| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DTNA | dystrobrevin, alpha | 0.23367 |
| RUNX1 | runt-related transcription factor 1 | 0.104059 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0907862 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0905706 |
| CD109 | CD109 molecule | 0.0890003 |
| GPC6 | glypican 6 | 0.0814249 |
| NUP58 | nucleoporin 58 | 0.0801374 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0709182 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0700544 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0694355 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0666011 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0661685 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0642666 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0635684 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0619872 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.059731 |
| RPS6 | ribosomal protein S6 | 0.0581146 |
| PGK1 | phosphoglycerate kinase 1 | 0.0570556 |
| ZNF292 | zinc finger protein 292 | 0.0566165 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.053714 |
| RNF145 | ring finger protein 145 | 0.0527129 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0501218 |
| YEATS2 | YEATS domain containing 2 | 0.0495192 |
| MED13L | mediator complex subunit 13-like | 0.0488379 |
| RPS12 | ribosomal protein S12 | 0.0477546 |
| RPL23 | ribosomal protein L23 | 0.0474917 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.047399 |
| SMYD3 | SET and MYND domain containing 3 | 0.0468567 |
| OGA | O-GlcNAcase | 0.0463842 |
| ACTG1 | actin gamma 1 | 0.0461124 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0455011 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0447896 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0446243 |
| MMP12 | matrix metallopeptidase 12 | 0.0445509 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0433884 |
| FLNA | filamin A, alpha | 0.0433122 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0432252 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0423531 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0422327 |
| RPL37A | ribosomal protein L37a | 0.0418853 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0417587 |
| SMAD3 | SMAD family member 3 | 0.039716 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0393764 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0389242 |
| PTK2 | protein tyrosine kinase 2 | 0.0388617 |
| PRELID2 | PRELI domain containing 2 | 0.0388343 |
| HELZ | helicase with zinc finger | 0.0385029 |
| ATXN1 | ataxin 1 | 0.0382938 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0382025 |
| RPL21 | ribosomal protein L21 | 0.0381465 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0380009 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0379463 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0378728 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0376695 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0375566 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.037543 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0375316 |
| MSN | moesin | 0.037076 |
| CDK19 | cyclin-dependent kinase 19 | 0.0368393 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0363463 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0359682 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0359216 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0359015 |
| PCBP2 | poly(rC) binding protein 2 | 0.0358666 |
| TPM3 | tropomyosin 3 | 0.0355339 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.035512 |
| SMAP1 | small ArfGAP 1 | 0.0355018 |
| PRKCE | protein kinase C, epsilon | 0.0350826 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.034732 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0346188 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0343438 |
| MXI1 | MAX interactor 1, dimerization protein | 0.034197 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0340418 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0337988 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0336343 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0334588 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0331548 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0331227 |
| ATP13A3 | ATPase type 13A3 | 0.0329913 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0329391 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0329085 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0326581 |
| SBF2 | SET binding factor 2 | 0.0318022 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.031646 |
| EFNA5 | ephrin-A5 | 0.0315396 |
| NCKAP1 | NCK-associated protein 1 | 0.0315039 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0314521 |
| RBM33 | RNA binding motif protein 33 | 0.0310743 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.030964 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0307864 |
| NBAS | neuroblastoma amplified sequence | 0.0307645 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.030752 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.030731 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0306999 |
| NCOR2 | nuclear receptor corepressor 2 | 0.03069 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.030675 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0306216 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0305214 |
| BBX | bobby sox homolog (Drosophila) | 0.0305171 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0303205 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.30952 |
| VIM | vimentin | -0.199281 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0851015 |
| EGR1 | early growth response 1 | -0.0846915 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0806262 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0767799 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0745597 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0724777 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0615456 |
| NABP1 | nucleic acid binding protein 1 | -0.0577038 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0563431 |
| VCL | vinculin | -0.0561561 |
| FTL | ferritin, light polypeptide | -0.0560733 |
| KYNU | kynureninase | -0.0498489 |
| CD44 | CD44 molecule (Indian blood group) | -0.0498072 |
| INTS6 | integrator complex subunit 6 | -0.047185 |
| AHNAK | AHNAK nucleoprotein | -0.047051 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0430432 |
| HMGA2 | high mobility group AT-hook 2 | -0.0420928 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0419281 |
| TMSB10 | thymosin beta 10 | -0.0404883 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0400047 |
| HDAC9 | histone deacetylase 9 | -0.0385526 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0357947 |
| RPLP0 | ribosomal protein, large, P0 | -0.0315151 |
| TNNC1 | troponin C type 1 (slow) | -0.031094 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0308164 |
| SP100 | SP100 nuclear antigen | -0.0306897 |
| PTCHD4 | patched domain containing 4 | -0.0296002 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.029161 |
| RPS24 | ribosomal protein S24 | -0.0272444 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0269878 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0268281 |
| IER3 | immediate early response 3 | -0.026565 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0262736 |
| RPLP1 | ribosomal protein, large, P1 | -0.0259785 |
| ZNF217 | zinc finger protein 217 | -0.0259061 |
| RIGI | RNA sensor RIG-I | -0.0258144 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0257505 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0256332 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0254464 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0252162 |
| ZNF804A | zinc finger protein 804A | -0.0251974 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0249573 |
| RPS25 | ribosomal protein S25 | -0.0246847 |
| JUN | jun proto-oncogene | -0.0246732 |
| RACK1 | receptor for activated C kinase 1 | -0.0240864 |
| EMP1 | epithelial membrane protein 1 | -0.0233943 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0232861 |
| HAS2 | hyaluronan synthase 2 | -0.0225253 |
| RAI14 | retinoic acid induced 14 | -0.0223672 |
| CCND1 | cyclin D1 | -0.02218 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0221272 |
| FRMD6 | FERM domain containing 6 | -0.0216565 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.021244 |
| NETO1 | neuropilin (NRP) and tolloid (TLL)-like 1 | -0.0212368 |
| IPO7 | importin 7 | -0.0209419 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0208095 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0207837 |
| CTSB | cathepsin B | -0.0207783 |
| CD163L1 | CD163 molecule-like 1 | -0.0207264 |
| LIMA1 | LIM domain and actin binding 1 | -0.0206911 |
| FOXP1 | forkhead box P1 | -0.0205308 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0204574 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0204236 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0198947 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0198182 |
| ZNF207 | zinc finger protein 207 | -0.0198154 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0197257 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0197234 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0196744 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0193992 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0190484 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0188396 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0185453 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0185337 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0184776 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0184764 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0184644 |
| RPS2 | ribosomal protein S2 | -0.0183841 |
| KLF6 | Kruppel-like factor 6 | -0.0183469 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0182757 |
| KCNQ3 | potassium channel, voltage gated KQT-like subfamily Q, member 3 | -0.0181834 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0181554 |
| TMPRSS15 | transmembrane protease, serine 15 | -0.0180758 |
| FBN2 | fibrillin 2 | -0.0180676 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0180342 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0179687 |
| ERBIN | erbb2 interacting protein | -0.0179352 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.017882 |
| INHBA | inhibin, beta A | -0.0178708 |
| MORF4L2 | mortality factor 4 like 2 | -0.0177978 |
| NTM | neurotrimin | -0.0176817 |
| RPL6 | ribosomal protein L6 | -0.0176425 |
| EFNB2 | ephrin-B2 | -0.01753 |
| FN1 | fibronectin 1 | -0.017354 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0170381 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0167847 |
| ITGA6 | integrin, alpha 6 | -0.0167587 |
| NAV3 | neuron navigator 3 | -0.0166168 |
