| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.148379 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.133946 |
| FAT1 | FAT atypical cadherin 1 | 0.128609 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.122696 |
| KRT8 | keratin 8, type II | 0.112141 |
| PRELID2 | PRELI domain containing 2 | 0.110916 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0891733 |
| RAD51B | RAD51 paralog B | 0.0865722 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0800115 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0768013 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0767108 |
| RPL23 | ribosomal protein L23 | 0.0745512 |
| EPHA2 | EPH receptor A2 | 0.0705888 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0703188 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0680332 |
| RPL4 | ribosomal protein L4 | 0.0677147 |
| MSI2 | musashi RNA-binding protein 2 | 0.0667696 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0652466 |
| KRT18 | keratin 18, type I | 0.0635923 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0627743 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0617836 |
| FOXP1 | forkhead box P1 | 0.0614415 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0608564 |
| RPS6 | ribosomal protein S6 | 0.0596625 |
| ANXA11 | annexin A11 | 0.0592944 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0557266 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0553835 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0553345 |
| CUX1 | cut-like homeobox 1 | 0.0551542 |
| AOPEP | aminopeptidase O (putative) | 0.05378 |
| RPS12 | ribosomal protein S12 | 0.0537723 |
| RPL13A | ribosomal protein L13a | 0.052707 |
| NFIA | nuclear factor I/A | 0.0524978 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0516891 |
| HLA-B | major histocompatibility complex, class I, B | 0.0512507 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0507979 |
| DENND1A | DENN/MADD domain containing 1A | 0.0484284 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.047811 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0475826 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0474133 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0465844 |
| DSPP | dentin sialophosphoprotein | 0.0455305 |
| DNM2 | dynamin 2 | 0.0452493 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0450914 |
| ZNF292 | zinc finger protein 292 | 0.0442867 |
| SMAD3 | SMAD family member 3 | 0.0436767 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0432614 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0431603 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0426146 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0419766 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0413041 |
| CTBP2 | C-terminal binding protein 2 | 0.0408243 |
| OGA | O-GlcNAcase | 0.0401636 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0398398 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0397517 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0396931 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.038941 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0388272 |
| FAM13A | family with sequence similarity 13, member A | 0.0384909 |
| RPL3 | ribosomal protein L3 | 0.0384385 |
| ETV6 | ets variant 6 | 0.0381748 |
| AUTS2 | autism susceptibility candidate 2 | 0.0381359 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0372229 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0367834 |
| AHNAK | AHNAK nucleoprotein | 0.0362458 |
| ITGB4 | integrin, beta 4 | 0.036141 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0359166 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0349374 |
| EXOC4 | exocyst complex component 4 | 0.0348901 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0346749 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0346166 |
| HDLBP | high density lipoprotein binding protein | 0.0345319 |
| RNF213 | ring finger protein 213 | 0.0344433 |
| RBM47 | RNA binding motif protein 47 | 0.033999 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0339913 |
| SMYD3 | SET and MYND domain containing 3 | 0.0338107 |
| BCL2L1 | BCL2-like 1 | 0.0337125 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0337029 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0334806 |
| PLEC | plectin | 0.0334554 |
| PLAC8 | placenta-specific 8 | 0.0333284 |
| ASS1 | argininosuccinate synthase 1 | 0.0332365 |
| KIAA1671 | KIAA1671 | 0.0328341 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0326995 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.032264 |
| RPLP2 | ribosomal protein, large, P2 | 0.0321555 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0315715 |
| LAMB3 | laminin, beta 3 | 0.0312278 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0311638 |
| RPL37A | ribosomal protein L37a | 0.0309988 |
| ETNK1 | ethanolamine kinase 1 | 0.0305738 |
| RPS19 | ribosomal protein S19 | 0.0303673 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0300811 |
| TSPAN8 | tetraspanin 8 | 0.0296897 |
| RBM33 | RNA binding motif protein 33 | 0.0291771 |
| KIF16B | kinesin family member 16B | 0.0291344 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0289072 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0283992 |
| RPL35A | ribosomal protein L35a | 0.0281848 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0281283 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.19513 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.17173 |
| RPS2 | ribosomal protein S2 | -0.161244 |
| LMO7 | LIM domain 7 | -0.157151 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.111374 |
| TXNRD1 | thioredoxin reductase 1 | -0.108448 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.106853 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0971307 |
| POTEF | POTE ankyrin domain family, member F | -0.0727197 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0694561 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0688539 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0615762 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0606093 |
| MYO1E | myosin IE | -0.0577396 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.057298 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0569449 |
| GOLGA4 | golgin A4 | -0.0533165 |
| VCL | vinculin | -0.0524031 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0498929 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0489042 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.047096 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0439012 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0432059 |
| MYOF | myoferlin | -0.0415908 |
| CLINT1 | clathrin interactor 1 | -0.0411441 |
| CANX | calnexin | -0.0401201 |
| S100A10 | S100 calcium binding protein A10 | -0.0398253 |
| CLTC | clathrin, heavy chain (Hc) | -0.0394685 |
| ASPH | aspartate beta-hydroxylase | -0.0384214 |
| EREG | epiregulin | -0.0377748 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0370575 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.0359848 |
| RAB7A | RAB7A, member RAS oncogene family | -0.03591 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0357913 |
| ATF4 | activating transcription factor 4 | -0.0354609 |
| CLOCK | clock circadian regulator | -0.0353261 |
| SPAG9 | sperm associated antigen 9 | -0.0349507 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0340585 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0338784 |
| TJP1 | tight junction protein 1 | -0.0332456 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.033109 |
| TMSB10 | thymosin beta 10 | -0.0327277 |
| SHROOM3 | shroom family member 3 | -0.032629 |
| ANXA2 | annexin A2 | -0.0323213 |
| AREG | amphiregulin | -0.0318511 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0314341 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0313327 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0312373 |
| LDHA | lactate dehydrogenase A | -0.030492 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0301298 |
| PKM | pyruvate kinase, muscle | -0.0298095 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0290652 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0289507 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0287428 |
| OXSR1 | oxidative stress responsive 1 | -0.0284504 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0277495 |
| COG5 | component of oligomeric golgi complex 5 | -0.0274929 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.026295 |
| GOLGB1 | golgin B1 | -0.0262542 |
| GOLT1B | golgi transport 1B | -0.0259645 |
| RTN4 | reticulon 4 | -0.0258892 |
| RBM39 | RNA binding motif protein 39 | -0.0258116 |
| DSG2 | desmoglein 2 | -0.0257704 |
| TMEM263 | transmembrane protein 263 | -0.025754 |
| CCNL1 | cyclin L1 | -0.0256783 |
| CCND2 | cyclin D2 | -0.0256782 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0256038 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0253705 |
| LIMA1 | LIM domain and actin binding 1 | -0.0251093 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0250094 |
| MORF4L2 | mortality factor 4 like 2 | -0.0249989 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0248627 |
| USP53 | ubiquitin specific peptidase 53 | -0.024859 |
| PGM3 | phosphoglucomutase 3 | -0.0242081 |
| TC2N | tandem C2 domains, nuclear | -0.0237374 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0234173 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0232534 |
| EZR | ezrin | -0.0231747 |
| EPCAM | epithelial cell adhesion molecule | -0.0231521 |
| DUSP5 | dual specificity phosphatase 5 | -0.0230454 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0229481 |
| MUC13 | mucin 13, cell surface associated | -0.0229239 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0226459 |
| CCNYL1 | cyclin Y-like 1 | -0.0226279 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0226226 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0222183 |
| RPLP1 | ribosomal protein, large, P1 | -0.0221898 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.022143 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0220572 |
| PCDHB16 | protocadherin beta 16 | -0.0220366 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0217175 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0217118 |
| WWC1 | WW and C2 domain containing 1 | -0.0215754 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0214191 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.0213226 |
| SUCO | SUN domain containing ossification factor | -0.0210474 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0210246 |
| SRP54 | signal recognition particle 54kDa | -0.0209266 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.020836 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0208177 |
