Irinotecan (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Irinotecan (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.211909
TMSB10 thymosin beta 10 0.122603
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0994553
RPL23 ribosomal protein L23 0.0818716
ANKRD11 ankyrin repeat domain 11 0.07249
FTH1 ferritin, heavy polypeptide 1 0.0720923
TPM3 tropomyosin 3 0.0669341
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0666195
FAM168A family with sequence similarity 168, member A 0.0659143
SRRM2 serine/arginine repetitive matrix 2 0.0658412
TPD52 tumor protein D52 0.0655747
HSPA8 heat shock 70kDa protein 8 0.0652671
BASP1 brain abundant, membrane attached signal protein 1 0.0642117
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0570428
USP3 ubiquitin specific peptidase 3 0.0557894
EIF1 eukaryotic translation initiation factor 1 0.0556507
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0544494
RPS20 ribosomal protein S20 0.0531335
RPL13A ribosomal protein L13a 0.0505433
ZNF292 zinc finger protein 292 0.0488296
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0487105
MACF1 microtubule-actin crosslinking factor 1 0.0484849
PTK2 protein tyrosine kinase 2 0.0475943
AKAP13 A kinase (PRKA) anchor protein 13 0.0468807
HLA-B major histocompatibility complex, class I, B 0.0462618
FLNA filamin A, alpha 0.0458857
PDE4D phosphodiesterase 4D, cAMP-specific 0.0447568
RNF145 ring finger protein 145 0.0447411
TAGLN2 transgelin 2 0.0442185
LOC112694756 uncharaterized LOC112694756 0.0436111
CALR calreticulin 0.043504
IGFBP3 insulin-like growth factor binding protein 3 0.043385
AHNAK AHNAK nucleoprotein 0.0426027
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.042579
LMNA lamin A/C 0.0416028
PRRC2A proline-rich coiled-coil 2A 0.0415957
ARHGAP12 Rho GTPase activating protein 12 0.0412475
HLA-A major histocompatibility complex, class I, A 0.0410308
ARHGAP26 Rho GTPase activating protein 26 0.0407012
MEF2D myocyte enhancer factor 2D 0.0401881
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0398986
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0396546
PGK1 phosphoglycerate kinase 1 0.0393906
ZFAND3 zinc finger, AN1-type domain 3 0.0393839
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0392409
RPS12 ribosomal protein S12 0.0384988
PABPN1 poly(A) binding protein, nuclear 1 0.0383502
JAK1 Janus kinase 1 0.0381655
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0375433
RPS21 ribosomal protein S21 0.037396
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0373573
NUMA1 nuclear mitotic apparatus protein 1 0.0372294
B2M beta-2-microglobulin 0.0369946
RPL4 ribosomal protein L4 0.0365943
PYGL phosphorylase, glycogen, liver 0.0360487
DEK DEK proto-oncogene 0.0358916
PDIA6 protein disulfide isomerase family A, member 6 0.0348448
RERE arginine-glutamic acid dipeptide (RE) repeats 0.034736
PRRC2C proline-rich coiled-coil 2C 0.0342344
PLEC plectin 0.0339245
TPI1 triosephosphate isomerase 1 0.0337825
FLNB filamin B, beta 0.0337812
LGALS1 lectin, galactoside-binding, soluble, 1 0.0337423
CAVIN1 caveolae associated protein 1 0.0333198
IQGAP1 IQ motif containing GTPase activating protein 1 0.0330977
MTMR3 myotubularin related protein 3 0.0330101
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0329369
SMOC1 SPARC related modular calcium binding 1 0.0325913
PCBP2 poly(rC) binding protein 2 0.0323505
SMAD3 SMAD family member 3 0.0322373
NACA nascent polypeptide-associated complex alpha subunit 0.0317401
HLA-C major histocompatibility complex, class I, C 0.0316492
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0315526
GANAB glucosidase, alpha; neutral AB 0.0315117
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0310018
FUS FUS RNA binding protein 0.0309645
NUP58 nucleoporin 58 0.0309168
CHN1 chimerin 1 0.0307444
MYH9 myosin, heavy chain 9, non-muscle 0.0299582
MAML3 mastermind-like 3 (Drosophila) 0.0298774
KIAA0319 KIAA0319 0.029781
RPL11 ribosomal protein L11 0.0297091
RBM25 RNA binding motif protein 25 0.0296774
TMSB4X thymosin beta 4, X-linked 0.0295615
PDE8A phosphodiesterase 8A 0.029471
RPS19 ribosomal protein S19 0.0289459
RPL36 ribosomal protein L36 0.0287291
FAM107B family with sequence similarity 107, member B 0.0286755
SFTPA2 surfactant protein A2 0.0285073
PLS3 plastin 3 0.0284093
PTMA prothymosin, alpha 0.0283918
CLU clusterin 0.0282636
SF1 splicing factor 1 0.0281345
KLF6 Kruppel-like factor 6 0.0279969
EIF4H eukaryotic translation initiation factor 4H 0.027471
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0272236
HDGF hepatoma-derived growth factor 0.0270908
NPTN neuroplastin 0.026861
NEBL nebulette 0.0268248
MAP4 microtubule-associated protein 4 0.0267365

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.231174
TXNRD1 thioredoxin reductase 1 -0.167857
MT2A metallothionein 2A -0.167533
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116997
RPS2 ribosomal protein S2 -0.0942149
TFPI2 tissue factor pathway inhibitor 2 -0.0906387
GRAMD1B GRAM domain containing 1B -0.0779488
ERBIN erbb2 interacting protein -0.0773922
IER3 immediate early response 3 -0.0765075
TM4SF1 transmembrane 4 L six family member 1 -0.0749405
FTL ferritin, light polypeptide -0.0721754
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0644053
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0636605
NRG1 neuregulin 1 -0.0589419
BIRC3 baculoviral IAP repeat containing 3 -0.0474123
USP34 ubiquitin specific peptidase 34 -0.0464937
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0458511
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0455352
ZNF207 zinc finger protein 207 -0.0450094
HDAC9 histone deacetylase 9 -0.0435777
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0432245
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0421354
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0418857
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0415686
KIF5B kinesin family member 5B -0.0411978
NIPBL Nipped-B homolog (Drosophila) -0.040631
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0397265
PFDN2 prefoldin subunit 2 -0.0397035
CLTC clathrin, heavy chain (Hc) -0.0390296
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0384496
PM20D1 peptidase M20 domain containing 1 -0.0378144
STC1 stanniocalcin 1 -0.0374113
GOLT1B golgi transport 1B -0.0365834
NCEH1 neutral cholesterol ester hydrolase 1 -0.0365459
SLC38A2 solute carrier family 38, member 2 -0.0361673
ASPH aspartate beta-hydroxylase -0.035468
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0353584
CSNK1A1 casein kinase 1, alpha 1 -0.03293
ITCH itchy E3 ubiquitin protein ligase -0.0310664
NTN4 netrin 4 -0.0298651
SENP6 SUMO1/sentrin specific peptidase 6 -0.0297483
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0290195
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0289737
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0288478
BICC1 BicC family RNA binding protein 1 -0.0285432
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0285126
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0280186
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0279734
RPS25 ribosomal protein S25 -0.0279254
KYNU kynureninase -0.0262856
GOLGA4 golgin A4 -0.0262404
UBXN4 UBX domain protein 4 -0.0261983
PUM2 pumilio RNA-binding family member 2 -0.0250537
RAB10 RAB10, member RAS oncogene family -0.0249668
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0249399
TASOR2 transcription activation suppressor family member 2 -0.0249345
UBASH3B ubiquitin associated and SH3 domain containing B -0.0248206
PAPOLA poly(A) polymerase alpha -0.0246985
MAPK8 mitogen-activated protein kinase 8 -0.0246901
FGG fibrinogen gamma chain -0.0245522
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0241714
SRPK1 SRSF protein kinase 1 -0.0240665
LRPPRC leucine-rich pentatricopeptide repeat containing -0.023859
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0237716
C15ORF48 chromosome 15 open reading frame 48 -0.0229309
ECT2 epithelial cell transforming 2 -0.0225283
CFLAR CASP8 and FADD-like apoptosis regulator -0.0224533
FGB fibrinogen beta chain -0.0219711
DSE dermatan sulfate epimerase -0.0218303
GPATCH2L G patch domain containing 2-like -0.0216374
NLK nemo-like kinase -0.0216208
DGKD diacylglycerol kinase, delta 130kDa -0.0214375
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0213133
CCL5 chemokine (C-C motif) ligand 5 -0.0213072
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.021044
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0207787
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0207276
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.020669
EIF5B eukaryotic translation initiation factor 5B -0.0205685
WAPL WAPL cohesin release factor -0.020545
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0205224
GPHN gephyrin -0.0204734
HBP1 HMG-box transcription factor 1 -0.020468
RPS27A ribosomal protein S27a -0.0201484
ARMH4 armadillo like helical domain containing 4 -0.0200145
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0198927
ATAD1 ATPase family, AAA domain containing 1 -0.0198871
TOR1AIP2 torsin A interacting protein 2 -0.0198548
GOLGB1 golgin B1 -0.0198236
ARF4 ADP-ribosylation factor 4 -0.0197618
TSC22D2 TSC22 domain family, member 2 -0.0197269
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0195201
MSRB3 methionine sulfoxide reductase B3 -0.0194814
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0194791
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0193866
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -0.0192669
SRP54 signal recognition particle 54kDa -0.0190411
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0190374
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0186081
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0185204