| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | 0.179933 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.14541 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.121735 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0952586 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0928634 |
| ZNF841 | zinc finger protein 841 | 0.0899138 |
| HLA-C | major histocompatibility complex, class I, C | 0.084141 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0788024 |
| H1-4 | H1.4 linker histone, cluster member | 0.0713197 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0689857 |
| FLNB | filamin B, beta | 0.0688407 |
| SMAD3 | SMAD family member 3 | 0.0667211 |
| NAV2 | neuron navigator 2 | 0.0659912 |
| PLEC | plectin | 0.0640476 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0590804 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0533376 |
| COL5A1 | collagen, type V, alpha 1 | 0.053293 |
| TMSB4X | thymosin beta 4, X-linked | 0.0499558 |
| HLA-A | major histocompatibility complex, class I, A | 0.0498476 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0492397 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0484821 |
| FLNA | filamin A, alpha | 0.0478214 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0473349 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0472701 |
| ADM | adrenomedullin | 0.0430879 |
| ACTG1 | actin gamma 1 | 0.0427028 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0419712 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0407373 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0395043 |
| FNIP1 | folliculin interacting protein 1 | 0.0387915 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0380656 |
| FAM219A | family with sequence similarity 219, member A | 0.037845 |
| OPTN | optineurin | 0.0370942 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0370521 |
| VEGFA | vascular endothelial growth factor A | 0.0369452 |
| YEATS2 | YEATS domain containing 2 | 0.0361187 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0360857 |
| PHACTR1 | phosphatase and actin regulator 1 | 0.0356872 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0356258 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0356102 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0354905 |
| CEP250 | centrosomal protein 250kDa | 0.0343851 |
| SEPTIN9 | septin 9 | 0.0341008 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0340625 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0336264 |
| COL7A1 | collagen, type VII, alpha 1 | 0.032846 |
| ATXN1 | ataxin 1 | 0.032368 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.031507 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.031237 |
| GOLGA2 | golgin A2 | 0.0310884 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0309233 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0306931 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0304542 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0304165 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0300151 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.029932 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0290784 |
| SQSTM1 | sequestosome 1 | 0.0290154 |
| PGK1 | phosphoglycerate kinase 1 | 0.0277579 |
| ARRDC3 | arrestin domain containing 3 | 0.0276436 |
| H1-2 | H1.2 linker histone, cluster member | 0.0275498 |
| KRT8 | keratin 8, type II | 0.0274624 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0272549 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0270014 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0266905 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0266062 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0260844 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.026023 |
| RHOA | ras homolog family member A | 0.0260153 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0255151 |
| RPL11 | ribosomal protein L11 | 0.0249582 |
| TPM3 | tropomyosin 3 | 0.0244496 |
| RAD51B | RAD51 paralog B | 0.0243687 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0241595 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0239973 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0236716 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0234302 |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.0233731 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0229902 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0228018 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0227167 |
| MYOF | myoferlin | 0.0225418 |
| KRT18 | keratin 18, type I | 0.0225353 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0223355 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0219747 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0219442 |
| SFTPA2 | surfactant protein A2 | 0.0219372 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0218563 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0218216 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0216448 |
| STC2 | stanniocalcin 2 | 0.0213518 |
| PLIN2 | perilipin 2 | 0.0212247 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0212062 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.021194 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0211317 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0210875 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0209975 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0208094 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0207688 |
| RPL3 | ribosomal protein L3 | 0.0206324 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.227815 |
| FTL | ferritin, light polypeptide | -0.227713 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.160998 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.1449 |
| MT2A | metallothionein 2A | -0.144565 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.143619 |
| ENO1 | enolase 1, (alpha) | -0.115297 |
| CD44 | CD44 molecule (Indian blood group) | -0.109444 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.103747 |
| MT1X | metallothionein 1X | -0.101365 |
| ERBIN | erbb2 interacting protein | -0.096477 |
| TXNRD1 | thioredoxin reductase 1 | -0.0950205 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0947194 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0923548 |
| EXT1 | exostosin glycosyltransferase 1 | -0.090832 |
| LDHA | lactate dehydrogenase A | -0.0777072 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0756939 |
| CANX | calnexin | -0.0752119 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0697902 |
| UBC | ubiquitin C | -0.0667948 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0659101 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0634825 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0620898 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0578672 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0563305 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0546965 |
| LMAN1 | lectin, mannose-binding, 1 | -0.054677 |
| HMGB1 | high mobility group box 1 | -0.0521752 |
| DEK | DEK proto-oncogene | -0.0521543 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0519307 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0510669 |
| IL6ST | interleukin 6 signal transducer | -0.0502673 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0498569 |
| TGFB2 | transforming growth factor, beta 2 | -0.048378 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0475313 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0465489 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.046216 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0460386 |
| IPO7 | importin 7 | -0.0460163 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.045898 |
| DIAPH3 | diaphanous-related formin 3 | -0.0457503 |
| ANXA2 | annexin A2 | -0.0451881 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0447656 |
| ARF4 | ADP-ribosylation factor 4 | -0.0447616 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0437224 |
| FN1 | fibronectin 1 | -0.0435285 |
| VIM | vimentin | -0.0428901 |
| KPNB1 | karyopherin (importin) beta 1 | -0.042824 |
| CCND1 | cyclin D1 | -0.0427278 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0413416 |
| NPPB | natriuretic peptide B | -0.0393557 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0393011 |
| NEK7 | NIMA-related kinase 7 | -0.0392933 |
| GRAMD2B | GRAM domain containing 2B | -0.0386572 |
| CUL4B | cullin 4B | -0.0386099 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.038568 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0382618 |
| TMSB10 | thymosin beta 10 | -0.0377305 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0376237 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0373001 |
| IER3 | immediate early response 3 | -0.0368351 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0367732 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0356393 |
| POTEF | POTE ankyrin domain family, member F | -0.0355886 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0354053 |
| PFN1 | profilin 1 | -0.0340302 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0336355 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.033483 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0333152 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0323241 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0320796 |
| PLCB4 | phospholipase C, beta 4 | -0.0320612 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0319333 |
| S100A10 | S100 calcium binding protein A10 | -0.0315237 |
| FOXP1 | forkhead box P1 | -0.0312334 |
| CENPF | centromere protein F, 350/400kDa | -0.0311708 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.030638 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0305466 |
| TUBA1B | tubulin, alpha 1b | -0.0298256 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0296589 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0296276 |
| MORF4L2 | mortality factor 4 like 2 | -0.0291613 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0291225 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0289843 |
| YBX1 | Y box binding protein 1 | -0.0285549 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.028507 |
| IPO5 | importin 5 | -0.0284697 |
| NOP58 | NOP58 ribonucleoprotein | -0.0282924 |
| TMEM178B | transmembrane protein 178B | -0.028275 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0279763 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0278658 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0277535 |
| PLK2 | polo-like kinase 2 | -0.0277182 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0277109 |
| LOX | lysyl oxidase | -0.0275352 |
| TLN1 | talin 1 | -0.0274166 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0273358 |
| ZNF207 | zinc finger protein 207 | -0.0270739 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0269898 |
| NF1 | neurofibromin 1 | -0.0269807 |
