Irinotecan (hydrochloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.14599
TMSB4X thymosin beta 4, X-linked 0.129615
ANKRD11 ankyrin repeat domain 11 0.122879
PGK1 phosphoglycerate kinase 1 0.105401
RPL23 ribosomal protein L23 0.102561
EIF1 eukaryotic translation initiation factor 1 0.091024
LOC112694756 uncharaterized LOC112694756 0.0858089
GARS1 glycyl-tRNA synthetase 1 0.084556
SRRM2 serine/arginine repetitive matrix 2 0.0732311
WWTR1 WW domain containing transcription regulator 1 0.066064
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0654252
WSB1 WD repeat and SOCS box containing 1 0.0651704
RPS12 ribosomal protein S12 0.0600539
YEATS2 YEATS domain containing 2 0.0593487
RPS8 ribosomal protein S8 0.0592286
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0590386
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0579153
RPL35A ribosomal protein L35a 0.0575299
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0556928
HLA-B major histocompatibility complex, class I, B 0.0540623
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0536937
RPL37A ribosomal protein L37a 0.0534018
PTK2 protein tyrosine kinase 2 0.0532525
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0521034
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0517395
RPL13A ribosomal protein L13a 0.0512015
RPS6 ribosomal protein S6 0.0511738
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.050209
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0479013
TMSB10 thymosin beta 10 0.0474677
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0468979
FLNB filamin B, beta 0.0462107
EIF4H eukaryotic translation initiation factor 4H 0.0447477
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0445652
RBM25 RNA binding motif protein 25 0.0430101
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.042875
OGA O-GlcNAcase 0.0427548
PRRC2C proline-rich coiled-coil 2C 0.041418
RPL26 ribosomal protein L26 0.041301
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0412662
PLEC plectin 0.0412285
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0408147
ZFAND3 zinc finger, AN1-type domain 3 0.0407138
DENND1A DENN/MADD domain containing 1A 0.0405786
PRRC2A proline-rich coiled-coil 2A 0.040199
PRELID2 PRELI domain containing 2 0.0400678
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0397192
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0389312
RPL37 ribosomal protein L37 0.0389153
SQSTM1 sequestosome 1 0.0387183
RPS3 ribosomal protein S3 0.0384911
KDM4B lysine (K)-specific demethylase 4B 0.0384906
PODXL podocalyxin-like 0.0383847
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0381803
PER1 period circadian clock 1 0.0376731
RPS20 ribosomal protein S20 0.0375807
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0371082
ANKRD12 ankyrin repeat domain 12 0.0370791
RPL7A ribosomal protein L7a 0.0370216
HSPA8 heat shock 70kDa protein 8 0.0369998
ZNF292 zinc finger protein 292 0.0369432
RPS19 ribosomal protein S19 0.0367897
TRERF1 transcriptional regulating factor 1 0.0365789
RPL11 ribosomal protein L11 0.0365654
ZMYND8 zinc finger, MYND-type containing 8 0.0365615
RPL28 ribosomal protein L28 0.0365461
BZW1 basic leucine zipper and W2 domains 1 0.0365308
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0363109
PABPN1 poly(A) binding protein, nuclear 1 0.0361966
RPS27A ribosomal protein S27a 0.0360289
RPL5 ribosomal protein L5 0.0356483
PYGB phosphorylase, glycogen; brain 0.0356281
RBM33 RNA binding motif protein 33 0.0354883
NIBAN2 niban apoptosis regulator 2 0.0354117
RPLP2 ribosomal protein, large, P2 0.0348777
MIDEAS mitotic deacetylase associated SANT domain protein 0.0348435
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0346043
RPL19 ribosomal protein L19 0.0345092
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.034395
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0342515
KRT18 keratin 18, type I 0.0340757
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.033728
SMYD3 SET and MYND domain containing 3 0.0335498
BCAS3 breast carcinoma amplified sequence 3 0.0332562
PNISR PNN-interacting serine/arginine-rich protein 0.0331282
SMAD3 SMAD family member 3 0.0330807
RPN1 ribophorin I 0.0325861
DLG1 discs, large homolog 1 (Drosophila) 0.0324595
APOLD1 apolipoprotein L domain containing 1 0.0324412
NACA nascent polypeptide-associated complex alpha subunit 0.0324263
RPL27 ribosomal protein L27 0.0319159
CAMTA1 calmodulin binding transcription activator 1 0.0318773
SON SON DNA binding protein 0.031731
AARS1 alanyl-tRNA synthetase 1 0.031711
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0315591
RPL9 ribosomal protein L9 0.0314951
RPL4 ribosomal protein L4 0.0312785
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0310719
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0310263
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0309551

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.171881
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148165
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.14662
ERRFI1 ERBB receptor feedback inhibitor 1 -0.122174
TP63 tumor protein p63 -0.114472
CD44 CD44 molecule (Indian blood group) -0.0992398
ZFP36L1 ZFP36 ring finger protein-like 1 -0.097413
POTEF POTE ankyrin domain family, member F -0.0966561
STAT1 signal transducer and activator of transcription 1, 91kDa -0.088218
DST dystonin -0.0866433
CANX calnexin -0.0829325
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0797563
TM4SF1 transmembrane 4 L six family member 1 -0.0689981
MT2A metallothionein 2A -0.0689141
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0674561
BIRC3 baculoviral IAP repeat containing 3 -0.0661254
ARHGAP5 Rho GTPase activating protein 5 -0.0652021
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0623751
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0617262
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0584952
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0584162
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0577319
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0576968
RPS2 ribosomal protein S2 -0.0562632
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0561692
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0559548
KMT2E lysine (K)-specific methyltransferase 2E -0.0559187
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0543583
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0520401
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0487963
DNER delta/notch-like EGF repeat containing -0.0487607
NCEH1 neutral cholesterol ester hydrolase 1 -0.0478755
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0476807
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0474995
EREG epiregulin -0.0467789
MT1X metallothionein 1X -0.0463817
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0455342
ZNF217 zinc finger protein 217 -0.0443379
BIRC2 baculoviral IAP repeat containing 2 -0.0437619
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0434911
CENPF centromere protein F, 350/400kDa -0.0427247
CFAP299 cilia and flagella associated protein 299 -0.0420579
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0415071
PLSCR1 phospholipid scramblase 1 -0.0390274
ADGRG6 adhesion G protein-coupled receptor G6 -0.0386989
SPAG9 sperm associated antigen 9 -0.0385744
IPO7 importin 7 -0.0385154
CLTC clathrin, heavy chain (Hc) -0.0382012
CDK6 cyclin-dependent kinase 6 -0.0367511
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0355287
SLC38A2 solute carrier family 38, member 2 -0.0352693
SP100 SP100 nuclear antigen -0.0345753
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0345574
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0339785
COL5A2 collagen, type V, alpha 2 -0.0335093
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0332598
VMP1 vacuole membrane protein 1 -0.0320346
MACF1 microtubule-actin crosslinking factor 1 -0.0319847
RIGI RNA sensor RIG-I -0.0316641
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0311416
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0309315
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0303954
VDAC1 voltage-dependent anion channel 1 -0.0302544
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0297352
NT5E 5'-nucleotidase, ecto (CD73) -0.0294487
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0293283
IFIH1 interferon induced with helicase C domain 1 -0.0292402
SOD2 superoxide dismutase 2, mitochondrial -0.0290906
CDCP1 CUB domain containing protein 1 -0.0287755
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0284862
RAI1 retinoic acid induced 1 -0.0281425
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0280858
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0277457
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0276301
SPIDR scaffolding protein involved in DNA repair -0.0275007
USP34 ubiquitin specific peptidase 34 -0.0274009
TXNIP thioredoxin interacting protein -0.0273924
PAPOLA poly(A) polymerase alpha -0.0270497
CUL4B cullin 4B -0.0266267
GCLM glutamate-cysteine ligase, modifier subunit -0.0263776
USP12 ubiquitin specific peptidase 12 -0.0262702
FERMT1 fermitin family member 1 -0.0257529
TSC22D2 TSC22 domain family, member 2 -0.0254801
PDE10A phosphodiesterase 10A -0.0254055
UBXN4 UBX domain protein 4 -0.0251167
MKI67 marker of proliferation Ki-67 -0.0247108
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0242964
RASAL2 RAS protein activator like 2 -0.0242304
TOR1AIP2 torsin A interacting protein 2 -0.0242198
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0238356
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0237683
DTX3L deltex 3 like, E3 ubiquitin ligase -0.0233511
PSD3 pleckstrin and Sec7 domain containing 3 -0.0232764
PLK2 polo-like kinase 2 -0.0232286
TAOK1 TAO kinase 1 -0.0229948
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0228606
SDC4 syndecan 4 -0.0228363
IFI6 interferon, alpha-inducible protein 6 -0.0227486
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0227184
UBC ubiquitin C -0.0223334