| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEC | plectin | 0.163597 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.108548 |
| PGK1 | phosphoglycerate kinase 1 | 0.10763 |
| LOC112694756 | uncharaterized LOC112694756 | 0.102755 |
| BLCAP | bladder cancer associated protein | 0.0959183 |
| HLA-B | major histocompatibility complex, class I, B | 0.0948996 |
| OGA | O-GlcNAcase | 0.0919608 |
| PODXL | podocalyxin-like | 0.0917302 |
| AOPEP | aminopeptidase O (putative) | 0.0865535 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0822617 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0816132 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0763768 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0737678 |
| NAV2 | neuron navigator 2 | 0.0720036 |
| LAMA5 | laminin, alpha 5 | 0.0715676 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0695971 |
| KRT17 | keratin 17, type I | 0.0683287 |
| FLNA | filamin A, alpha | 0.0676055 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0664733 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0621561 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0606107 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0597194 |
| TMSB10 | thymosin beta 10 | 0.0595805 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0575136 |
| ANKRD11 | ankyrin repeat domain 11 | 0.056368 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0561436 |
| H1-0 | H1.0 linker histone | 0.0557517 |
| HLA-A | major histocompatibility complex, class I, A | 0.0553434 |
| RPL35A | ribosomal protein L35a | 0.0546438 |
| KIAA1217 | KIAA1217 | 0.0539114 |
| SMAD3 | SMAD family member 3 | 0.0535058 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.05151 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0510297 |
| RPL11 | ribosomal protein L11 | 0.050431 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0503899 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0503797 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0495644 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0492021 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0486106 |
| DIDO1 | death inducer-obliterator 1 | 0.0479155 |
| HLA-C | major histocompatibility complex, class I, C | 0.0474899 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0474735 |
| SQSTM1 | sequestosome 1 | 0.0455719 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0453385 |
| KRT14 | keratin 14, type I | 0.0453216 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0447808 |
| RPS6 | ribosomal protein S6 | 0.0444456 |
| RPL23 | ribosomal protein L23 | 0.0439486 |
| CEP250 | centrosomal protein 250kDa | 0.0438928 |
| EPHA2 | EPH receptor A2 | 0.0434765 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0432366 |
| TMSB4X | thymosin beta 4, X-linked | 0.0428667 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0425733 |
| GUK1 | guanylate kinase 1 | 0.0422281 |
| LMNA | lamin A/C | 0.0419848 |
| RPL13A | ribosomal protein L13a | 0.0419103 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0410092 |
| RPS21 | ribosomal protein S21 | 0.0394967 |
| TGM2 | transglutaminase 2 | 0.0392057 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0387254 |
| B2M | beta-2-microglobulin | 0.0383116 |
| PRELID2 | PRELI domain containing 2 | 0.0382985 |
| PRELID3B | PRELI domain containing 3B | 0.038259 |
| RNF145 | ring finger protein 145 | 0.0382102 |
| KRT8 | keratin 8, type II | 0.037757 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0375433 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0375357 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0373671 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0370852 |
| RPS8 | ribosomal protein S8 | 0.036408 |
| MEF2A | myocyte enhancer factor 2A | 0.0362143 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.036143 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0358197 |
| ACTN4 | actinin, alpha 4 | 0.034893 |
| RPLP2 | ribosomal protein, large, P2 | 0.0348113 |
| RPS20 | ribosomal protein S20 | 0.0343536 |
| ACTG1 | actin gamma 1 | 0.0338731 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0336226 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0334549 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0327134 |
| RPL37 | ribosomal protein L37 | 0.0320759 |
| ADM | adrenomedullin | 0.0314058 |
| APOL2 | apolipoprotein L, 2 | 0.0313619 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0313396 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0304529 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.030126 |
| RPS4X | ribosomal protein S4, X-linked | 0.0300904 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0300781 |
| RPL19 | ribosomal protein L19 | 0.0300713 |
| IRS2 | insulin receptor substrate 2 | 0.0300038 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.029765 |
| ITGB4 | integrin, beta 4 | 0.0297591 |
| RPS19 | ribosomal protein S19 | 0.0297572 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0296872 |
| RPL34 | ribosomal protein L34 | 0.0296603 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0295676 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0293258 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.029312 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0291956 |
| SLC45A4 | solute carrier family 45, member 4 | 0.029008 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.148111 |
| DPYD | dihydropyrimidine dehydrogenase | -0.142339 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.13176 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.127318 |
| NDRG1 | N-myc downstream regulated 1 | -0.124493 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.11911 |
| CUL4B | cullin 4B | -0.108399 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.101075 |
| SULF1 | sulfatase 1 | -0.0930916 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0828144 |
| RPS2 | ribosomal protein S2 | -0.0773145 |
| CANX | calnexin | -0.075971 |
| POTEF | POTE ankyrin domain family, member F | -0.070957 |
| ITGA6 | integrin, alpha 6 | -0.0682306 |
| ASPH | aspartate beta-hydroxylase | -0.0624971 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0595463 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.059513 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.058381 |
| MYOF | myoferlin | -0.0547535 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0537164 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0520943 |
| CLTC | clathrin, heavy chain (Hc) | -0.0520378 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.050302 |
| CDK6 | cyclin-dependent kinase 6 | -0.0502641 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0497806 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0496472 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0487136 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0473827 |
| OSMR | oncostatin M receptor | -0.0439992 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0420921 |
| PLAT | plasminogen activator, tissue | -0.0418572 |
| GOLGB1 | golgin B1 | -0.0411488 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0387718 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0380312 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0378977 |
| CLINT1 | clathrin interactor 1 | -0.0374554 |
| TXNRD1 | thioredoxin reductase 1 | -0.0371033 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0369551 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0353738 |
| RBM39 | RNA binding motif protein 39 | -0.0353137 |
| MSN | moesin | -0.0348765 |
| SETX | senataxin | -0.0347541 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0343066 |
| RASAL2 | RAS protein activator like 2 | -0.0333286 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0331708 |
| LAMC2 | laminin, gamma 2 | -0.0329138 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0327535 |
| IL6ST | interleukin 6 signal transducer | -0.0312654 |
| CAPRIN2 | caprin family member 2 | -0.0309269 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0308856 |
| FN1 | fibronectin 1 | -0.0307243 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0304779 |
| COG6 | component of oligomeric golgi complex 6 | -0.0302576 |
| HMGA2 | high mobility group AT-hook 2 | -0.0301934 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0297753 |
| TRAM1 | translocation associated membrane protein 1 | -0.0296319 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0290704 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0289541 |
| HM13 | histocompatibility (minor) 13 | -0.028644 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0285857 |
| MORF4L2 | mortality factor 4 like 2 | -0.0283711 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0281662 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0281548 |
| CLIC4 | chloride intracellular channel 4 | -0.0281083 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0279027 |
| MECOM | MDS1 and EVI1 complex locus | -0.027745 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0277128 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0276573 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0274621 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0273378 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.0272091 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.026787 |
| MCL1 | myeloid cell leukemia 1 | -0.0266728 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0266411 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0265621 |
| DGKH | diacylglycerol kinase, eta | -0.026426 |
| INTS6 | integrator complex subunit 6 | -0.02618 |
| EHF | ets homologous factor | -0.0259176 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0258637 |
| PAPOLA | poly(A) polymerase alpha | -0.0257981 |
| WASF2 | WAS protein family, member 2 | -0.0257836 |
| RTN4 | reticulon 4 | -0.0257084 |
| ARCN1 | archain 1 | -0.0255352 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0251023 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0249474 |
| CAV2 | caveolin 2 | -0.0249025 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0248754 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0247752 |
| RAI14 | retinoic acid induced 14 | -0.0246871 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0246815 |
| SLTM | SAFB-like, transcription modulator | -0.0244932 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0243969 |
| UTRN | utrophin | -0.0240889 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0239794 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0235065 |
| CDCP1 | CUB domain containing protein 1 | -0.0233061 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0230526 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0230351 |
| LDHA | lactate dehydrogenase A | -0.0229547 |
| ARF4 | ADP-ribosylation factor 4 | -0.0229393 |
