 0.0446242 |
| RPL4 | ribosomal protein L4 | 0.0442996 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0442185 |
| PGK1 | phosphoglycerate kinase 1 | 0.0439644 |
| LAMB3 | laminin, beta 3 | 0.0439023 |
| TUFT1 | tuftelin 1 | 0.0418925 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.041273 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0411825 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0400246 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0399019 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0393481 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0393208 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0389011 |
| NFIA | nuclear factor I/A | 0.0387331 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0384449 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.038233 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0379865 |
| TPM3 | tropomyosin 3 | 0.0379392 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0379121 |
| STK24 | serine/threonine kinase 24 | 0.0377171 |
| HDGF | hepatoma-derived growth factor | 0.0369209 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0368794 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0367918 |
| HDLBP | high density lipoprotein binding protein | 0.0365609 |
| GRAMD1B | GRAM domain containing 1B | 0.0363678 |
| RPL21 | ribosomal protein L21 | 0.0358074 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0356157 |
| HLA-A | major histocompatibility complex, class I, A | 0.0354564 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0351693 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0349039 |
| RPL11 | ribosomal protein L11 | 0.0346229 |
| FLNA | filamin A, alpha | 0.0344479 |
| RPS3 | ribosomal protein S3 | 0.0343043 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0342501 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 0.0340418 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.03385 |
| RPS12 | ribosomal protein S12 | 0.0329778 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0326064 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0324009 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0323933 |
| EEIG1 | estrogen-induced osteoclastogenesis regulator 1 | 0.0319025 |
| TNS1 | tensin 1 | 0.0318103 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0317195 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0316934 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0313873 |
| BCL2L1 | BCL2-like 1 | 0.031369 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0312863 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0312466 |
| BLCAP | bladder cancer associated protein | 0.0312217 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0311836 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0311563 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0311248 |
| CCNY | cyclin Y | 0.0303014 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.0299174 |
| CALR | calreticulin | 0.029908 |
| BRD2 | bromodomain containing 2 | 0.029679 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.157931 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.129289 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101681 |
| NDRG1 | N-myc downstream regulated 1 | -0.0900838 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0839755 |
| LMO7 | LIM domain 7 | -0.0827233 |
| RPS2 | ribosomal protein S2 | -0.079493 |
| TMEM123 | transmembrane protein 123 | -0.0764879 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0759384 |
| FTL | ferritin, light polypeptide | -0.0752347 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0532337 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0522834 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0487268 |
| RPS24 | ribosomal protein S24 | -0.0466222 |
| RPLP1 | ribosomal protein, large, P1 | -0.0456765 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0436271 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.042893 |
| PDZD8 | PDZ domain containing 8 | -0.0427113 |
| RBM39 | RNA binding motif protein 39 | -0.0423636 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0418498 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0413201 |
| WWC1 | WW and C2 domain containing 1 | -0.0409782 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0408443 |
| RPL7 | ribosomal protein L7 | -0.0408345 |
| IPO7 | importin 7 | -0.0370058 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0367243 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.036437 |
| ZNF207 | zinc finger protein 207 | -0.0363742 |
| KRT20 | keratin 20, type I | -0.0355732 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0354441 |
| LIMA1 | LIM domain and actin binding 1 | -0.0353774 |
| FRY | furry homolog (Drosophila) | -0.0353184 |
| S100A10 | S100 calcium binding protein A10 | -0.0347664 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0342252 |
| CLTC | clathrin, heavy chain (Hc) | -0.0336606 |
| CD2AP | CD2-associated protein | -0.0334377 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0332353 |
| MORF4L2 | mortality factor 4 like 2 | -0.0316559 |
| CANX | calnexin | -0.031404 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0309947 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.030293 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0299187 |
| GOLGA4 | golgin A4 | -0.0298206 |
| AGR2 | anterior gradient 2 | -0.0291899 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0286777 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0282466 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0281708 |
| HMGB1 | high mobility group box 1 | -0.0267336 |
| LAMA4 | laminin, alpha 4 | -0.0267 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0266527 |
| GOLT1B | golgi transport 1B | -0.0266185 |
| MYO6 | myosin VI | -0.0265736 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.026318 |
| CLINT1 | clathrin interactor 1 | -0.0258655 |
| RAB10 | RAB10, member RAS oncogene family | -0.0255403 |
| TMC5 | transmembrane channel-like 5 | -0.0251297 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0250694 |
| MYO1E | myosin IE | -0.0248427 |
| TJP1 | tight junction protein 1 | -0.0242222 |
| PTMA | prothymosin, alpha | -0.0241839 |
| RTN3 | reticulon 3 | -0.0236065 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0235237 |
| NTN4 | netrin 4 | -0.0230748 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0230417 |
| RPS5 | ribosomal protein S5 | -0.0230043 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.0227744 |
| FOXO1 | forkhead box O1 | -0.0227499 |
| FAM135A | family with sequence similarity 135, member A | -0.0226548 |
| POF1B | premature ovarian failure, 1B | -0.0225286 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.022497 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | -0.0223133 |
| CEP350 | centrosomal protein 350kDa | -0.0215588 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0213773 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0212101 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0209122 |
| MAGT1 | magnesium transporter 1 | -0.020835 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0208156 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0205735 |
| MMP7 | matrix metallopeptidase 7 | -0.0203667 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0203573 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0202697 |
| SEC24A | SEC24 family member A | -0.0200295 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0199791 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0199192 |
| PAPOLA | poly(A) polymerase alpha | -0.0195825 |
| IFNGR1 | interferon gamma receptor 1 | -0.0195133 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0194798 |
| IL6ST | interleukin 6 signal transducer | -0.0194756 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0192109 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0191512 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0191495 |
| GPHN | gephyrin | -0.0191336 |
| ASPH | aspartate beta-hydroxylase | -0.0191021 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0190213 |
| TXNRD1 | thioredoxin reductase 1 | -0.0189982 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0189938 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0187888 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0183222 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0182683 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0182424 |
