| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.160419 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.143253 |
| GRB10 | growth factor receptor-bound protein 10 | 0.114933 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.109619 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0953227 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0877809 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.081059 |
| FAM20C | family with sequence similarity 20, member C | 0.0797928 |
| TMSB10 | thymosin beta 10 | 0.0781934 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0775287 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0680562 |
| HLA-B | major histocompatibility complex, class I, B | 0.0646946 |
| PGK1 | phosphoglycerate kinase 1 | 0.0628648 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0615761 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0613621 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0603799 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0598651 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0583047 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.058027 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0570722 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0559028 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0557582 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0555741 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0545893 |
| CALU | calumenin | 0.0513279 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0512056 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0506332 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0504859 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0502575 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0489036 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0483967 |
| VMP1 | vacuole membrane protein 1 | 0.0477657 |
| RUNX2 | runt-related transcription factor 2 | 0.0467858 |
| HDLBP | high density lipoprotein binding protein | 0.0458422 |
| CEP250 | centrosomal protein 250kDa | 0.0456651 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0454075 |
| AOPEP | aminopeptidase O (putative) | 0.0452731 |
| TMSB4X | thymosin beta 4, X-linked | 0.0436601 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0431648 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0425897 |
| SQSTM1 | sequestosome 1 | 0.0420687 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0420168 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0420001 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0414755 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0405503 |
| DNER | delta/notch-like EGF repeat containing | 0.0403308 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0399968 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0398179 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0393666 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0393487 |
| ADM | adrenomedullin | 0.0393031 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0391631 |
| NGLY1 | N-glycanase 1 | 0.0390835 |
| ACTG1 | actin gamma 1 | 0.038824 |
| HLA-A | major histocompatibility complex, class I, A | 0.0387244 |
| SETD5 | SET domain containing 5 | 0.0386113 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0383642 |
| RPL4 | ribosomal protein L4 | 0.0378817 |
| NAV2 | neuron navigator 2 | 0.0371749 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0369736 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0369365 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0369054 |
| FAM13A | family with sequence similarity 13, member A | 0.0361231 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0359542 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0353648 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0353078 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0348515 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0347989 |
| COPA | coatomer protein complex, subunit alpha | 0.0346481 |
| OPTN | optineurin | 0.0342805 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0337276 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0334304 |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 0.0332835 |
| RPL23 | ribosomal protein L23 | 0.0332354 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0331243 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0330674 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0328456 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0328074 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.0324024 |
| PFKP | phosphofructokinase, platelet | 0.0323917 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0323225 |
| DHFR | dihydrofolate reductase | 0.0321655 |
| OGA | O-GlcNAcase | 0.0320192 |
| AHNAK | AHNAK nucleoprotein | 0.0318714 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0316569 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0312608 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0312562 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.031084 |
| HLA-C | major histocompatibility complex, class I, C | 0.0307464 |
| PLIN2 | perilipin 2 | 0.0306138 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0306102 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0305131 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0302979 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0302273 |
| RPL35A | ribosomal protein L35a | 0.0298492 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0298361 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0296627 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0296159 |
| ANXA2 | annexin A2 | 0.0296118 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0294954 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.184159 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125309 |
| NDRG1 | N-myc downstream regulated 1 | -0.106957 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.101001 |
| CD44 | CD44 molecule (Indian blood group) | -0.0998218 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0886591 |
| MT2A | metallothionein 2A | -0.0829391 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0820228 |
| USP34 | ubiquitin specific peptidase 34 | -0.0785082 |
| RPS2 | ribosomal protein S2 | -0.0727856 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0720038 |
| EFNA5 | ephrin-A5 | -0.0653305 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0640888 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0579539 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0512789 |
| FTL | ferritin, light polypeptide | -0.0504019 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.049938 |
| DST | dystonin | -0.0488026 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0487374 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0433531 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0425826 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.042512 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0395523 |
| RAD51B | RAD51 paralog B | -0.0385351 |
| RBM39 | RNA binding motif protein 39 | -0.0368202 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0366495 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.036413 |
| GPC6 | glypican 6 | -0.0352409 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0344884 |
| ASPH | aspartate beta-hydroxylase | -0.0343269 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0338478 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0327823 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0322113 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0320863 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.031764 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0314352 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0309123 |
| DTNA | dystrobrevin, alpha | -0.0301007 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0299417 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.029924 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0298487 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.029754 |
| GPHN | gephyrin | -0.029411 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0289381 |
| CEP350 | centrosomal protein 350kDa | -0.0288505 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0282125 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0274114 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0274107 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0272856 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0272062 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0271528 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0265472 |
| LOX | lysyl oxidase | -0.0263754 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0261272 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0259866 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0258957 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0256841 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0254467 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0254267 |
| SYT1 | synaptotagmin I | -0.025386 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0249519 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0249073 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0248729 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0248523 |
| MYO6 | myosin VI | -0.0246397 |
| USP53 | ubiquitin specific peptidase 53 | -0.0244552 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0241901 |
| CANX | calnexin | -0.0238978 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0238547 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0235497 |
| POTEF | POTE ankyrin domain family, member F | -0.0235275 |
| CLTC | clathrin, heavy chain (Hc) | -0.0233158 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0232038 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0231365 |
| STK38L | serine/threonine kinase 38 like | -0.022747 |
| RYBP | RING1 and YY1 binding protein | -0.0227264 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0224553 |
| AADAC | arylacetamide deacetylase | -0.022308 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0220333 |
| INTS6 | integrator complex subunit 6 | -0.0219959 |
| UBXN4 | UBX domain protein 4 | -0.021574 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.021531 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0213828 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0211516 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0210208 |
| HMGA1 | high mobility group AT-hook 1 | -0.0208521 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0208497 |
| MED13 | mediator complex subunit 13 | -0.0207251 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0206481 |
| CDH13 | cadherin 13 | -0.0205551 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | -0.0205198 |
| FHL2 | four and a half LIM domains 2 | -0.020457 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0204565 |
| PHIP | pleckstrin homology domain interacting protein | -0.0202441 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0201865 |
| CFAP20DC | CFAP20 domain containing | -0.0201711 |
| JMJD1C | jumonji domain containing 1C | -0.0200245 |
| PAPOLA | poly(A) polymerase alpha | -0.0199782 |
| CDK6 | cyclin-dependent kinase 6 | -0.0199686 |
| TXNRD1 | thioredoxin reductase 1 | -0.0198218 |
