Irinotecan (hydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SRRM2 serine/arginine repetitive matrix 2 0.149848
KRT18 keratin 18, type I 0.121604
VEGFA vascular endothelial growth factor A 0.121581
KRT8 keratin 8, type II 0.111217
RPS6 ribosomal protein S6 0.109523
FAM13A family with sequence similarity 13, member A 0.0878628
ANKRD11 ankyrin repeat domain 11 0.0818708
EIF1 eukaryotic translation initiation factor 1 0.0804365
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0766168
HSPA8 heat shock 70kDa protein 8 0.0758692
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0689038
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0677577
DSPP dentin sialophosphoprotein 0.066945
DNM2 dynamin 2 0.0633528
PRELID2 PRELI domain containing 2 0.0622119
RPS19 ribosomal protein S19 0.0618889
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0597312
RPL37A ribosomal protein L37a 0.0592188
FAT1 FAT atypical cadherin 1 0.0580768
RPS12 ribosomal protein S12 0.0572062
PGK1 phosphoglycerate kinase 1 0.0528692
GOLGA4 golgin A4 0.0528
TPT1 tumor protein, translationally-controlled 1 0.052731
ESYT2 extended synaptotagmin-like protein 2 0.0522836
CCNY cyclin Y 0.0510199
DSCAM Down syndrome cell adhesion molecule 0.0506991
RPL7A ribosomal protein L7a 0.0492244
RPL11 ribosomal protein L11 0.0492191
NACA nascent polypeptide-associated complex alpha subunit 0.0483815
MPRIP myosin phosphatase Rho interacting protein 0.0478221
LOC112694756 uncharaterized LOC112694756 0.0476853
MYH9 myosin, heavy chain 9, non-muscle 0.0473351
TMSB4X thymosin beta 4, X-linked 0.0472163
EZR ezrin 0.0466598
GRB10 growth factor receptor-bound protein 10 0.0464699
RPL23 ribosomal protein L23 0.0463131
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0461303
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0458823
EIF4B eukaryotic translation initiation factor 4B 0.0443807
ACTG1 actin gamma 1 0.0443383
NUMA1 nuclear mitotic apparatus protein 1 0.0440255
RNF145 ring finger protein 145 0.0436262
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0432202
PRRC2C proline-rich coiled-coil 2C 0.0420273
RPL35A ribosomal protein L35a 0.0419902
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0414552
RPL13A ribosomal protein L13a 0.0413378
ATXN1 ataxin 1 0.0412994
PTEN phosphatase and tensin homolog 0.0410843
LPP LIM domain containing preferred translocation partner in lipoma 0.0409306
EEF2 eukaryotic translation elongation factor 2 0.0404235
AFF1 AF4/FMR2 family, member 1 0.0399126
AFDN afadin, adherens junction formation factor 0.0384918
NCOR2 nuclear receptor corepressor 2 0.0384771
KDM4B lysine (K)-specific demethylase 4B 0.0371394
MED13L mediator complex subunit 13-like 0.0366066
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0365223
RPL3 ribosomal protein L3 0.0357204
NUPR1 nuclear protein, transcriptional regulator, 1 0.0356952
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0355458
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0348604
RREB1 ras responsive element binding protein 1 0.0347053
ZFAND3 zinc finger, AN1-type domain 3 0.034403
KTN1 kinectin 1 (kinesin receptor) 0.0343885
PLEC plectin 0.0341358
DDIT4 DNA-damage-inducible transcript 4 0.033758
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0334054
TBC1D22A TBC1 domain family, member 22A 0.0329438
RPL21 ribosomal protein L21 0.0328474
PIGR polymeric immunoglobulin receptor 0.0327272
ANXA11 annexin A11 0.0322137
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.032143
TPM3 tropomyosin 3 0.0317926
HLA-A major histocompatibility complex, class I, A 0.0316651
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0313636
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0303606
ZNF292 zinc finger protein 292 0.0303451
CASZ1 castor zinc finger 1 0.0302088
ADD3 adducin 3 (gamma) 0.030117
KIF16B kinesin family member 16B 0.0300047
N4BP2L2 NEDD4 binding protein 2-like 2 0.0298289
EPHA2 EPH receptor A2 0.0296888
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0287902
SETD5 SET domain containing 5 0.0287372
NEBL nebulette 0.0287237
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.028536
RPL26 ribosomal protein L26 0.0282852
EIF4H eukaryotic translation initiation factor 4H 0.0281907
YTHDC1 YTH domain containing 1 0.0280772
BCLAF1 BCL2-associated transcription factor 1 0.027992
S100P S100 calcium binding protein P 0.0278667
CDK19 cyclin-dependent kinase 19 0.0276002
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0275449
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0275424
TXNIP thioredoxin interacting protein 0.027513
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.026907
RPL36 ribosomal protein L36 0.0266604
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.026349
RPS8 ribosomal protein S8 0.0262891
TNIP1 TNFAIP3 interacting protein 1 0.0262631

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.33394
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254304
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.23466
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.106707
NPSR1 neuropeptide S receptor 1 -0.089688
VCL vinculin -0.0795438
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0765529
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0631286
ASPH aspartate beta-hydroxylase -0.053058
GMDS GDP-mannose 4,6-dehydratase -0.0519442
ANTXR2 anthrax toxin receptor 2 -0.0501032
GREB1L growth regulation by estrogen in breast cancer-like -0.0460399
NALF1 NALCN channel auxiliary factor 1 -0.0449816
MYO1E myosin IE -0.0441887
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0425959
LDHA lactate dehydrogenase A -0.0423933
UBC ubiquitin C -0.0422833
ANXA2 annexin A2 -0.0412633
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0399605
RAB10 RAB10, member RAS oncogene family -0.0374035
POF1B premature ovarian failure, 1B -0.036472
CCND1 cyclin D1 -0.0361868
ENO1 enolase 1, (alpha) -0.0359459
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0350399
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0342476
PDIA4 protein disulfide isomerase family A, member 4 -0.0334473
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0312752
HMGA1 high mobility group AT-hook 1 -0.0309538
CADPS Ca++-dependent secretion activator -0.0304892
TMSB10 thymosin beta 10 -0.0299737
AREG amphiregulin -0.0295701
CLOCK clock circadian regulator -0.0290977
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0281699
ECT2 epithelial cell transforming 2 -0.0269694
S100A10 S100 calcium binding protein A10 -0.026888
RPS24 ribosomal protein S24 -0.0268684
IER3 immediate early response 3 -0.0265392
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0264702
USP53 ubiquitin specific peptidase 53 -0.0264083
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0254031
PDLIM5 PDZ and LIM domain 5 -0.0253807
GPHN gephyrin -0.0252511
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0249467
CANX calnexin -0.0247634
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0243611
FERMT1 fermitin family member 1 -0.0239376
MBNL1 muscleblind-like splicing regulator 1 -0.0238406
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0233893
RPS2 ribosomal protein S2 -0.0230816
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0229663
CLTC clathrin, heavy chain (Hc) -0.0226877
SOX9 SRY (sex determining region Y)-box 9 -0.0225911
POTEF POTE ankyrin domain family, member F -0.0225824
LAMA4 laminin, alpha 4 -0.0224788
PRSS3 protease, serine, 3 -0.0223592
AHNAK AHNAK nucleoprotein -0.0222066
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0220676
TFRC transferrin receptor -0.0220588
FTH1 ferritin, heavy polypeptide 1 -0.0218073
EFNB2 ephrin-B2 -0.0216622
PKM pyruvate kinase, muscle -0.0215264
DIAPH2 diaphanous-related formin 2 -0.0214849
NCEH1 neutral cholesterol ester hydrolase 1 -0.0205998
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0204682
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.020439
ONECUT3 one cut homeobox 3 -0.0202729
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0200948
RPS27A ribosomal protein S27a -0.0200769
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0199373
CSNK1A1 casein kinase 1, alpha 1 -0.0197967
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.019595
LOC102724023 ES1 protein homolog, mitochondrial -0.0194323
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0192701
CD44 CD44 molecule (Indian blood group) -0.0191485
RNF217 ring finger protein 217 -0.019128
NT5C2 5'-nucleotidase, cytosolic II -0.0190523
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0189364
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0189325
TMEM123 transmembrane protein 123 -0.0189291
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0184944
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0184766
PALLD palladin, cytoskeletal associated protein -0.0182534
HMGB1 high mobility group box 1 -0.0182048
NPR2 natriuretic peptide receptor 2 -0.018016
EGFR epidermal growth factor receptor -0.0179594
EHBP1 EH domain binding protein 1 -0.0179058
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0177783
ZNF207 zinc finger protein 207 -0.0175331
SLC38A1 solute carrier family 38, member 1 -0.0169488
FHIT fragile histidine triad -0.0168504
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0168418
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0167031
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0166321
CENPE centromere protein E, 312kDa -0.0163741
AGR2 anterior gradient 2 -0.0163564
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0162935
RAB1A RAB1A, member RAS oncogene family -0.0162579
MTAP methylthioadenosine phosphorylase -0.0160931
SPDYA speedy/RINGO cell cycle regulator family member A -0.015983
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0158227