| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Irinotecan (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Irinotecan (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.114494 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.110078 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0899309 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0824835 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0799804 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0787407 |
| OGA | O-GlcNAcase | 0.0771917 |
| EZR | ezrin | 0.0754379 |
| IRS2 | insulin receptor substrate 2 | 0.0685894 |
| FAM13A | family with sequence similarity 13, member A | 0.0682766 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0674561 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0637736 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0631552 |
| PLEC | plectin | 0.062888 |
| SBF2 | SET binding factor 2 | 0.061364 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0608907 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.060556 |
| RPL23 | ribosomal protein L23 | 0.0589522 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0585039 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0576765 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0563707 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0561853 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0557914 |
| FLNB | filamin B, beta | 0.0546584 |
| USP3 | ubiquitin specific peptidase 3 | 0.0537138 |
| SMAD3 | SMAD family member 3 | 0.0533246 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0528717 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0521699 |
| FNIP1 | folliculin interacting protein 1 | 0.0518252 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0514863 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0511055 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0509084 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0508387 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0499641 |
| OXR1 | oxidation resistance 1 | 0.04801 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0476502 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0476429 |
| PFKP | phosphofructokinase, platelet | 0.0473075 |
| XPO1 | exportin 1 | 0.0471037 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0468139 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.046504 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0461172 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.045562 |
| VIM | vimentin | 0.0450605 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0449827 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0446744 |
| USP34 | ubiquitin specific peptidase 34 | 0.0440206 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0439458 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0438249 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0429299 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.042806 |
| MATR3 | matrin 3 | 0.0428034 |
| HPCAL1 | hippocalcin-like 1 | 0.042402 |
| ACTN4 | actinin, alpha 4 | 0.0421074 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0415935 |
| CENPF | centromere protein F, 350/400kDa | 0.041571 |
| NUP58 | nucleoporin 58 | 0.0415292 |
| TPR | translocated promoter region, nuclear basket protein | 0.0415251 |
| CTBP2 | C-terminal binding protein 2 | 0.0408668 |
| RNF145 | ring finger protein 145 | 0.040354 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0399636 |
| SERINC3 | serine incorporator 3 | 0.0398967 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.039771 |
| CD44 | CD44 molecule (Indian blood group) | 0.0391507 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.038946 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0386975 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0385213 |
| SNX9 | sorting nexin 9 | 0.0383655 |
| BRD2 | bromodomain containing 2 | 0.037773 |
| TPM3 | tropomyosin 3 | 0.0376593 |
| CD164 | CD164 molecule, sialomucin | 0.037591 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.037577 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0373238 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0373002 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0372589 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0372319 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0372023 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0367143 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0366612 |
| MED13L | mediator complex subunit 13-like | 0.0361616 |
| RUNX1 | runt-related transcription factor 1 | 0.0358836 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0358696 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0357578 |
| PTMA | prothymosin, alpha | 0.035605 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0353922 |
| TRIM56 | tripartite motif containing 56 | 0.0352045 |
| PHF3 | PHD finger protein 3 | 0.0349621 |
| TNPO1 | transportin 1 | 0.0349209 |
| ANKRD12 | ankyrin repeat domain 12 | 0.034878 |
| RBMX | RNA binding motif protein, X-linked | 0.0347605 |
| PTK2 | protein tyrosine kinase 2 | 0.0347142 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0343913 |
| TMSB4X | thymosin beta 4, X-linked | 0.0341181 |
| CLTC | clathrin, heavy chain (Hc) | 0.034056 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0340346 |
| SSH2 | slingshot protein phosphatase 2 | 0.0338334 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0337728 |
| ATXN1 | ataxin 1 | 0.0334167 |
| ATP11A | ATPase, class VI, type 11A | 0.0333178 |
| MYO10 | myosin X | 0.0331483 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.171973 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.161529 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.143178 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.118369 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.117652 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.100173 |
| RIGI | RNA sensor RIG-I | -0.0935448 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0845617 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0817433 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0816917 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.078488 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0766535 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0751011 |
| IGF2 | insulin-like growth factor 2 | -0.0714118 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0698455 |
| LMO7 | LIM domain 7 | -0.0690204 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0684316 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.066129 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0658974 |
| KIAA1217 | KIAA1217 | -0.0650571 |
| MYO1E | myosin IE | -0.0646288 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0636264 |
| SMYD3 | SET and MYND domain containing 3 | -0.0605295 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0592063 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0576322 |
| KIAA1671 | KIAA1671 | -0.0559547 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0546485 |
| ASPH | aspartate beta-hydroxylase | -0.0546368 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0540063 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0533776 |
| TPM4 | tropomyosin 4 | -0.0524573 |
| ANXA1 | annexin A1 | -0.0519104 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0516163 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0511525 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0500158 |
| PEG10 | paternally expressed 10 | -0.0497155 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.049029 |
| CANX | calnexin | -0.0489724 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0485341 |
| VRK2 | vaccinia related kinase 2 | -0.0476321 |
| NDRG1 | N-myc downstream regulated 1 | -0.0475296 |
| RUFY1 | RUN and FYVE domain containing 1 | -0.0469454 |
| UBN2 | ubinuclein 2 | -0.0466529 |
| FN1 | fibronectin 1 | -0.0465575 |
| DSG2 | desmoglein 2 | -0.0464468 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0452335 |
| PKP4 | plakophilin 4 | -0.044493 |
| RPS25 | ribosomal protein S25 | -0.0444507 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0444482 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.043854 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0433739 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0428315 |
| RIT2 | Ras-like without CAAX 2 | -0.0427206 |
| PARD3 | par-3 family cell polarity regulator | -0.0424552 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0423023 |
| CCDC186 | coiled-coil domain containing 186 | -0.0422379 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0420141 |
| SPAG9 | sperm associated antigen 9 | -0.0417403 |
| NEBL | nebulette | -0.0417196 |
| CREBBP | CREB binding protein | -0.0416852 |
| BPTF | bromodomain PHD finger transcription factor | -0.0414747 |
| TANK | TRAF family member-associated NFKB activator | -0.0410323 |
| RCOR1 | REST corepressor 1 | -0.0409609 |
| LDHA | lactate dehydrogenase A | -0.040921 |
| PRRC2C | proline-rich coiled-coil 2C | -0.04067 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.040604 |
| NUMB | numb homolog (Drosophila) | -0.0405081 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.040388 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | -0.0400488 |
| KYNU | kynureninase | -0.0396916 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0396581 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0394402 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0393464 |
| CPE | carboxypeptidase E | -0.039137 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0388938 |
| MUC16 | mucin 16, cell surface associated | -0.0383042 |
| PAPOLA | poly(A) polymerase alpha | -0.038222 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0378369 |
| CDK12 | cyclin-dependent kinase 12 | -0.0377002 |
| FBXO34 | F-box protein 34 | -0.037641 |
| RPL31 | ribosomal protein L31 | -0.0373752 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0371928 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0371639 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0369899 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0367048 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0366402 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0361176 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0357764 |
| PRSS23 | protease, serine, 23 | -0.0357407 |
| GOLGB1 | golgin B1 | -0.0357216 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0356621 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0353885 |
| MACC1 | metastasis associated in colon cancer 1 | -0.035386 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.0352784 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | -0.0351309 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0347294 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0346413 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0343767 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0343737 |
| MICA | MHC class I polypeptide-related sequence A | -0.0342696 |
