| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.219744 |
| TXNRD1 | thioredoxin reductase 1 | 0.118861 |
| PLEC | plectin | 0.11801 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.100489 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0926512 |
| LOC112694756 | uncharaterized LOC112694756 | 0.088969 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0856727 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.083078 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0792634 |
| SMAD3 | SMAD family member 3 | 0.0676671 |
| HDLBP | high density lipoprotein binding protein | 0.0606565 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.057449 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0550557 |
| FAM13A | family with sequence similarity 13, member A | 0.0550042 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0540612 |
| PGK1 | phosphoglycerate kinase 1 | 0.0491133 |
| LAMB3 | laminin, beta 3 | 0.0483896 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0476753 |
| MKI67 | marker of proliferation Ki-67 | 0.0472416 |
| RPS3 | ribosomal protein S3 | 0.0463729 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0431242 |
| RUNX1 | runt-related transcription factor 1 | 0.0425403 |
| PRRC2C | proline-rich coiled-coil 2C | 0.042124 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0420989 |
| TMEM165 | transmembrane protein 165 | 0.0417372 |
| OGA | O-GlcNAcase | 0.0404806 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0404442 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0401881 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0400448 |
| AGO2 | argonaute RISC catalytic component 2 | 0.039953 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0396921 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0395306 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0382824 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0381655 |
| YEATS2 | YEATS domain containing 2 | 0.0381645 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0367819 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0367254 |
| CPE | carboxypeptidase E | 0.0365915 |
| LAMC2 | laminin, gamma 2 | 0.0365072 |
| CTTN | cortactin | 0.0362751 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0361604 |
| SLTM | SAFB-like, transcription modulator | 0.0353997 |
| H1-0 | H1.0 linker histone | 0.0348037 |
| RPL4 | ribosomal protein L4 | 0.0347437 |
| ZNF638 | zinc finger protein 638 | 0.0347133 |
| TOP1 | topoisomerase (DNA) I | 0.0342111 |
| AHNAK | AHNAK nucleoprotein | 0.034051 |
| CES1 | carboxylesterase 1 | 0.0340084 |
| IRS2 | insulin receptor substrate 2 | 0.0339093 |
| ANO6 | anoctamin 6 | 0.0337441 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0337008 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.033682 |
| RPL3 | ribosomal protein L3 | 0.0335592 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0332483 |
| ZNF292 | zinc finger protein 292 | 0.0322298 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0320946 |
| PRELID2 | PRELI domain containing 2 | 0.0319021 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.030907 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0298744 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0296431 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0295134 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0294948 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0294853 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0291349 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0290621 |
| JAK1 | Janus kinase 1 | 0.0285671 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0284026 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0283843 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0283362 |
| SON | SON DNA binding protein | 0.0281845 |
| ADAR | adenosine deaminase, RNA-specific | 0.0279871 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0278922 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0275182 |
| PCBP2 | poly(rC) binding protein 2 | 0.0274507 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0268839 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0267877 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0264647 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.026408 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0260742 |
| RNF213 | ring finger protein 213 | 0.0259443 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0258672 |
| RNF145 | ring finger protein 145 | 0.0253879 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0253636 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0252857 |
| KIAA1217 | KIAA1217 | 0.0245365 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0244671 |
| KRT18 | keratin 18, type I | 0.0243834 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0243813 |
| SMYD3 | SET and MYND domain containing 3 | 0.0242581 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0242119 |
| TES | testin LIM domain protein | 0.0242008 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0241952 |
| TPD52 | tumor protein D52 | 0.0241898 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0241795 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0240965 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0238465 |
| RNF169 | ring finger protein 169 | 0.0236833 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0236824 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 0.0236431 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0235948 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.385767 |
| NDRG1 | N-myc downstream regulated 1 | -0.0952893 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0929309 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0878002 |
| TMSB10 | thymosin beta 10 | -0.0861341 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0760607 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0734725 |
| STC1 | stanniocalcin 1 | -0.0708555 |
| INTS6 | integrator complex subunit 6 | -0.0656938 |
| PTMA | prothymosin, alpha | -0.0655021 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0621157 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.061247 |
| ACTG1 | actin gamma 1 | -0.060898 |
| FTL | ferritin, light polypeptide | -0.0604426 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0575367 |
| EGR1 | early growth response 1 | -0.0566322 |
| S100A10 | S100 calcium binding protein A10 | -0.0564468 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.049442 |
| IER3 | immediate early response 3 | -0.0479041 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0464653 |
| NABP1 | nucleic acid binding protein 1 | -0.0454632 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0430004 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0428379 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0408377 |
| MT2A | metallothionein 2A | -0.0406583 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0400913 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0385 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0376157 |
| MORF4L2 | mortality factor 4 like 2 | -0.0361781 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0352533 |
| FBXO11 | F-box protein 11 | -0.0347868 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.034015 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0338618 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0317658 |
| AREG | amphiregulin | -0.0317445 |
| RPL35A | ribosomal protein L35a | -0.0315383 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0310363 |
| MYO1E | myosin IE | -0.0306451 |
| HMGA1 | high mobility group AT-hook 1 | -0.0304176 |
| CST3 | cystatin C | -0.0301196 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0298177 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0297785 |
| SP100 | SP100 nuclear antigen | -0.0282647 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0273766 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0271814 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0269604 |
| VCL | vinculin | -0.0268975 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0267382 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0267201 |
| MCL1 | myeloid cell leukemia 1 | -0.0265911 |
| POTEF | POTE ankyrin domain family, member F | -0.0261198 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0259669 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0256666 |
| RPLP1 | ribosomal protein, large, P1 | -0.0253776 |
| TPM4 | tropomyosin 4 | -0.0252296 |
| CDCP1 | CUB domain containing protein 1 | -0.0250983 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0249439 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0239518 |
| USP53 | ubiquitin specific peptidase 53 | -0.0238485 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0236754 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0235189 |
| SCEL | sciellin | -0.0233276 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0232407 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0229896 |
| SPAG9 | sperm associated antigen 9 | -0.022933 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0226854 |
| LDHA | lactate dehydrogenase A | -0.0224887 |
| S100A11 | S100 calcium binding protein A11 | -0.0222748 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0222648 |
| WASF2 | WAS protein family, member 2 | -0.0215284 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0214538 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.021318 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0213138 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0207749 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0203251 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0202266 |
| RPS25 | ribosomal protein S25 | -0.0201942 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0201547 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.02013 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0197562 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0197169 |
| RYBP | RING1 and YY1 binding protein | -0.0196008 |
| CCNL1 | cyclin L1 | -0.0195604 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0194316 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0191809 |
| HOMER1 | homer scaffolding protein 1 | -0.0190014 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0186184 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0186135 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0182692 |
| ATG7 | autophagy related 7 | -0.0182424 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0181535 |
| FUS | FUS RNA binding protein | -0.0181123 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0180051 |
| LMO7 | LIM domain 7 | -0.0179242 |
| CAV2 | caveolin 2 | -0.0174496 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0170284 |
| OXSR1 | oxidative stress responsive 1 | -0.016864 |
| CCNI | cyclin I | -0.0166535 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0164371 |
| MYO1D | myosin ID | -0.0163531 |
