| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.160871 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.10142 |
| C3 | complement component 3 | 0.099314 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0699748 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0697499 |
| AFDN | afadin, adherens junction formation factor | 0.0680433 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0656772 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0642103 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0632471 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0558054 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0545795 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0520735 |
| RPL3 | ribosomal protein L3 | 0.0517094 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0508162 |
| MED13L | mediator complex subunit 13-like | 0.0489776 |
| TOP1 | topoisomerase (DNA) I | 0.0473527 |
| TNS1 | tensin 1 | 0.0471709 |
| PTK2 | protein tyrosine kinase 2 | 0.0464764 |
| MSI2 | musashi RNA-binding protein 2 | 0.0451235 |
| PLEC | plectin | 0.0450026 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0449689 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0446967 |
| ZNF292 | zinc finger protein 292 | 0.0445362 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0440523 |
| RPS12 | ribosomal protein S12 | 0.0436599 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0430244 |
| SIK3 | SIK family kinase 3 | 0.0428468 |
| SVIL | supervillin | 0.0425729 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0420356 |
| KIAA1217 | KIAA1217 | 0.0415872 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0414141 |
| SMAD3 | SMAD family member 3 | 0.0412915 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0406191 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0399396 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.039734 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0396626 |
| NFIA | nuclear factor I/A | 0.0392218 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0390725 |
| CRLS1 | cardiolipin synthase 1 | 0.0386445 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0372097 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0368697 |
| CCNY | cyclin Y | 0.0363196 |
| FOXN3 | forkhead box N3 | 0.0360515 |
| RPL4 | ribosomal protein L4 | 0.0358368 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0357292 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0356246 |
| VEGFA | vascular endothelial growth factor A | 0.0355802 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0351615 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0350954 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0348405 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0348067 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0348052 |
| CMIP | c-Maf inducing protein | 0.034468 |
| PRELID2 | PRELI domain containing 2 | 0.0335915 |
| NCKAP1 | NCK-associated protein 1 | 0.0333055 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0330613 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0326964 |
| JMJD1C | jumonji domain containing 1C | 0.0326773 |
| SETD5 | SET domain containing 5 | 0.032641 |
| RBM33 | RNA binding motif protein 33 | 0.0326128 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0325476 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0318403 |
| TNRC6A | trinucleotide repeat containing 6A | 0.031818 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0316992 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0313915 |
| PDE8A | phosphodiesterase 8A | 0.0307676 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0307548 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0306516 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0305109 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0302521 |
| HLF | hepatic leukemia factor | 0.0300917 |
| TNS3 | tensin 3 | 0.0294975 |
| DENND1A | DENN/MADD domain containing 1A | 0.0294949 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0294693 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0291419 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0287798 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0286793 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0285816 |
| MYO1B | myosin IB | 0.0285564 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0284768 |
| TF | transferrin | 0.0283065 |
| OGA | O-GlcNAcase | 0.028047 |
| BRD4 | bromodomain containing 4 | 0.0280329 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0276298 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.027501 |
| RPL23 | ribosomal protein L23 | 0.0274318 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0273125 |
| RNF43 | ring finger protein 43 | 0.0272175 |
| MEIS2 | Meis homeobox 2 | 0.027001 |
| KRT8 | keratin 8, type II | 0.0266691 |
| HELZ | helicase with zinc finger | 0.0266012 |
| GSE1 | Gse1 coiled-coil protein | 0.0265665 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0262115 |
| ANO6 | anoctamin 6 | 0.026207 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.026099 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0259176 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0259087 |
| A1CF | APOBEC1 complementation factor | 0.0258258 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0258213 |
| MTSS1 | metastasis suppressor 1 | 0.02559 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.300621 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.18604 |
| MT2A | metallothionein 2A | -0.160346 |
| SLC38A2 | solute carrier family 38, member 2 | -0.142447 |
| EHBP1 | EH domain binding protein 1 | -0.119273 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.114346 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.108647 |
| GPC6 | glypican 6 | -0.0995075 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0974196 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0929796 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0887033 |
| FTL | ferritin, light polypeptide | -0.0837205 |
| DST | dystonin | -0.0823947 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0773692 |
| FN1 | fibronectin 1 | -0.075462 |
| CP | ceruloplasmin (ferroxidase) | -0.0747776 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.069754 |
| VCL | vinculin | -0.0688677 |
| ENO1 | enolase 1, (alpha) | -0.0639393 |
| AHSG | alpha-2-HS-glycoprotein | -0.0637759 |
| FRMD5 | FERM domain containing 5 | -0.0598851 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0581662 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0575096 |
| APOA2 | apolipoprotein A-II | -0.0532029 |
| TMEM123 | transmembrane protein 123 | -0.0518765 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0509513 |
| GK | glycerol kinase | -0.0486913 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0480694 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0479416 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0471314 |
| GPC3 | glypican 3 | -0.0446799 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.043898 |
| TRIM26 | tripartite motif containing 26 | -0.0429189 |
| NDRG1 | N-myc downstream regulated 1 | -0.0423089 |
| IER3 | immediate early response 3 | -0.0422772 |
| TMSB10 | thymosin beta 10 | -0.0422305 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0416624 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0415816 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0411808 |
| GNAS | GNAS complex locus | -0.0402985 |
| EGR1 | early growth response 1 | -0.0398941 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0396236 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0396037 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0386964 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.038486 |
| ASPH | aspartate beta-hydroxylase | -0.0376478 |
| CANX | calnexin | -0.0370176 |
| STK17A | serine/threonine kinase 17a | -0.0369585 |
| FAM107B | family with sequence similarity 107, member B | -0.0336595 |
| FILIP1L | filamin A interacting protein 1-like | -0.0334659 |
| TPM4 | tropomyosin 4 | -0.0334569 |
| RPS24 | ribosomal protein S24 | -0.0330123 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0330098 |
| APOE | apolipoprotein E | -0.032086 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0320203 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0314337 |
| ITGAV | integrin, alpha V | -0.0314231 |
| LOX | lysyl oxidase | -0.0310052 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0298915 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0295966 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0295897 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0295708 |
| HMGA1 | high mobility group AT-hook 1 | -0.0295504 |
| LYZ | lysozyme | -0.029215 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0288999 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0286133 |
| RPLP1 | ribosomal protein, large, P1 | -0.028484 |
| TFRC | transferrin receptor | -0.0282467 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0281274 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.027701 |
| ITGA1 | integrin, alpha 1 | -0.0276888 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0276756 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0268529 |
| NPR2 | natriuretic peptide receptor 2 | -0.0268062 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0266962 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0265969 |
| MATN3 | matrilin 3 | -0.0265762 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0262153 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0255831 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0254972 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0252409 |
| H1-0 | H1.0 linker histone | -0.0246223 |
| GDF15 | growth differentiation factor 15 | -0.0246005 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0244838 |
| MAP1B | microtubule-associated protein 1B | -0.0243198 |
| MT1X | metallothionein 1X | -0.023774 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0234779 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0234592 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0231543 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0229377 |
| NCOA7 | nuclear receptor coactivator 7 | -0.022817 |
| RYBP | RING1 and YY1 binding protein | -0.0223797 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0223136 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0223072 |
| LDHA | lactate dehydrogenase A | -0.0221762 |
| UBC | ubiquitin C | -0.0221485 |
| RPL35A | ribosomal protein L35a | -0.021967 |
| PLIN2 | perilipin 2 | -0.0218568 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0213945 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0213434 |
